ArticleCase reports in oncological medicine2019
High Cervical Intrathecal Targeted Drug Delivery: A Case Report of Refractory Oropharyngeal Cancer Pain.
Article in Case reports in oncological medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Technical guideline for intra-prepontine cisternal drug delivery via spinal puncture through subarachnoid catheterization.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2024Guideline
- [Effect of morphine pump in prepontine cistern via lumbar approach for intractable head and neck cancer pain].Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2025Article
- Treatment of severe pain in a patient with a cervical spinal cord injury at C5-7 level using an intrathecal targeted drug delivery system - A case report.Anesthesia and pain medicine · 2025Article
- Short-term cervical spinal cord stimulation for central post-stroke pain: a case report and literature review.Annals of medicine and surgery (2012) · 2024Article
- Concept for intrathecal delivery of brain recording and stimulation device.Frontiers in medical technology · 2024Article
- Interpeduncular cistern intrathecal targeted drug delivery for intractable postherpetic neuralgia: A case report.World journal of clinical cases · 2023Article
- Prepontine cisternal routine for intrathecal targeted drug delivery in craniofacial cancer pain treatment: technical note.Drug delivery · 2022Article
- Machine learning for infection risk prediction in postoperative patients with non-mechanical ventilation and intravenous neurotargeted drugs.Frontiers in neurology · 2022Article
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionSome patients with head and neck cancers have pain refractory to aggressive multimodal therapies. Herein, we report the use of an intrathecal targeted drug delivery (TDD) system catheter tip placed at C1 for the treatment of recalcitrant oropharyngeal cancer pain. CASE REPORT: A patient with recurrent metastatic squamous cell tongue cancer reported severe pain not controlled despite high-dose opioids and nonopioid adjuvants. It was elected to proceed with an intrathecal TDD system with the catheter tip placed at the C1 level. After pump placement, we were able to decrease her daily oral morphine equivalents (OME) from nearly 1000 mg to 300 mg over the course of two months while titrating her TDD from 0.3 mg/day to 0.7 mg/day of intrathecal hydromorphone. Unfortunately, her improvement was limited secondary to aggressive cancer-directed treatments likely contributing to device infection and explant.
conclusionsIn this patient, high cervical placement of an intrathecal TDD catheter was associated with a decrease in OME. While used in clinical practice on occasion, the use of high cervical TDD placement such as this implantable C1 intrathecal TDD system for cancer-associated pain is underreported in the literature. Further studies on this intervention within this challenging population are warranted.
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