ArticleNutrition research and practice2019
Anti-diabetic effects of blue honeyberry on high-fed-diet-induced type II diabetic mouse.
Article in Nutrition research and practice, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 25 citations in OpenAlex.
- Impact of the gut microbiome on health impacts of Haskap berries: study protocol for a randomized control trial.Trials · 2026Article
- Lipid droplet dynamics in type 2 diabetes and its complications: pathophysiological insights and therapeutic options.Lipids in health and disease · 2025Review
- Bioactive Compounds and In Vitro Health-Promoting Activity of the Fruit Skin and Flesh of Different Haskap Berry (International journal of molecular sciences · 2025Article
- A Systematic Review of Cardio-Metabolic Properties ofAntioxidants (Basel, Switzerland) · 2024Review
- Decoding the enhanced antioxidant activities of the combined small berry pomaces by widely targeted metabolomics analysis.Heliyon · 2023Article
- The Chemical Profile, Antioxidant, and Anti-Lipid Droplet Activity of Fluid Extracts from Romanian Cultivars of Haskap Berries, Bitter Cherries, and Red Grape Pomace for the Management of Liver Steatosis.International journal of molecular sciences · 2023Article
- Haskap Berry Leaves (Nutrients · 2022Article
- Honeysuckle Berry (Molecules (Basel, Switzerland) · 2022Article
- Phenolic Compounds, Vitamins C and E and Antioxidant Activity of Edible Honeysuckle Berries (Antioxidants (Basel, Switzerland) · 2022Article
- Recent Studies on Berry Bioactives and Their Health-Promoting Roles.Molecules (Basel, Switzerland) · 2021Review
- Antioxidant Effect ofAntioxidants (Basel, Switzerland) · 2021Article
- Health Properties and Composition of Honeysuckle BerryMolecules (Basel, Switzerland) · 2020Review
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Authors and funding
5 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
objectiveThe blue honeysuckle berry ( MATERIALS/
methodsThe hypoglycemic effects were based on the observed changes in insulin, blood glucose, and glycated hemoglobin (HbA1c). Furthermore, the changes in the weight of the pancreas, including its histopathology and immunohistochemical investigation were also performed. Moreover, the nephroprotective effects were analyzed by observing the changes in kidney weight, its histopathology, blood urea nitrogen (BUN), and serum creatinine levels.
resultsThe results showed that the high-fat diet (HFD)-induced control mice showed a noticeable increase in blood glucose, insulin, HbA1c, BUN, and creatinine levels. Furthermore, growth was observed in lipid droplet deposition related to the degenerative lesions in the vacuolated renal tubules with the evident enlargement and hyperplasia of the pancreatic islets. In addition, in the endocrine pancreas, there was an increase in the insulin-and glucagon-producing cells, as well as in the insulin/glucagon cell ratios. On the other hand, compared to the HFD-treated mice group, all these diabetic and related complications were ameliorated significantly in a dose-dependent manner after 84 days of the continuous oral administration of BHBe at 400, 200 and 100 mg/kg, and a dramatic resettlement in the hepatic glucose-regulating enzyme activities was observed.
conclusionsBy assessing the key parameters for T2DM, the present study showed that the BHBe could act as a potential herbal agent to cure diabetes (type II) and associated ailments in HFD-induced mice.
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