ArticleJournal of clinical medicine2019
Growth Differentiation Factor-15 (GDF-15) is a Biomarker of Muscle Wasting and Renal Dysfunction in Preoperative Cardiovascular Surgery Patients.
Article in Journal of clinical medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 51 citations in OpenAlex.
- Growth differentiation factor 15: from stress response to clinical utility in chronic liver diseases.Journal of gastroenterology · 2026Review
- Phase Angle Shows a Negative Correlation With Serum GDF-15 Concentrations in Hospitalized Patients With Cardiovascular Disease.Journal of nutrition and metabolism · 2026Article
- Evaluation of potential mechanisms for skeletal muscle mass recovery early after left ventricular assist device implantation.JHLT open · 2025Article
- Article
- Circulating Muscle Markers for Sarcopenia in Peritoneal Dialysis.International journal of nephrology · 2025Review
- GDF-15 as a proxy for epigenetic aging: associations with biological age markers, and physical function.Biogerontology · 2024Article
- Article
- Pathophysiological roles of the serum acylcarnitine level and acylcarnitine/free carnitine ratio in patients with cardiovascular diseases.International journal of cardiology. Heart & vasculature · 2024Article
- CAN WE DIAGNOSE SARCOPENIA USING ANTERIOR FEMORAL MUSCLE THICKNESS IN PATIENTS WITH CARDIOVASCULAR DISEASE?Journal of rehabilitation medicine. Clinical communications · 2024Article
- Clinical usefulness of phase angle as an indicator of muscle wasting and malnutrition in inpatients with cardiovascular diseases.Asia Pacific journal of clinical nutrition · 2023Article
- Mitochondrial stress and mitokines in aging.Aging cell · 2023Review
- The Cytokine Growth Differentiation Factor-15 and Skeletal Muscle Health: Portrait of an Emerging Widely Applicable Disease Biomarker.International journal of molecular sciences · 2022Review
- Association between serum GDF-15, myostatin, and sarcopenia in cardiovascular surgery patients.International journal of cardiology. Heart & vasculature · 2022Article
- Relationship between the serum GDF-15 concentration and muscle function in female patients receiving aortic valve replacement (TAVR, SAVR): Comparison with healthy elderly female subjects.International journal of cardiology. Heart & vasculature · 2022Article
- High serum concentrations of growth differentiation factor-15 and their association with Crohn's disease and a low skeletal muscle index.Scientific reports · 2022Article
- Negative Regulators of Inflammation Response to the Dynamic Expression of Cytokines in DF-1 and MDCK Cells Infected by Avian Influenza Viruses.Inflammation · 2022Article
- Serum levels of the cold stress hormones FGF21 and GDF-15 after cardiac arrest in infants and children enrolled in single center therapeutic hypothermia clinical trials.Resuscitation · 2022Article
- Growth Differentiation Factor-15 as a Biomarker for Sarcopenia in Patients With Chronic Obstructive Pulmonary Disease.Frontiers in nutrition · 2022Article
- Circulating Levels of Apelin, GDF-15 and Sarcopenia: Lack of Association in the MAPT Study.The journal of nutrition, health & aging · 2022Article
- Serum growth differentiation factor-15 analysis as a malnutrition marker in hemodialysis patientsTurkish journal of medical sciences · 2021Article
Corrections and comments
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Authors and funding
16 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Frailty and sarcopenia increase the risk of complications and mortality when invasive treatment such as cardiac surgery is performed. Growth differentiation factor-15 (GDF-15) involves various pathophysiological conditions including renal dysfunction, heart failure and cachexia. We investigated the pathophysiological roles of preoperative GDF-15 levels in cardiovascular surgery patients. Preoperative skeletal muscle index (SMI) determined by bioelectrical impedance analysis, hand-grip strength, 4 m gait speed, and anterior thigh muscle thickness (TMth) measured by echocardiography were assessed in 72 patients (average age 69.9 years) who underwent cardiovascular surgery. The preoperative serum GDF-15 concentration was determined by enzyme-linked immunosorbent assay. Circulating GDF-15 level was correlated with age, brain natriuretic peptide, and estimated glomerular filtration rate (eGFR). It was also negatively correlated with SMI, hand-grip strength, and anterior TMth. In multivariate analysis, eGFR and anterior TMth were the independent determinants of GDF-15 concentration even after adjusting for age, sex, and body mass index. Alternatively, the GDF-15 level was an independent determinant of eGFR and anterior TMth. We concluded that preoperative GDF-15 levels reflect muscle wasting as well as renal dysfunction in preoperative cardiovascular surgery patients. GDF-15 may be a novel biomarker for identify high-risk patients with muscle wasting and renal dysfunction before cardiovascular surgery.
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