Evidence map›Paper›PMID 31583173›Full record

ArticleSurgical neurology international2019

Brain metastases from cervical cancer reduce longevity independent of overall tumor burden.

Ariel Takayanagi, T J Florence, Omid R Hariri, Abigail Armstrong, Pouria Yazdian, Andrew Sumida, Syed A Quadri, Joshua Cohen, Omid S Tehrani

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In one paragraph

Article in Surgical neurology international, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  3. Article
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  7. Observational
  8. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ariel TakayanagiDepartment of Neurosurgery, Riverside University Health Systems, Moreno Valley, USA.
T J FlorenceDepartment of Neurosurgery, Columbia University College of Physicians and Surgeons, New York, USA.
Omid R HaririDepartment of Neurosurgery, Stanford University School of Medicine, Stanford, USA.
Abigail ArmstrongDepartment of Obstetrics and Gynecology, University of California Los Angeles Medical Center, Santa Monica, USA.
Pouria YazdianDepartment of Medicine, Shahid Sadoughi University of Medical Sciences and Health Services, Yazd, Yazd Province, Iran.
Andrew SumidaDepartment of Internal Medicine, Center for Medical Education and Research, University of California San Francisco, Fresno, USA.
Syed A QuadriDepartment of Neurology, Harvard Medical School, Boston, MA, USA.
Joshua CohenDepartment of Neurological Surgery, Kaiser Permanente Orange County, Anaheim, USA.
Omid S TehraniDepartment of Oncology, Stanford Cancer Center, Stanford University School of Medicine, Stanford, CA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIsolated brain metastasis (IBM) from cervical cancer is a very rare encounter in neurosurgery. We sought to understand how patients with isolated brain metastases differ from those with metastases in the setting of widespread disease.

methodsA systematic review was completed using PubMed and the Cochrane Library. Patients with isolated brain metastases (IBM) and non-isolated brain metastases (NIBM, or brain metastases in the setting of disseminated disease), were compared. Two-sided statistical tests were used to determine significance. Survival function was carried out using the Kaplan-Meier method.

resultsA total of 89 patients, 25 with IBM and 64 with NIBM, were identified. The time interval between initial diagnosis of cervical cancer and diagnosis of brain lesion was significantly shorter in the IBM group (median 7.5 vs. 20.05 months, and IBM vs. NIBM, respectively;

conclusionTaken together, our data suggest that for cervical cancer patients with brain metastasis intracranial metastasis itself (and not overall tumor burden) represent a sentinel event in limiting longevity. While the present study is underpowered to compare treatment options directly, further work should be focused on determining the optimal treatment for these patients.

Indexed as

BrainCancerCervicalCervixIsolatedMetastasesNon-isolatedSurvivalUterineUterus

Identifiers

PMID31583173
PMCPMC6763668

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.