Evidence map›Paper›PMID 31583428›Full record

ArticleJournal of neurology2020

Clinical features distinguish cerebral amyloid angiopathy-associated convexity subarachnoid haemorrhage from suspected TIA.

Joel Elliot Dane Stanton, Arvind Chandratheva, Duncan Wilson, Isabel Charlotte Hostettler, Saiful Islam, David John Werring

Open access · hybridAbstract read
In one paragraph

Article in Journal of neurology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Convexity subarachnoid hemorrhage after mechanical thrombectomy.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
    Article
  4. Clinical Management of Cerebral Amyloid Angiopathy.Journal of clinical medicine · 2025
    Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. The frequency of central nervous system complications in the Cypriot cohort of ATTRV30M neuropathy transplanted patients.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2020
    Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Joel Elliot Dane StantonInstitute of Neurology Stroke Research Centre UCL, University College London, London, UK.
Arvind ChandrathevaInstitute of Neurology Stroke Research Centre UCL, University College London, London, UK.
Duncan WilsonStroke Research Centre, University College London, London, UK.
Isabel Charlotte HostettlerInstitute of Neurology Stroke Research Centre UCL, University College London, London, UK.
Saiful IslamDepartment of Statistical Science, UCL Institute of Neurology, University College London, London, UK.
David John WerringInstitute of Neurology Stroke Research Centre UCL, University College London, London, UK. d.werring@ucl.ac.uk.ORCID http://orcid.org/0000-0003-2074-1861
University College London · GBMRC Prion Unit · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo identity clinical features that distinguish between cerebral amyloid angiopathy (CAA)-associated convexity subarachnoid haemorrhage (cSAH) and suspected TIA.

methodsWe undertook a single-centre, retrospective case-control study. We identified cases [patients with cSAH presenting with transient focal neurological episodes (TFNE)] from radiological and clinical databases of patients assessed at the National Hospital for Neurology and Neurosurgery and UCLH Comprehensive Stroke Service. We identified age- and gender-matched controls at a 1:4 ratio from a database of consecutive suspected TIA clinic attendances at UCLH. We compared presenting symptoms and vascular risk factors between cases and controls.

resultsWe included 19 patients with cSAH-associated TFNE and 76 matched controls with suspected TIA. Migratory (spreading) symptoms (32% vs. 3%, OR 17.3; p = 0.001), sensory disturbance (47% vs. 14%, OR 5.3; p = 0.003,) and recurrent stereotyped events (47% vs. 19%, OR 3.7; p = 0.02,) occurred more frequently in patients with cSAH compared to controls. Hypercholesterolaemia was less common in patients with cSAH (16% vs 53%, OR 0.17; p = 0.008).

conclusionSimple clinical features could help distinguish cSAH-associated TFNE from suspected TIA, with relevance for investigation and management, including the use of antithrombotic drugs.

Indexed as

AgedAged, 80 and overCase-Control StudiesCerebral Amyloid AngiopathyDiagnosis, DifferentialFemaleHumansIschemic Attack, TransientMaleMiddle AgedRetrospective StudiesSubarachnoid HemorrhageCerebral amyloid angiopathyConvexial subarachnoid haemorrhageMimicNon-traumatic convexity subarachnoid haemorrhageTransient ischaemic attack

Identifiers

PMID31583428
PMCPMC6954887
OpenAlexW2978781132

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.