ArticleScientific reports2019
Type I toxin-dependent generation of superoxide affects the persister life cycle of Escherichia coli.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 40 citations in OpenAlex.
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- Effect of Metal Bionanohybrids on Pre-formed Marine Biofilms.ACS applied bio materials · 2025Article
- Beyond Resistance: Tolerance and Resilience of Bacteria to Photodynamic and Oxidative Stress.International journal of molecular sciences · 2025Review
- A rational approach to discovering new persister control agents.Antimicrobial agents and chemotherapy · 2025Article
- Dogs fed raw meat-based diets are vectors of drug-resistant Salmonella infection in humans.Communications medicine · 2025Article
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- Functional diversity and molecular interactions of small membrane proteins in bacteria.microLife · 2025Review
- Type I toxin-antitoxin systems in bacteria: from regulation to biological functions.EcoSal Plus · 2024Review
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- Relevance of charged and polar amino acids for functionality of membrane toxin TisB.Scientific reports · 2024Article
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- TisB protein is the single molecular determinant underlying multiple downstream effects of ofloxacin inScience advances · 2024Article
- Heterogeneous Phenotypic Responses of Antibiotic-ResistantAntibiotics (Basel, Switzerland) · 2023Article
- The Functionality of IbpA fromInternational journal of molecular sciences · 2023Article
- Targeting Superoxide dismutase confers enhanced Reactive Oxygen Species mediated eradication of Polymyxin B inducedAntimicrobial agents and chemotherapy · 2023Article
- Mechanism of action ofFrontiers in microbiology · 2023Article
- An Easy-to-Use Plasmid Toolset for Efficient Generation and Benchmarking of Synthetic Small RNAs in Bacteria.ACS synthetic biology · 2022Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Induction of growth stasis by bacterial toxins from chromosomal toxin-antitoxin systems is suspected to favor formation of multidrug-tolerant cells, named persisters. Recurrent infections are often attributed to resuscitation and regrowth of persisters upon termination of antibiotic therapy. Several lines of evidence point to oxidative stress as a crucial factor during the persister life cycle. Here, we demonstrate that the membrane-depolarizing type I toxins TisB, DinQ, and HokB have the potential to provoke reactive oxygen species formation in Escherichia coli. More detailed work with TisB revealed that mainly superoxide is formed, leading to activation of the SoxRS regulon. Deletion of the genes encoding the cytoplasmic superoxide dismutases SodA and SodB caused both a decline in TisB-dependent persisters and a delay in persister recovery upon termination of antibiotic treatment. We hypothesize that expression of depolarizing toxins during the persister formation process inflicts an oxidative challenge. The ability to counteract oxidative stress might determine whether cells will survive and how much time they need to recover from dormancy.
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