Evidence map›Paper›PMID 31583115›Full record

ArticleNPJ systems biology and applications2019

Utilizing genome-scale models to optimize nutrient supply for sustained algal growth and lipid productivity.

Chien-Ting Li, Jacob Yelsky, Yiqun Chen, Cristal Zuñiga, Richard Eng, Liqun Jiang, Alison Shapiro, Kai-Wen Huang, Karsten Zengler, Michael J Betenbaugh

Open access · goldAbstract read
In one paragraph

Article in NPJ systems biology and applications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.0field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 36 citations in OpenAlex.

  1. Review
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  8. Metabolic network reconstruction ofFrontiers in microbiology · 2023
    Review
  9. Review
  10. Article
  11. Article
  12. Review
  13. Maximizing Energy Content and COFrontiers in bioengineering and biotechnology · 2021
    Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Chien-Ting Li1Department of Chemical and Biomolecular Engineering, Johns Hopkins University, 3400 North Charles Street, Baltimore, MD 21218 USA.
Jacob Yelsky1Department of Chemical and Biomolecular Engineering, Johns Hopkins University, 3400 North Charles Street, Baltimore, MD 21218 USA.ORCID 0000-0001-9342-6390
Yiqun Chen1Department of Chemical and Biomolecular Engineering, Johns Hopkins University, 3400 North Charles Street, Baltimore, MD 21218 USA.ORCID 0000-0003-3074-9605
Cristal Zuñiga2Department of Pediatrics, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0760 USA.ORCID 0000-0002-0135-7429
Richard Eng1Department of Chemical and Biomolecular Engineering, Johns Hopkins University, 3400 North Charles Street, Baltimore, MD 21218 USA.
Liqun Jiang1Department of Chemical and Biomolecular Engineering, Johns Hopkins University, 3400 North Charles Street, Baltimore, MD 21218 USA.
Alison Shapiro1Department of Chemical and Biomolecular Engineering, Johns Hopkins University, 3400 North Charles Street, Baltimore, MD 21218 USA.ORCID 0000-0002-4553-7421
Kai-Wen Huang1Department of Chemical and Biomolecular Engineering, Johns Hopkins University, 3400 North Charles Street, Baltimore, MD 21218 USA.ORCID 0000-0002-9176-9434
Karsten Zengler2Department of Pediatrics, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0760 USA.
Michael J Betenbaugh1Department of Chemical and Biomolecular Engineering, Johns Hopkins University, 3400 North Charles Street, Baltimore, MD 21218 USA.
Johns Hopkins University · USUniversity of California San Diego · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nutrient availability is critical for growth of algae and other microbes used for generating valuable biochemical products. Determining the optimal levels of nutrient supplies to cultures can eliminate feeding of excess nutrients, lowering production costs and reducing nutrient pollution into the environment. With the advent of omics and bioinformatics methods, it is now possible to construct genome-scale models that accurately describe the metabolism of microorganisms. In this study, a genome-scale model of the green alga

Indexed as

AlgorithmsAutotrophic ProcessesBatch Cell Culture TechniquesBiomassBiotechnologyChlorella vulgarisCyanobacteriaFatty AcidsGlucoseLipidsMicroalgaeNitrogenNutrientsSystems BiologyFatty AcidsGlucoseLipidsNitrogenNutrientsBiotechnologyComputer modellingSystems biology

Identifiers

PMID31583115
PMCPMC6760154
OpenAlexW2976601076

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.