Evidence map›Paper›PMID 31581590›Full record

ArticlePathogens (Basel, Switzerland)2019

Withanolides from

Atteneri López-Arencibia, Desirée San Nicolás-Hernández, Carlos J Bethencourt-Estrella, Ines Sifaoui, María Reyes-Batlle, Rubén L Rodríguez-Expósito, Aitor Rizo-Liendo, Jacob Lorenzo-Morales, Isabel L Bazzocchi, José E Piñero and 1 more

Open access · goldAbstract read
In one paragraph

Article in Pathogens (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
3.2field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 19 citations in OpenAlex.

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  4. Discovery of New Chemical Tools againstPharmaceuticals (Basel, Switzerland) · 2021
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  5. Article
  6. Acrylonitrile Derivatives againstPharmaceuticals (Basel, Switzerland) · 2021
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  7. Antimicrobial agents and chemotherapy · 2021
    Article
  8. Emerging Parasitic Protozoa.Pathogens (Basel, Switzerland) · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Atteneri López-ArencibiaInstituto Universitario de Enfermedades Tropicales y Salud Pública de Canarias, Universidad de La Laguna, Avda. Astrofısico Fco. Sanchez, S/N, 38203 La Laguna, Tenerife, Canary Islands, Spain. atlopez@ull.edu.es.
Desirée San Nicolás-HernándezInstituto Universitario de Enfermedades Tropicales y Salud Pública de Canarias, Universidad de La Laguna, Avda. Astrofısico Fco. Sanchez, S/N, 38203 La Laguna, Tenerife, Canary Islands, Spain. unidesi@hotmail.com.
Carlos J Bethencourt-EstrellaInstituto Universitario de Enfermedades Tropicales y Salud Pública de Canarias, Universidad de La Laguna, Avda. Astrofısico Fco. Sanchez, S/N, 38203 La Laguna, Tenerife, Canary Islands, Spain. carlosbethencourtestrella@gmail.com.
Ines SifaouiInstituto Universitario de Enfermedades Tropicales y Salud Pública de Canarias, Universidad de La Laguna, Avda. Astrofısico Fco. Sanchez, S/N, 38203 La Laguna, Tenerife, Canary Islands, Spain. ines.sifaoui@hotmail.com.
María Reyes-BatlleInstituto Universitario de Enfermedades Tropicales y Salud Pública de Canarias, Universidad de La Laguna, Avda. Astrofısico Fco. Sanchez, S/N, 38203 La Laguna, Tenerife, Canary Islands, Spain. mreyesba@ull.edu.es.
Rubén L Rodríguez-ExpósitoInstituto Universitario de Enfermedades Tropicales y Salud Pública de Canarias, Universidad de La Laguna, Avda. Astrofısico Fco. Sanchez, S/N, 38203 La Laguna, Tenerife, Canary Islands, Spain. ruben_rguez_exposito92@hotmail.com.
Aitor Rizo-LiendoInstituto Universitario de Enfermedades Tropicales y Salud Pública de Canarias, Universidad de La Laguna, Avda. Astrofısico Fco. Sanchez, S/N, 38203 La Laguna, Tenerife, Canary Islands, Spain. aitorrizo@gmail.com.
Jacob Lorenzo-MoralesInstituto Universitario de Enfermedades Tropicales y Salud Pública de Canarias, Universidad de La Laguna, Avda. Astrofısico Fco. Sanchez, S/N, 38203 La Laguna, Tenerife, Canary Islands, Spain. jmlorenz@ull.edu.es.
Isabel L BazzocchiInstituto Universitario de Bio-Orgánica Antonio González, Departamento de Química Orgánica, Universidad de La Laguna, Avenida Astrofísico Francisco Sánchez 2, 38206 La Laguna, Tenerife, Canary Islands, Spain. ilopez@ull.edu.es.
José E PiñeroInstituto Universitario de Enfermedades Tropicales y Salud Pública de Canarias, Universidad de La Laguna, Avda. Astrofısico Fco. Sanchez, S/N, 38203 La Laguna, Tenerife, Canary Islands, Spain. jpinero@ull.edu.es.
Ignacio A JiménezInstituto Universitario de Bio-Orgánica Antonio González, Departamento de Química Orgánica, Universidad de La Laguna, Avenida Astrofísico Francisco Sánchez 2, 38206 La Laguna, Tenerife, Canary Islands, Spain. ignadiaz@ull.edu.es.
Universidad de La Laguna · ES

Funding

PREVENTIVE ONCOLOGY ACADEMIC AWARDK07CA001380 · NCI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI GILCHREST, BARBARA A · 1988 to 1992
–
Ministerio de Ciencia, Innovación y Universidades PI18/01380Ministerio de Ciencia, Innovación y Universidades RD16/0027/0001Ministerio de Economía y Empresa RTI2018-094356-B-C21
6 · The paper itself

Abstract

Leishmaniasis and American trypanosomiasis are parasitic diseases that cause significant clinical, social and economic impact on the population of tropical and subtropical countries. Their current treatment is limited and presents multiple drawbacks, including high toxicity, high cost, lengthy treatment plans, as well as the emergence of resistant species. Therefore, there is a need to find new lead compounds with high potency against parasites and low toxicity in patients. In the present work, the bioguided fractionation of an endemic plant from the Canary Islands,

Indexed as

apoptosis-likeLeishmaniaTrypanosomaWithania aristatawithanolides

Identifiers

PMID31581590
PMCPMC6963971
OpenAlexW2977300684

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.