Evidence map›Paper›PMID 31581548›Full record

ArticleCells2019

Clonal Evolution of

Marica Garziera, Erika Cecchin, Giorgio Giorda, Roberto Sorio, Simona Scalone, Elena De Mattia, Rossana Roncato, Sara Gagno, Elena Poletto, Loredana Romanato and 3 more

Open access · goldAbstract readCase Reports
In one paragraph

Article in Cells, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Oncology reports · 2023
    Article
  5. Article
  6. Article
  7. Article
  8. Purified Tea (International journal of molecular sciences · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Marica GarzieraExperimental and Clinical Pharmacology Unit, Centro di Riferimento Oncologico (CRO), IRCCS, 33081 Aviano, Italy. mgarziera@cro.it.ORCID 0000-0001-6902-210X
Erika CecchinExperimental and Clinical Pharmacology Unit, Centro di Riferimento Oncologico (CRO), IRCCS, 33081 Aviano, Italy. ececchin@cro.it.ORCID 0000-0001-7517-7490
Giorgio GiordaGynecological Oncology Unit, Centro di Riferimento Oncologico (CRO), IRCCS, 33081 Aviano, Italy. ggiorda@cro.it.
Roberto SorioMedical Oncology Unit C, Centro di Riferimento Oncologico (CRO), IRCCS, 33081 Aviano, Italy. rsorio@cro.it.
Simona ScaloneMedical Oncology Unit C, Centro di Riferimento Oncologico (CRO), IRCCS, 33081 Aviano, Italy. sscalone@cro.it.
Elena De MattiaExperimental and Clinical Pharmacology Unit, Centro di Riferimento Oncologico (CRO), IRCCS, 33081 Aviano, Italy. edemattia@cro.it.ORCID 0000-0003-4948-8767
Rossana RoncatoExperimental and Clinical Pharmacology Unit, Centro di Riferimento Oncologico (CRO), IRCCS, 33081 Aviano, Italy. rroncato@cro.it.
Sara GagnoExperimental and Clinical Pharmacology Unit, Centro di Riferimento Oncologico (CRO), IRCCS, 33081 Aviano, Italy. sgagno@cro.it.
Elena PolettoMedical Oncology, "Santa Maria della Misericordia" University Hospital, ASUIUD, 33100 Udine, Italy. polettoelena@libero.it.
Loredana RomanatoExperimental and Clinical Pharmacology Unit, Centro di Riferimento Oncologico (CRO), IRCCS, 33081 Aviano, Italy. lromanato@cro.it.
Fabrizio EccaExperimental and Clinical Pharmacology Unit, Centro di Riferimento Oncologico (CRO), IRCCS, 33081 Aviano, Italy. fabrizio.ecca@cro.it.ORCID 0000-0002-4525-1626
Vincenzo CanzonieriPathology Unit, Centro di Riferimento Oncologico (CRO), IRCCS, 33081 Aviano, Italy. vcanzonieri@cro.it.ORCID 0000-0001-6010-0976
Giuseppe ToffoliExperimental and Clinical Pharmacology Unit, Centro di Riferimento Oncologico (CRO), IRCCS, 33081 Aviano, Italy. gtoffoli@cro.it.ORCID 0000-0002-5323-4762
Centro di Riferimento Oncologico · ITOspedale Santa Maria della Misericordia di Udine · ITUniversity of Trieste · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Carboplatin/paclitaxel is the reference regimen in the treatment of advanced high-grade serous ovarian cancer (HGSOC) in neo-adjuvant chemotherapy (NACT) before interval debulking surgery (IDS). To identify new genetic markers of platinum-resistance, next-generation sequencing (NGS) analysis of 26 cancer-genes was performed on paired matched pre- and post-NACT tumor and blood samples in a patient with stage IV HGSOC treated with NACT-IDS, showing platinum-refractory/resistance and poor prognosis. Only the

Indexed as

Clonal EvolutionBiomarkers, TumorChemotherapy, AdjuvantCystadenocarcinoma, SerousFemaleHumansMiddle AgedMutationNeoadjuvant TherapyOvarian NeoplasmsTumor Suppressor Protein p53Biomarkers, TumorTP53 protein, humanTumor Suppressor Protein p53chemoresistanceHGSOCNACTNGSTP53

Identifiers

PMID31581548
PMCPMC6829309
OpenAlexW2979133747

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.