ArticleJournal of clinical medicine2019
Time Trends in the Incidence of Long-Term Mortality in T2DM Patients Who Have Undergone a Lower Extremity Amputation. Results of a Descriptive and Retrospective Cohort Study.
Article in Journal of clinical medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 18 citations in OpenAlex.
- Complications After the Use of Trans-Tibial Prostheses in Patients With Diabetes: A Cross-Sectional Study.Health science reports · 2026Article
- Inflammatory Biomarkers and Outcome Heterogeneity in Anti-MDA5 Antibody-Associated Interstitial Lung Disease: A Single-Center Consecutive Cohort Study.Advances in respiratory medicine · 2026Article
- Red blood cell distribution width is an independent predictor of mortality following amputation for diabetic foot.Scientific reports · 2025Article
- Relationship between diabetic peripheral neuropathy and adherence to the Mediterranean diet in patients with type 2 diabetes mellitus: an observational study.Journal of endocrinological investigation · 2024Observational
- Temporal trends in patients with peripheral artery disease influenced by diabetes mellitus in Germany.Journal of diabetes · 2022Article
- Analysis of Doppler ultrasonography and computer tomography angiography for predicting amputation level and re-amputation rate.Northern clinics of Istanbul · 2022Article
- Canagliflozin impedes ischemic hind-limb recovery in the setting of diabetes.Vascular medicine (London, England) · 2021Article
- Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio Predict Mortality in Patients with Diabetic Foot Ulcers Undergoing Amputations.Diabetes, metabolic syndrome and obesity : targets and therapy · 2021Article
- Survival at 10 years following lower extremity amputations in patients with diabetic foot disease.Endocrine · 2020Article
- Survival and factors predicting mortality after major and minor lower-extremity amputations among patients with diabetes: a population-based study using health information systems.BMJ open diabetes research & care · 2020Article
- Major amputations in type 2 diabetes between 2001 and 2015 in Spain: regional differences.BMC public health · 2020Observational
- Combining diabetic foot and retinopathy screening: A step in the right direction? - a feasibility study.SAGE open medicine · 2020Article
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 1 country.
Funding
Abstract
(1) Background: The aims of this study were to examine the incidence of lower extremity amputations (LEAs) among patients with type 2 diabetes mellitus (T2DM) and to compare the mortality risk of diabetic individuals who underwent LEA with age and sex-matched diabetic individuals without LEA. (2) Methods: We performed a descriptive observational study to assess the trend in the incidence of LEA and a retrospective cohort study to evaluate whether undergoing LEA is a risk factor for long-term mortality among T2DM patients. Data were obtained from the Hospital Discharge Database for the Autonomous Community of Madrid, Spain (2006-2015). (3) Results: The incidence rates of major below-knee and above-knee amputations decreased significantly from 24.9 to 17.1 and from 63.9 to 48.2 per 100000 T2DM individuals from 2006 to 2015, respectively. However, the incidence of minor LEAs increased over time. Mortality was significantly higher among T2DM patients who underwent LEA compared with those who did not undergo this procedure (HR 1.75; 95% CI 1.65-1.87). Male sex, older age, and comorbidity were independently associated with higher mortality after LEA. (4) Conclusions: Undergoing a LEA is a significant risk factor for long term mortality among T2DM patients, and those who underwent a major above-knee LEAs have the highest risk.
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