ArticleClinical cancer research : an official journal of the American Association for Cancer Research2020
Molecular Imaging of Extracellular Tumor pH to Reveal Effects of Locoregional Therapy on Liver Cancer Microenvironment.
Article in Clinical cancer research : an official journal of the American Association for Cancer Research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
41 citing papers in PubMed, 61 citations in OpenAlex.
- Functionalized biomaterial platforms for interventional embolization therapy of hepatocellular carcinoma.Bioactive materials · 2027Review
- Longitudinal Multifrequency MR Elastography Reveals Biomechanical Signatures of Progression in a Translational Liver Tumor Model.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- High-Resolution Imaging of Extracellular pH in Mouse Liver Tumor.NMR in biomedicine · 2026Article
- Establishing selection criteria for male New Zealand white rabbits in interventional radiology research using organ volumes and vessel diameters.European radiology experimental · 2026Article
- Multiscale imaging on proton pump-driven acidity for assessing tumor progression and metastasis.Nature communications · 2026Article
- Homing and Detection of Unknown Primary Head-Neck Cancer by Acid-Sensing Nanoparticles.Research square · 2025Article
- Targeting lactic acidosis in the tumor microenvironment: Enhancing TACE efficacy in hepatocellular carcinoma.Liver research (Beijing, China) · 2025Review
- High-resolution quantitative mapping of extracellular pH by ratiometric MRI with iron chelates in a tumor mouse model.La Radiologia medica · 2025Article
- Recent Advances in mRNA Delivery Systems for Cancer Therapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- Magnesium microspheres for enhanced transarterial chemoembolization therapy of hepatocellular carcinoma: From animal models to a pilot clinical study.Science advances · 2025Article
- Advances in imaging techniques for tumor microenvironment evaluation in hepatocellular carcinoma.World journal of gastroenterology · 2025Review
- The Role of Glycocalyx Diversity and Thickness for Nanoparticle Internalization in M1-/M2-like Macrophages.Nano letters · 2024Article
- Interventional Oncology Meets Immuno-oncology: Combination Therapies for Hepatocellular Carcinoma.Radiology · 2024Review
- The Effects of Hypoxia on the Immune-Metabolic Interplay in Liver Cancer.Biomolecules · 2024Article
- Severely polarized extracellular acidity around tumour cells.Nature biomedical engineering · 2024Article
- Transmembrane pH gradient imaging in rodent glioma models.NMR in biomedicine · 2024Article
- Polyvinylpyrrolidone Assisted One-Pot Synthesis of Size-Tunable Cocktail Nanodrug for Multifunctional Combat of Cancer.International journal of nanomedicine · 2024Article
- Combination Therapy of Immune Checkpoint Inhibitors with Locoregional Therapy for Hepatocellular Carcinoma.Cancers · 2023Review
- Immune checkpoint inhibition: a future guided by radiology.The British journal of radiology · 2023Review
- Establishment of a rabbit liver metastasis model by percutaneous puncture of the spleen and implantation of the VX2 tumor strain under CT guidance.Scientific reports · 2023Article
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Authors and funding
15 authors at 1 institution in 2 countries.
Funding
Abstract
purposeTo establish magnetic resonance (MR)-based molecular imaging paradigms for the noninvasive monitoring of extracellular pH (pH EXPERIMENTAL
designThirty-two VX2 tumor-bearing New Zealand white rabbits underwent longitudinal imaging on clinical 3T-MRI and CT scanners before and up to 2 weeks after complete conventional transarterial chemoembolization (cTACE) using ethiodized oil (lipiodol) and doxorubicin. MR-spectroscopic imaging (MRSI) was employed for pH
resultsUntreated VX2 tumors demonstrated a significantly lower pH
conclusionsMRSI-based pH
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.