ArticleMetabolomics : Official journal of the Metabolomic Society2019
Predicting response to lisinopril in treating hypertension: a pilot study.
Article in Metabolomics : Official journal of the Metabolomic Society, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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Who cites it
4 citing papers in PubMed, 6 citations in OpenAlex.
- Untargeted metabolic analysis in serum samples reveals metabolic signature in children with congenital heart failure on enalapril therapy.Frontiers in pediatrics · 2025Article
- The contribution of the sphingosine 1-phosphate signaling pathway to chronic kidney diseases: recent findings and new perspectives.Pflugers Archiv : European journal of physiology · 2024Review
- Metabolomic Evaluation of N-Acetyl-p-Benzoquinone Imine Protein Adduct Formation with Therapeutic Acetaminophen Administration: Sex-based Physiologic Differences.Journal of medical toxicology : official journal of the American College of Medical Toxicology · 2022Article
- Metabolomic markers predictive of hepatic adaptation to therapeutic dosing of acetaminophen.Clinical toxicology (Philadelphia, Pa.) · 2022Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
introductionOnly ~ 50% of hypertensive patients will respond to treatment.
objectiveThis pilot study aims to identify clinical and metabolite markers that predict response to lisinopril.
methodsHypertensive patients (n = 45) received lisinopril (10 mg) at their baseline visit. Blood pressures were reevaluated one week later. Responders to lisinopril (n = 19) were defined by a 10% decline in systolic blood pressure. Plasma metabolites were evaluated with mass spectrometry.
resultsBMI (p = 0.009), GFR (p = 0.015) and 2-oxoglutarate were included in a logistic regression model to predict response to lisinopril.
conclusionsFurther validation cohorts are needed to confirm the predictive values of these clinical and metabolic markers.
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Registered trials
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