ArticleInternational journal of reproductive biomedicine2019
Expression of testicular phosphorylated proteins in types 1 and 2 diabetes mellitus in mice: An experimental study.
Article in International journal of reproductive biomedicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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5 citing papers in PubMed, 19 citations in OpenAlex.
- Histopathological examination of the protective effect of intense exercise in apoptotic germ cell damage due to diabetes.Acta cirurgica brasileira · 2023Article
- Article
- Knockdown of NRSF Alleviates Ischemic Brain Injury and Microvasculature Defects in Diabetic MCAO Mice.Frontiers in neurology · 2022Article
- Chronic stress increases the tyrosine phosphorylation in female reproductive organs: An experimental study.International journal of reproductive biomedicine · 2021Article
- Localization (and profiles) of tyrosinephosphorylated proteins in female reproductive organs of adult rats.Clinical and experimental reproductive medicine · 2020Article
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5 authors at 2 institutions in 1 country.
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Abstract
backgroundTypes 1 and 2 diabetes mellitus (DM) are known to be the cause of sub/infertility. However, the comparisons of potential markers in spermatogenesis and steroidogenesis in DM males have never been elucidated.
objectiveThis study aimed to examine the expressions of tyrosine-phosphorylated and steroidogenic acute regulatory (StAR) proteins in testis of DM mice. MATERIALS AND
methodsFifty-six male C57BL/6 mice were divided into four groups (n░=░14/ each): control of MLD-STZ (multiple low doses of streptozotocin), MLD-STZ, control of HFD-STZ (high-fat diet with STZ), and HFD-STZ. MLD-STZ mice (type 1 DM) were intraperitoneally (i.p.) injected with STZ at 40░mg/kg BW for five days. HFD-STZ mice (type 2 DM) received an HFD for 14 days and i.p.-induced by STZ at 85░mg/kg BW and fed with HFD. At the end of the experiment (days 36 and 72), the expressions of phosphorylated proteins and StAR were examined.
resultsTyrosine phosphorylated proteins were localized in late spermatids, luminal fluid, and Leydig cells. The intensities of phosphorylated 110, 85, 72, 60, and 55░kDas were lower in the 36 day-DM mice. Although such intensities were present in both groups, only 85░kDa in the MLD-STZ mice was higher in HFD mice at 72 days. StAR expressions in both groups were decreased than that of the controls.
conclusionDecreased expressions of StAR and tyrosine-phosphorylated proteins may be directly involved in low testosterone levels and impaired spermatogenesis. These findings support the notion that both DM types play a role in male infertility.
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