Observational studyJACC. Heart failure2019
Lung Ultrasound in Acute Heart Failure: Prevalence of Pulmonary Congestion and Short- and Long-Term Outcomes.
Observational study in JACC. Heart failure, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05024942 (Lung Ultrasound in Aortic Stenosis Patients Undergoing Transcatheter Aortic Valve Replacement), which is not on this map. Cited by 101 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Lung Ultrasound in Aortic Stenosis Patients Undergoing Transcatheter Aortic Valve Replacement: a Prospective Study
Who cites it
101 citing papers in PubMed, 5 syntheses or guidelines pooled it, 173 citations in OpenAlex.
- Monitoring patients with acute dyspnea with serial point-of-care ultrasound of the inferior vena cava (IVC) and the lungs (LUS): a systematic review.Journal of ultrasound · 2022Pooled it
- Lung ultrasound-guided management to reduce hospitalization in chronic heart failure: a systematic review and meta-analysis.Heart failure reviews · 2022Pooled it
- Prevalence and prognostic importance of lung ultrasound findings in acute coronary syndrome: A systematic review.Echocardiography (Mount Kisco, N.Y.) · 2021Pooled it
- Recommendations for Lung Ultrasound in Internal Medicine.Diagnostics (Basel, Switzerland) · 2020Guideline
- Pooled it
- Lung ultrasound and diuretic therapy in chronic heart failure: a randomised trial.Clinical research in cardiology : official journal of the German Cardiac Society · 2024Trial
- Dapagliflozin vs. metolazone in heart failure resistant to loop diuretics.European heart journal · 2023Trial
- Impact of B-lines-guided intensive heart failure management on outcome of discharged heart failure patients with residual B-lines.ESC heart failure · 2022Trial
- Lung Ultrasound-Guided Emergency Department Management of Acute Heart Failure (BLUSHED-AHF): A Randomized Controlled Pilot Trial.JACC. Heart failure · 2021Trial
- Effect of Empagliflozin on Left Ventricular Volumes in Patients With Type 2 Diabetes, or Prediabetes, and Heart Failure With Reduced Ejection Fraction (SUGAR-DM-HF).Circulation · 2021 · on this mapTrial
- PaOCJC open · 2026Article
- Physiological Considerations in POCUS-Based Hemodynamic Assessment.Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine · 2026Article
- Cardiac Structure and Function and Pulmonary Congestion Across New York Heart Association Classes in Patients With Acute Heart Failure.Echocardiography (Mount Kisco, N.Y.) · 2026Observational
- Diuretics in Cardiovascular Disease: For How Long and at What Dose?Journal of cardiovascular development and disease · 2026Review
- ΔVExPLUs: prognostic value of integrating serial changes in VExUS score and lung ultrasound in acute decompensated heart failure.European heart journal. Imaging methods and practice · 2026Article
- Ultrasound-guided management in heart failure: A systematic review and meta-analysis evaluating lung and inferior vena cava ultrasound for reducing readmissions and mortality.American heart journal plus : cardiology research and practice · 2026Article
- International evidence-based recommendations for point-of-care lung ultrasound : 2025 focused update of the 2012 recommendations.Intensive care medicine · 2026Article
- Article
- Assessment of Point of Care Lung Ultrasound in the Ambulatory Heart Failure Setting.Clinical cardiology · 2026Article
- Assessing Venous Congestion in Heart Failure: A Review of Splanchnic, Cardiac, and Pulmonary Ultrasound: Part 2: Contrast-Enhanced Ultrasound and Shear Wave.Journal of clinical medicine · 2026Review
41 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
14 authors at 2 institutions in 2 countries.
Funding
Abstract
objectivesThis study sought to assess the prevalence, changes in, and prognostic importance of B-lines, a pulmonary congestion measure by using a simplified lung ultrasonography (LUS) method in acute heart failure (AHF).
backgroundPulmonary congestion is an important finding in AHF, but conventional methods for its detection are insensitive.
methodsIn a 2-site, prospective, observational study, 4-zone LUS was performed early during hospitalization for AHF (LUS1) and at discharge (LUS2). B-lines were quantified off-line, blinded to clinical findings and outcomes, by a core laboratory.
resultsAmong 349 patients (median, 75 years of age; 59% men; mean ejection fraction 39%), the sum of B-lines in 4 zones ranged from 0 to 18 (LUS1). The risk of an adverse in-hospital event increased with rising number of B-lines on LUS1: the odds ratio for each B-line tertile was 1.82 (95% confidence interval [CI]: 1.14 to 2.88; p = 0.011). B-line count decreased from a median of 6 (LUS1) to 4 (LUS2; p < 0.001) over 6 days (median). In 132 patients with LUS2 images, the risk of HF hospitalization or all-cause death was greater in patients with a higher number of B-lines at discharge. This relationship was stronger closer to discharge: unadjusted hazard ratio (HR) at 60 days was 3.30 (95% CI: 1.52 to 7.17; p = 0.002); 2.94 at 90 days (95% CI: 1.46 to 5.93; p = 0.003); and 2.01 at 180 days (95% CI: 1.11 to 3.64; p = 0.021). The association between number of B-lines and short- and long-term outcomes persisted after adjusting for important clinical variables, including N-terminal pro-B-type natriuretic peptide.
conclusionsPulmonary congestion using a simplified 4-zone LUS method was common in patients with AHF and improved with therapy. A higher number of B-lines at baseline and discharge identified patients at increased risk for adverse events.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.