ArticleNature2019
Dynamics and genomic landscape of CD8
Abstract read
In one paragraph
Article in Nature, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 137 papers.
0numbers the graph read from it
0cells of the map it votes in
137citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
137 citing papers in PubMed.
- Safety, pharmacokinetics, and pharmacodynamics of the antisense oligonucleotide RO7239958 in healthy volunteers and adults with chronic hepatitis B infection.Antimicrobial agents and chemotherapy · 2025Trial
- Selective decrease of donor-reactive TScience translational medicine · 2022Trial
- ANKRD11 deficiency reprograms CD8Nature immunology · 2026Article
- Review
- Liver Macrophages in the Pathogenesis of Viral Hepatitis.Current issues in molecular biology · 2026Review
- mRNA vaccines engage unconventional pathways in CD8Nature · 2026Article
- Kupffer cell calibration of T cell responses via VSIG4-CD5 interaction promotes tumor evasion.Nature immunology · 2026Article
- Functional cure for chronic hepatitis B: A state of immune control over cccDNA persistence.Infectious diseases & immunity · 2026Review
- T-Cell Profiles in HBV Functional Cure and People Living With HIV: Known Knowns, Known Unknowns, and Unknown Unknowns.Current HIV/AIDS reports · 2026Review
- Immune Exhaustion in Chronic Infection and Cancer: Signaling Pathways and Therapeutic Interventions.MedComm · 2026Review
- The immunoecology of occult hepatitis B virus infection: genetic remodeling and the immune-mediated microcosm.Frontiers in immunology · 2026Review
- Aging-induced hepatocyte CD44 drives IL6/STAT3 signaling and associates with impaired neighboring T cell function.bioRxiv : the preprint server for biology · 2025Article
- The role of PD‑1/PD‑L1 axis in liver diseases.Clinical and experimental medicine · 2025Review
- Tissue-resident memory CD8Nature reviews. Gastroenterology & hepatology · 2025Review
- HBV Suppression by Nucleos(t)ide Analogues Reduces PD-1 Expression on Liver-Resident T Cells.Liver international : official journal of the International Association for the Study of the Liver · 2025Article
- Inflammation and immunity in liver homeostasis and disease: a nexus of hepatocytes, nonparenchymal cells and immune cells.Cellular & molecular immunology · 2025Review
- Viral-Directed Augmentation of Kupffer Cell Cross-Presentation Provokes Antitumor Immunity Against Liver Metastasis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- MVA-HBVac-A novel vaccine vector that allows pan-genotypic targeting of hepatitis B virus by therapeutic vaccination.Molecular therapy. Nucleic acids · 2025Article
- CD4Nature immunology · 2025Article
- A liver-centric help circuit revives CD8Nature immunology · 2025Article
77 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
28 authors.
Alexandre P Bénéchet *Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Giorgia De Simone *Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Pietro Di LuciaDivision of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Francesco CilentiVita-Salute San Raffaele University, Milan, Italy.
Giulia BarbieraSan Raffaele Telethon Institute for Gene Therapy (SR-TIGET), IRCCS San Raffaele Scientific Institute, Milan, Italy.
Nina Le BertEmerging Infectious Disease Program, Duke-NUS Medical School, Singapore, Singapore.
Valeria FumagalliDivision of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Eleonora LusitoSan Raffaele Telethon Institute for Gene Therapy (SR-TIGET), IRCCS San Raffaele Scientific Institute, Milan, Italy.
Federica MoalliDivision of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Valentina BianchessiVita-Salute San Raffaele University, Milan, Italy.
Francesco AndreataDivision of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Paola ZordanDivision of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Elisa BonoDivision of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Leonardo GiustiniDivision of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Weldy V BonillaDivision of Experimental Virology, Department of Biomedicine, University of Basel, Basel, Switzerland.
Camille BleriotSingapore Immunology Network, Singapore Agency for Science, Technology & Research (A∗STAR), Singapore, Singapore.
Kamini KunasegaranEmerging Infectious Disease Program, Duke-NUS Medical School, Singapore, Singapore.
Gloria Gonzalez-AseguinolazaGene Therapy and Gene Regulation Program, Centre for Applied Medical Research, Pamplona, Spain.
Daniel D PinschewerDivision of Experimental Virology, Department of Biomedicine, University of Basel, Basel, Switzerland.
Patrick T F KennedyBarts Liver Centre, Barts and The London School of Medicine & Dentistry, Queen Mary University of London, London, UK.
Luigi NaldiniVita-Salute San Raffaele University, Milan, Italy.
Mirela KukaDivision of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Florent GinhouxSingapore Immunology Network, Singapore Agency for Science, Technology & Research (A∗STAR), Singapore, Singapore.
Alessio CantoreVita-Salute San Raffaele University, Milan, Italy.
Antonio BertolettiEmerging Infectious Disease Program, Duke-NUS Medical School, Singapore, Singapore.
Renato OstuniVita-Salute San Raffaele University, Milan, Italy.
Luca G GuidottiDivision of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Matteo IannaconeDivision of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy. iannacone.matteo@hsr.it.
Funding
European Research Council 725038
Abstract
The responses of CD8
Indexed as
AnimalsB7-H1 AntigenCD8-Positive T-LymphocytesCell DifferentiationChromatinCross-PrimingFemaleHepatitis BHepatitis B virusHepatocytesHumansImmune ToleranceInterleukin-2Kupffer CellsLymphocyte ActivationMaleB7-H1 AntigenChromatinInterleukin-2
Identifiers
What OpenQuestion holds
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LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.