Evidence map›Paper›PMID 31581897›Full record

SynthesisJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2019

The effect of angiopoietin-1 upregulation on the outcome of acute ischaemic stroke in rodent models: A meta-analysis.

Joseph V Moxon, Alexandra F Trollope, Brittany Dewdney, Catherine de Hollander, Domenico R Nastasi, Jane M Maguire, Jonathan Golledge

Open access · bronzeAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.

  1. Effect of uric acid in animal models of ischemic stroke: A systematic review and meta-analysis.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2021
    Pooled it
  2. Trial
  3. Article
  4. Review
  5. Article
  6. Ceruletide and Alpha-1 Antitrypsin as a Novel Combination Therapy for Ischemic Stroke.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2022
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Joseph V MoxonQueensland Research Centre for Peripheral Vascular Disease, James Cook University, Townsville, Australia.
Alexandra F TrollopeQueensland Research Centre for Peripheral Vascular Disease, James Cook University, Townsville, Australia.
Brittany DewdneyQueensland Research Centre for Peripheral Vascular Disease, James Cook University, Townsville, Australia.
Catherine de HollanderDepartment of Anatomy, James Cook University, Townsville, Australia.
Domenico R NastasiQueensland Research Centre for Peripheral Vascular Disease, James Cook University, Townsville, Australia.
Jane M MaguireFaculty of Health, University of Technology Sydney, Sydney, Australia.
Jonathan GolledgeQueensland Research Centre for Peripheral Vascular Disease, James Cook University, Townsville, Australia.
Australian Institute of Tropical Health and Medicine · AUJames Cook University · AUUniversity of Technology Sydney · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Clinical studies report that low circulating angiopoietin-1 concentration at presentation predicts worse outcomes after ischaemic stroke. Upregulating angiopoietin-1 may therefore have therapeutic benefit for ischaemic stroke. This systematic review assessed whether upregulating angiopoietin-1 improved outcomes in rodent models of ischaemic stroke. Random-effects models quantified the effect of angiopoietin-1 upregulation on stroke severity in terms of the size of cerebral infarction and the extent of blood-brain barrier permeability. Eleven studies utilising rat and mouse models of ischaemic stroke fulfilled the inclusion criteria. Meta-analyses demonstrated that angiopoietin-1 upregulation significantly reduced cerebral infarction size (standardised mean difference: -3.02; 95% confidence intervals: -4.41, -1.63;

Indexed as

Blood-Brain BarrierCerebral InfarctionStrokeUp-RegulationAngiopoietin-1AnimalsDisease Models, AnimalHumansMiceRatsAngiopoietin-1ANGPT1 protein, humanAngpt1 protein, mouseAngpt1 protein, ratangiopoietin-1blood–brain barrier permeabilitycerebral infarctionIschaemic strokerodent model

Identifiers

PMID31581897
PMCPMC6893985
OpenAlexW2977503526

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.