Evidence map›Paper›PMID 31582559›Full record

ArticleDisease models & mechanisms2019

Targeted knockout of GABA-A receptor gamma 2 subunit provokes transient light-induced reflex seizures in zebrafish larvae.

Meijiang Liao, Uday Kundap, Richard E Rosch, Dominic R W Burrows, Martin P Meyer, Bouchra Ouled Amar Bencheikh, Patrick Cossette, Éric Samarut

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Disease models & mechanisms, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 43 citations in OpenAlex.

  1. Article
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  5. GABAmicroPublication biology · 2025
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  10. Microscale Neuronal Activity Collectively Drives Chaotic and Inflexible Dynamics at the Macroscale in Seizures.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023
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  11. Review
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  20. TheAnnals of translational medicine · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 3 countries.

Meijiang LiaoResearch Center of the University of Montreal Hospital Center (CRCHUM), Department of Neurosciences, Université de Montréal, Montréal, QC H2X 0A9, Canada.
Uday KundapResearch Center of the University of Montreal Hospital Center (CRCHUM), Department of Neurosciences, Université de Montréal, Montréal, QC H2X 0A9, Canada.ORCID 0000-0003-4791-4646
Richard E RoschDepartment for Developmental Neurobiology, MRC Centre for Neurodevelopmental Disorders, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London SE1 1UL, UK.ORCID 0000-0002-0316-5818
Dominic R W BurrowsDepartment for Developmental Neurobiology, MRC Centre for Neurodevelopmental Disorders, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London SE1 1UL, UK.
Martin P MeyerDepartment for Developmental Neurobiology, MRC Centre for Neurodevelopmental Disorders, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London SE1 1UL, UK.
Bouchra Ouled Amar BencheikhMontreal Neurological Institute and Hospital, McGill University, Montréal, QC H3A 2B4, Canada.ORCID 0000-0002-3659-941X
Patrick CossetteResearch Center of the University of Montreal Hospital Center (CRCHUM), Department of Neurosciences, Université de Montréal, Montréal, QC H2X 0A9, Canada.
Éric SamarutResearch Center of the University of Montreal Hospital Center (CRCHUM), Department of Neurosciences, Université de Montréal, Montréal, QC H2X 0A9, Canada eric.samarut@umontreal.ca.ORCID 0000-0001-7818-2009
Université de Montréal · CAKing's College London · GBMontreal Neurological Institute and Hospital · CA

Funding

Wellcome TrustWellcome Trust 209164/Z/17/Z
6 · The paper itself

Abstract

Epilepsy is a common primary neurological disorder characterized by the chronic tendency of a patient to experience epileptic seizures, which are abnormal body movements or cognitive states that result from excessive, hypersynchronous brain activity. Epilepsy has been found to have numerous etiologies and, although about two-thirds of epilepsies were classically considered idiopathic, the majority of those are now believed to be of genetic origin. Mutations in genes involved in gamma-aminobutyric acid (GABA)-mediated inhibitory neurotransmission have been associated with a broad range of epilepsy syndromes. Mutations in the GABA-A receptor gamma 2 subunit gene (

Indexed as

Disease Models, AnimalAnimalsGene Knockout TechniquesLarvaLightProtein SubunitsReceptors, GABA-AReflexSeizuresTranscriptomeValproic AcidZebrafishProtein SubunitsReceptors, GABA-AValproic AcidEpilepsyGABAGABA receptorNeurological

Identifiers

PMID31582559
PMCPMC6899022
OpenAlexW2978959544

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.