ArticleScientific reports2019
Topography and behavioral relevance of the global signal in the human brain.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 78 papers, 1 of them a synthesis that pooled it.
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Who cites it
78 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A technical review of canonical correlation analysis for neuroscience applications.Human brain mapping · 2020Pooled it
- Comprehensive profiling of brain dynamics during anesthesia across phylogeny.Nature neuroscience · 2026Article
- Global brain activity links subcortical degeneration to cortical tau progressively across Braak regions over early Alzheimer's disease stages.Nature communications · 2026Article
- Global Signal Removal (GSR) as graph spatial filtering.bioRxiv : the preprint server for biology · 2026Article
- Sleep deprivation exhibits an age-dependent effect on infraslow global brain activity.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Global cortical arousal effects in fMRI reveal brain markers of state and trait anxiety.Cerebral cortex (New York, N.Y. : 1991) · 2026Article
- Global brain activity links subcortical degeneration to cortical tau progressively across Braak regions over early Alzheimer's disease stages.bioRxiv : the preprint server for biology · 2026Article
- Early menopause is associated with reduced global brain activity.bioRxiv : the preprint server for biology · 2025Article
- Altered dynamic functional connectivity and reduced higher order information interaction in Parkinson's patients with hyposmia.NPJ systems biology and applications · 2025Article
- Patterns of pathological tau deposition reflect the dynamics of cortical brain activity.Cell reports · 2025Article
- The Transdiagnostic Connectome Project: an open dataset for studying brain-behavior relationships in psychiatry.Scientific data · 2025Article
- The functional overlap between respiration and global signal and its behavioral relevance.Communications biology · 2025Article
- Review
- General anaesthesia decreases the uniqueness of brain functional connectivity across individuals and species.Nature human behaviour · 2025Article
- Reproducible Effects of Sex and Acquisition Order on Multiple Global Signal Metrics: Implications for Functional Connectivity Studies of Phenotypic Individual Differences Using fMRI.Brain and behavior · 2025Article
- The Impact of Atlas Parcellation on Functional Connectivity Analysis Across Six Psychiatric Disorders.Human brain mapping · 2025Article
- The lifelong nonlinear development of spatial variability of brain signals.Communications biology · 2025Article
- Global signal regression reduces connectivity patterns related to physiological signals and does not alter EEG-derived connectivity.Frontiers in neuroimaging · 2025Article
- The brain's first "traffic map" through Unified Structural and Functional Connectivity (USFC) modeling.Communications biology · 2024Article
- Human brain state dynamics are highly reproducible and associated with neural and behavioral features.PLoS biology · 2024Article
18 more citing papers are in PubMed but not listed here.
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Authors and funding
7 authors.
Funding
Abstract
The global signal in resting-state functional MRI data is considered to be dominated by physiological noise and artifacts, yet a growing literature suggests that it also carries information about widespread neural activity. The biological relevance of the global signal remains poorly understood. Applying principal component analysis to a large neuroimaging dataset, we found that individual variation in global signal topography recapitulates well-established patterns of large-scale functional brain networks. Using canonical correlation analysis, we delineated relationships between individual differences in global signal topography and a battery of phenotypes. The first canonical variate of the global signal, resembling the frontoparietal control network, was significantly related to an axis of positive and negative life outcomes and psychological function. These results suggest that the global signal contains a rich source of information related to trait-level cognition and behavior. This work has significant implications for the contentious debate over artifact removal practices in neuroimaging.
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