ArticleThe European physical journal. E, Soft matter2019
Pixantrone anticancer drug as a DNA ligand: Depicting the mechanism of action at single molecule level.
Article in The European physical journal. E, Soft matter, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed, 9 citations in OpenAlex.
- Interactions Involving Neutral Surfactants and Double-Stranded DNA: The Case of Polysorbate 80 (Tween 80).ACS omega · 2026Article
- Interactions of pixantrone with apurinic/apyrimidinic sites in DNA.microPublication biology · 2024Article
- Different Effects of Cisplatin and Transplatin on the Higher-Order Structure of DNA and Gene Expression.International journal of molecular sciences · 2019Article
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Authors and funding
4 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
In this work we use single molecule force spectroscopy performed with optical tweezers in order to characterize the complexes formed between the anticancer drug Pixantrone (PIX) and the DNA molecule, at two very different ionic strengths. Firstly, the changes of the mechanical properties of the DNA-PIX complexes were studied as a function of the drug concentration in the sample. Then, a quenched-disorder statistical model of ligand binding was used in order to determine the physicochemical (binding) parameters of the DNA-PIX interaction. In particular, we have found that the PIX molecular mechanism of action involves intercalation into the double helix, followed by a significant compaction of the DNA molecule due to partial neutralization of the phosphate backbone. Finally, this scenario of interaction was quantitatively compared to that found for the related drug Mitoxantrone (MTX), which binds to DNA with a considerably higher equilibrium binding constant and promotes a much stronger DNA compaction. The comparison performed between the two drugs can bring clues to the development of new (and more efficient) related compounds.
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