ArticleDevelopment (Cambridge, England)2019
GATA2 controls lymphatic endothelial cell junctional integrity and lymphovenous valve morphogenesis through
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Article in Development (Cambridge, England), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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32citing papers in PubMed
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32 citing papers in PubMed, 45 citations in OpenAlex.
- Mechanobiology of solid tumor vasculature: implications for tumor progression.Cancer metastasis reviews · 2026Review
- Loss of endothelial miR-126 drives age-related decline in hematopoiesis.Haematologica · 2026Article
- Metabolic Syndrome-Driven Changes in Cardiac Lymphatic Endothelium: mRNA Expression and Emerging Questions.Pathophysiology : the official journal of the International Society for Pathophysiology · 2026Article
- S1PR1 regulates lymphatic valve development and tertiary lymphoid organ formation in the ileum.The Journal of experimental medicine · 2025Article
- Circular RNAs increase during vascular cell differentiation and are biomarkers for vascular disease.Cardiovascular research · 2025Article
- Advances in etiology, pathophysiology, diagnosis, and management of lymphedema: a comprehensive review.Frontiers in medicine · 2025Review
- Exploring the genetic alterations of Gorham-Stout disease.Frontiers in endocrinology · 2025Review
- Characteristics and advances in signaling pathways, cellular communication, cell junctions, and oxidative stress in lymphedema.Frontiers in cell and developmental biology · 2025Review
- Endothelial cell transitions in zebrafish vascular development.Development, growth & differentiation · 2024Review
- Connexin-45 is expressed in mouse lymphatic endothelium and required for lymphatic valve function.JCI insight · 2024Article
- Localized Prox1 Regulates Aortic Valve Endothelial Cell Diversity and Extracellular Matrix Stratification in Mice.Arteriosclerosis, thrombosis, and vascular biology · 2023Article
- Single-nucleus multiregion transcriptomic analysis of brain vasculature in Alzheimer's disease.Nature neuroscience · 2023Article
- GATA2 regulates blood/lymph separation in a platelet-dependent and lymphovenous valve-independent manner.Microcirculation (New York, N.Y. : 1994) · 2023Article
- Buttons and Zippers: Endothelial Junctions in Lymphatic Vessels.Cold Spring Harbor perspectives in medicine · 2022Review
- Molecular Mechanisms Driving Lymphedema and Other Lymphatic Anomalies.Cold Spring Harbor perspectives in medicine · 2022Article
- Myeloid cell tropism enables MHC-E-restricted CD8Science immunology · 2022Article
- Back and forth: History of and new insights on the vertebrate lymphatic valve.Development, growth & differentiation · 2021Review
- Whole-mount Immunohistochemistry to Visualize Mouse Embryonic Dermal Lymphatic Vasculature.Bio-protocol · 2021Article
- Mutations in EPHB4 cause human venous valve aplasia.JCI insight · 2021Article
- Generation and characterization of cardiac valve endothelial-like cells from human pluripotent stem cells.Communications biology · 2021Article
Corrections and comments
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Authors and funding
20 authors at 7 institutions in 1 country.
Md Riaj MahamudCardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA.
Xin GengCardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA.
Yen-Chun HoCardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA.
Boksik ChaCardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA.
Yuenhee KimDepartment of Biological Sciences and Center for Systems Biology, The University of Texas at Dallas, Richardson, TX 75080, USA.
Jing MaDepartment of Cell and Molecular Biology, Tulane University, New Orleans, LA 70118, USA.
Lijuan ChenCardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA.
Greggory MyersDepartment of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Sally CamperDepartment of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Debbie MustacichDepartment of Surgery, University of Arizona, Tuscon, AZ 85724, USA.
Marlys WitteDepartment of Surgery, University of Arizona, Tuscon, AZ 85724, USA.
Dongwon ChoiDepartment of Surgery, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
Young-Kwon HongDepartment of Surgery, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
Hong ChenVascular Biology Program, Boston Children's Hospital, Boston, MA 02115, USA.
Gaurav VarshneyGenes & Human Disease Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA.ORCID 0000-0002-0429-1904
James Douglas EngelDepartment of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Shusheng WangDepartment of Cell and Molecular Biology, Tulane University, New Orleans, LA 70118, USA.
Tae-Hoon KimDepartment of Biological Sciences and Center for Systems Biology, The University of Texas at Dallas, Richardson, TX 75080, USA.
