Evidence map›Paper›PMID 31582804›Full record

ArticleCell death and differentiation2020

Cumulative inactivation of Nell-1 in Wnt1 expressing cell lineages results in craniofacial skeletal hypoplasia and postnatal hydrocephalus.

Xiaoyan Chen, Huiming Wang, Mengliu Yu, Jong Kil Kim, Huichuan Qi, Pin Ha, Wenlu Jiang, Eric Chen, Xiangyou Luo, Ryan Brent Needle and 7 more

Erratum issuedOpen access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell death and differentiation, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
0.4field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Article
  3. NELL-1: role and mechanisms in disease pathogenesis and development.Frontiers in cell and developmental biology · 2026
    Review
  4. Review
  5. Article
  6. Article
  7. Role of NEL‑like molecule‑1 in osteogenesis/chondrogenesis (Review).International journal of molecular medicine · 2025
    Review
  8. METTL3-dependent mCell death & disease · 2024
    Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Review
  14. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors at 3 institutions in 2 countries.

Xiaoyan Chen *Department of Orthodontics, Affiliated Hospital of Stomatology, Medical College, Zhejiang University, Hangzhou, Zhejiang, PR China.
Huiming Wang *Department of Oral Implantology, Affiliated Hospital of Stomatology, Medical College, Zhejiang University, Hangzhou, Zhejiang, PR China.
Mengliu Yu *Department of Oral Implantology, Affiliated Hospital of Stomatology, Medical College, Zhejiang University, Hangzhou, Zhejiang, PR China.
Jong Kil KimDivision of Growth and Development, Section of Orthodontics, School of Dentistry, University of California, Los Angeles, CA, USA.
Huichuan QiDivision of Growth and Development, Section of Orthodontics, School of Dentistry, University of California, Los Angeles, CA, USA.
Pin HaDivision of Growth and Development, Section of Orthodontics, School of Dentistry, University of California, Los Angeles, CA, USA.
Wenlu JiangDivision of Growth and Development, Section of Orthodontics, School of Dentistry, University of California, Los Angeles, CA, USA.
Eric ChenDivision of Growth and Development, Section of Orthodontics, School of Dentistry, University of California, Los Angeles, CA, USA.
Xiangyou LuoDivision of Growth and Development, Section of Orthodontics, School of Dentistry, University of California, Los Angeles, CA, USA.
Ryan Brent NeedleDivision of Growth and Development, Section of Orthodontics, School of Dentistry, University of California, Los Angeles, CA, USA.
Lloyd BaikDivision of Growth and Development, Section of Orthodontics, School of Dentistry, University of California, Los Angeles, CA, USA.
Cathryn YangDivision of Growth and Development, Section of Orthodontics, School of Dentistry, University of California, Los Angeles, CA, USA.
Jiejun ShiDepartment of Orthodontics, Affiliated Hospital of Stomatology, Medical College, Zhejiang University, Hangzhou, Zhejiang, PR China.
Jin Hee KwakDivision of Growth and Development, Section of Orthodontics, School of Dentistry, University of California, Los Angeles, CA, USA.
Kang Ting *Division of Growth and Development, Section of Orthodontics, School of Dentistry, University of California, Los Angeles, CA, USA.
Xinli Zhang *Division of Growth and Development, Section of Orthodontics, School of Dentistry, University of California, Los Angeles, CA, USA. xzhang@dentistry.ucla.edu.
Chia Soo *Department of Orthopaedic Surgery and the Orthopaedic Hospital Research Center, UCLA and Orthopaedic Hospital, University of California, Los Angeles, CA, USA.
University of California, Los Angeles · USZhejiang University · CNJilin University · CN

Funding

UCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1M
UCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0M
NELL-1's functional role in cartilage regenerationR01AR068835 · NIAMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI EASLEY, JEREMIAH, SOO, CHIA · 2015 to 2019
$2.2M
NELL-1 Systemic Therapy for OsteoporosisR01AR066782 · NIAMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI EASLEY, JEREMIAH, TING, KANG · 2014 to 2018
$2.0M
Wnt and PPARy Signaling in Nell-1 and BMP2 Mediated Bone RegenerationR01AR061399 · NIAMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SOO, CHIA · 2012 to 2016
$1.7M
Novel systemic PEGylated NELL-1 therapy for craniofacial osteoporosisK08DE026805 · NIDCR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI KWAK, JIN HEE · 2017 to 2020
$633k
NCATS NIH HHS UL1 TR000124NIAMS NIH HHS R01 AR061399NIAMS NIH HHS R01 AR066782NIAMS NIH HHS R01 AR068835NIDCR NIH HHS K08 DE026805
6 · The paper itself

Abstract

Upregulation of Nell-1 has been associated with craniosynostosis (CS) in humans, and validated in a mouse transgenic Nell-1 overexpression model. Global Nell-1 inactivation in mice by N-ethyl-N-nitrosourea (ENU) mutagenesis results in neonatal lethality with skeletal abnormalities including cleidocranial dysplasia (CCD)-like calvarial bone defects. This study further defines the role of Nell-1 in craniofacial skeletogenesis by investigating specific inactivation of Nell-1 in Wnt1 expressing cell lineages due to the importance of cranial neural crest cells (CNCCs) in craniofacial tissue development. Nell-1

Indexed as

Cell LineageAnimalsAnimals, NewbornCalcium-Binding ProteinsCell DifferentiationCraniofacial AbnormalitiesDown-RegulationFemaleHydrocephalusMice, Inbred C57BLMice, KnockoutMutationNeural CrestOsteochondrodysplasiasOsteogenesisPenetranceCalcium-Binding ProteinsNell1 protein, mouseWnt1 Protein

Identifiers

PMID31582804
PMCPMC7206096
OpenAlexW2979135151

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.