Evidence map›Paper›PMID 31582560›Full record

ArticleThe Journal of biological chemistry2019

Imaging of morphological and biochemical hallmarks of apoptosis with optimized optogenetic tools.

Walton C Godwin, George F Hoffmann, Taylor J Gray, Robert M Hughes

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.0field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 29 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Optogenetic engineering for precision cancer immunotherapy.Trends in pharmacological sciences · 2025
    Review
  7. Article
  8. Review
  9. Article
  10. Alternating Cellular Functions by Optogenetic Control of Organelles.Methods in molecular biology (Clifton, N.J.) · 2025
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Review
  17. Optogenetic Control of Cardiac Autonomic Neurons in Transgenic Mice.Methods in molecular biology (Clifton, N.J.) · 2021
    Article
  18. Engineering Photosensory Modules of Non-Opsin-Based Optogenetic Actuators.International journal of molecular sciences · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Walton C GodwinDepartment of Chemistry, East Carolina University, Greenville, North Carolina 27858.
George F HoffmannDepartment of Chemistry, East Carolina University, Greenville, North Carolina 27858.
Taylor J GrayDepartment of Biology, East Carolina University, Greenville, North Carolina 27858.
Robert M HughesDepartment of Chemistry, East Carolina University, Greenville, North Carolina 27858 hughesr16@ecu.edu.ORCID 0000-0002-4465-4212
East Carolina University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Creation of optogenetic switches for specific activation of cell death pathways can provide insights into apoptosis and could also form a basis for noninvasive, next-generation therapeutic strategies. Previous work has demonstrated that cryptochrome 2 (Cry2)/cryptochrome-interacting β helix-loop-helix (CIB), a blue light-activated protein-protein dimerization module from the plant

Indexed as

ApoptosisOptogeneticsActinsActive Transport, Cell NucleusBiomarkersCaspase 3Caspase 7Cell NucleusHEK293 CellsHumansProteolysisActinsBiomarkersCaspase 3Caspase 7actinapoptosisBaxBCL2-associated X apoptosis regulator (BAX)cryptochromecytoskeletal dynamicscytoskeletoneffector moleculemitochondrial apoptosismitochondrial outer membrane permeabilization (MOMP)OptoBAX 2.0 systemoptogenetics

Identifiers

PMID31582560
PMCPMC6851291
OpenAlexW2977836534

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.