Evidence map›Paper›PMID 31581591›Full record

Trial reportNutrients2019

Effects of Leucine-Enriched Whey Protein Supplementation on Physical Function in Post-Hospitalized Older Adults Participating in 12-Weeks of Resistance Training Program: A Randomized Controlled Trial.

Maria Amasene, Ariadna Besga, Iñaki Echeverria, Miriam Urquiza, Jonatan R Ruiz, Ana Rodriguez-Larrad, Mikel Aldamiz, Pilar Anaut, Jon Irazusta, Idoia Labayen

Open access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Nutrients, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 13 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 13 pooled it
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 13 syntheses or guidelines pooled it, 48 citations in OpenAlex.

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  4. Effects of combined protein and exercise interventions on bone health in middle-aged and older adults - A systematic literature review and meta-analysis of randomized controlled trials.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2025
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  14. Trial
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Maria AmaseneDepartment of Pharmacy and Food Science, University of the Basque Country UPV/EHU, 01006 Vitoria-Gasteiz, Spain. maria.amasene@ehu.eus.
Ariadna BesgaDepartment of Medicine, Araba University Hospital, Bioaraba Research Institute, OSI Araba. CIBERSAM, University of the Basque Country (UPV/EHU), 01004 Vitoria-Gasteiz, Spain. ariadna.besgabasterra@osakidetza.eus.
Iñaki EcheverriaDepartment of Physiology, University of the Basque Country, UPV/EHU, 48940 Leioa, Spain. inaki.echeverriag@ehu.eus.ORCID 0000-0002-1042-4494
Miriam UrquizaDepartment of Physiology, University of the Basque Country, UPV/EHU, 48940 Leioa, Spain. miriam.urquiza@ehu.eus.
Jonatan R RuizPROFITH "PROmoting FITness and Health through physical activity" Research Group, Sport and Health University Research Institute (iMUDS), Department of Physical Education and Sport, Faculty of Sport Sciences, University of Granada, 18071 Granada, Spain. ruizj@ugr.es.
Ana Rodriguez-LarradDepartment of Physiology, University of the Basque Country, UPV/EHU, 48940 Leioa, Spain. ana.rodriguez@ehu.eus.ORCID 0000-0003-0923-0788
Mikel AldamizDepartment of Medicine, Araba University Hospital, Bioaraba Research Institute, OSI Araba. CIBERSAM, University of the Basque Country (UPV/EHU), 01004 Vitoria-Gasteiz, Spain. mikel.aldamiz-echebarriasansebastian@osakidetza.eus.
Pilar AnautDepartment of Medicine, Araba University Hospital, Bioaraba Research Institute, OSI Araba. CIBERSAM, University of the Basque Country (UPV/EHU), 01004 Vitoria-Gasteiz, Spain. mariapilar.anautmayo@osakidetza.eus.
Jon IrazustaDepartment of Physiology, University of the Basque Country, UPV/EHU, 48940 Leioa, Spain. jon.irazusta@ehu.eus.
Idoia LabayenELIKOS group, Institute for Innovation and Sustainable Development in Food Chain (IS-FOOD), Public University of Navarra, 31006 Pamplona, Spain. idoia.labayen@unavarra.es.ORCID 0000-0002-4334-3287
University of the Basque Country · ESUniversidad de Granada · ESUniversidad Publica de Navarra · ES

Funding

Euskal Herriko Unibertsitatea PIF17/186Osasun Saila, Eusko Jaurlaritzako 2016111138
6 · The paper itself

Abstract

Age-related strength and muscle mass loss is further increased after acute periods of inactivity. To avoid this, resistance training has been proposed as an effective countermeasure, but the additional effect of a protein supplement is not so clear. The aim of this study was to examine the effect of a whey protein supplement enriched with leucine after resistance training on muscle mass and strength gains in a post-hospitalized elderly population. A total of 28 participants were included and allocated to either protein supplementation or placebo supplementation following resistance training for 12 weeks (2 days/week). Physical function (lower and upper body strength, aerobic capacity and the Short Physical Performance Battery (SPPB) test), mini nutritional assessment (MNA) and body composition (Dual X-ray Absorptiometry) were assessed at baseline and after 12 weeks of resistance training. Both groups showed improvements in physical function after the intervention (

Indexed as

Dietary SupplementsMuscle ContractionMuscle StrengthResistance TrainingAgedAged, 80 and overAge FactorsFemaleHumansLeucineMaleMuscle, SkeletalNutritional StatusNutritive ValuePatient DischargeProspective StudiesLeucineWhey Proteinsagingelderlyleucinemuscle massprotein supplementationresistance trainingstrengthwhey protein

Identifiers

PMID31581591
PMCPMC6835698
OpenAlexW2978723359

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.