Kim-Chew LimDepartment of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA kclim@umich.edu sathish-srinivasan@omrf.org.ORCID 0000-0003-3992-3382
R Sathish SrinivasanCardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA kclim@umich.edu sathish-srinivasan@omrf.org.ORCID 0000-0002-4465-3340
Oklahoma Medical Research Foundation · USUniversity of Michigan · USThe University of Texas at Dallas · USTulane University · USUniversity of Arizona · USUniversity of Southern California · USBoston Children's Hospital · US
Funding
Understanding connective tissue development and disease with PDGFR-driven..... P20GM103636 · NIGMS · OKLAHOMA MEDICAL RESEARCH FOUNDATION · PI THOMPSON, LINDA F · 2013 to 2023
$26.9MTargeting Enzymatic Regulation of Fetal Hemoglobin RepressionP01HL146372 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ENGEL, JAMES DOUGLAS · 2019 to 2023
$10.9MInterdisciplinary research in vascular biologyP20GM103441 · NIGMS · OKLAHOMA MEDICAL RESEARCH FOUNDATION · PI MCEVER, RODGER PAUL · 2012 to 2014
$7.3MMolecular Mechanisms Controlling Lymphatic Vascular Function in Health and DiseaseR01HL133216 · NHLBI · BOSTON CHILDREN'S HOSPITAL · PI CHEN, HONG, DIXON, JAMES BRANDON · 2016 to 2025
$6.7MPilot ProjectP30GM114731 · NIGMS · OKLAHOMA MEDICAL RESEARCH FOUNDATION · PI MCEVER, RODGER PAUL · 2016 to 2020
$6.5MDefining the Mechanisms of Lymphatic Vascular Growth and FunctionR01HL131652 · NHLBI · OKLAHOMA MEDICAL RESEARCH FOUNDATION · PI SRINIVASAN, RAJANARAYANAN S · 2016 to 2025
$3.9MRegulation of Ocular Angiogenesis by microRNAsR01EY021862 · NEI · UT SOUTHWESTERN MEDICAL CENTER · PI WANG, SHUSHENG · 2011 to 2021
$2.8MMolecular Mechanisms Regulating Endothelial DysfunctionR01HL137229 · NHLBI · BOSTON CHILDREN'S HOSPITAL · PI CHEN, HONG, SRIVASTAVA, SANJAY · 2017 to 2020
$2.7MRole of long noncoding RNAs in human ocular angiogenesisR01EY026069 · NEI · TULANE UNIVERSITY OF LOUISIANA · PI WANG, SHUSHENG · 2016 to 2020
$1.9MThe Role of Signaling Adaptor Protein Epsin in AtherosclerosisR01HL118676 · NHLBI · OKLAHOMA MEDICAL RESEARCH FOUNDATION · PI CHEN, HONG · 2014 to 2017
$1.8MNEI NIH HHS R01 EY021862NEI NIH HHS R01 EY026069NHLBI NIH HHS P01 HL146372NHLBI NIH HHS R01 HL118676NHLBI NIH HHS R01 HL131652NHLBI NIH HHS R01 HL133216NHLBI NIH HHS R01 HL137229NIGMS NIH HHS P20 GM103441NIGMS NIH HHS P20 GM103636NIGMS NIH HHS P30 GM114731
Abstract
Mutations in the transcription factor GATA2 cause lymphedema. GATA2 is necessary for the development of lymphatic valves and lymphovenous valves, and for the patterning of lymphatic vessels. Here, we report that GATA2 is not necessary for valvular endothelial cell (VEC) differentiation. Instead, GATA2 is required for VEC maintenance and morphogenesis. GATA2 is also necessary for the expression of the cell junction molecules VE-cadherin and claudin 5 in lymphatic vessels. We identified
Indexed as
MutationAngiopoietin-2AnimalsCalcium-Binding ProteinsCell DifferentiationCell LineClaudin-5CRISPR-Cas SystemsEGF Family of ProteinsEndothelial CellsEndothelium, VascularFemaleGATA2 Transcription FactorGene DeletionHumansLymphatic VesselsAngiopoietin-2ANGPT2 protein, humanAngpt2 protein, mouseCalcium-Binding ProteinsClaudin-5CLDN5 protein, humanCldn5 protein, mouseEGF Family of ProteinsEGFL7 protein, humanEgfl7 protein, mouseGATA2 protein, humanGata2 protein, mouseGATA2 Transcription FactorMicroRNAsMIRN126 microRNA, humanMIRN126 microRNA, mouseClaudin 5GATA2Lymphatic vasculatureLymphovenous valvesmiR-126VE-cadherin
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.