ArticleNPJ systems biology and applications2019
Osmolyte homeostasis controls single-cell growth rate and maximum cell size of
Article in NPJ systems biology and applications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 24 citations in OpenAlex.
- Article
- The "weaken-fill-repair" model for cell budding: Linking cell wall biosynthesis with mechanics.iScience · 2024Article
- Study of impacts of two types of cellular aging on the yeast bud morphogenesis.PLoS computational biology · 2024Article
- Data integration strategies for whole-cell modeling.FEMS yeast research · 2024Review
- Phenotypic consequences of logarithmic signaling in MAPK stress response.bioRxiv : the preprint server for biology · 2023Article
- Quantifying turgor pressure in budding and fission yeasts based upon osmotic properties.Molecular biology of the cell · 2023Article
- Quantifying turgor pressure in budding and fission yeasts based upon osmotic properties.bioRxiv : the preprint server for biology · 2023Article
- Yeast osmoregulation - glycerol still in pole position.FEMS yeast research · 2022Review
- Control of nuclear size by osmotic forces ineLife · 2022Article
- Potassium and Sodium Salt Stress Characterization in the Yeasts Saccharomyces cerevisiae, Kluyveromyces marxianus, andApplied and environmental microbiology · 2021Article
- The importance of water and hydraulic pressure in cell dynamics.Journal of cell science · 2020Review
- Role of combined cell membrane and wall mechanical properties regulated by polarity signals in cell budding.Physical biology · 2020Article
- The environmental stress response causes ribosome loss in aneuploid yeast cells.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cell growth is well described at the population level, but precisely how nutrient and water uptake and cell wall expansion drive the growth of single cells is poorly understood. Supported by measurements of single-cell growth trajectories and cell wall elasticity, we present a single-cell growth model for yeast. The model links the thermodynamic quantities, such as turgor pressure, osmolarity, cell wall elasto-plasticity, and cell size, applying concepts from rheology and thin shell theory. It reproduces cell size dynamics during single-cell growth, budding, and hyper-osmotic or hypo-osmotic stress. We find that single-cell growth rate and final size are primarily governed by osmolyte uptake and consumption, while bud expansion requires additionally different cell wall extensibilities between mother and bud. Based on first principles the model provides a more accurate description of size dynamics than previous attempts and its analytical simplification allows for easy combination with models for other cell processes.
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Registered trials
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