ArticleJournal of diabetes investigation2020
Absolute risk of acute coronary syndrome after severe hypoglycemia: A population-based 2-year cohort study using the National Database in Japan.
Article in Journal of diabetes investigation, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 29 citations in OpenAlex.
- Article
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- Review Article - Diabetes Technology in the Hospital: An Update.Current diabetes reports · 2024Review
- Literature Review of Studies Using the National Database of the Health Insurance Claims of Japan (NDB): Limitations and Strategies in Using the NDB for Research.JMA journal · 2024Review
- Nomogram for Predicting Hypoglycemia in Type 2 Diabetes Mellitus Patients Treated with Insulin Pump During Enteral Nutrition.Diabetes, metabolic syndrome and obesity : targets and therapy · 2024Article
- A nationwide epidemiological study of testicular torsion: Analysis of the Japanese National Database.PloS one · 2024Article
- Economic burden of cancer attributable to modifiable risk factors in Japan.Global health & medicine · 2023Article
- Article
- Risk of Lactic Acidosis in Hospitalized Diabetic Patients Prescribed Biguanides in Japan: A Retrospective Total-Population Cohort Study.International journal of environmental research and public health · 2023Article
- The age of death in Japanese patients with type 2 and type 1 diabetes: A descriptive epidemiological study.Journal of diabetes investigation · 2022Article
- Cardiovascular disease in patients with type 2 diabetes.Journal of diabetes investigation · 2022Article
- Appropriate definition of diabetes using an administrative database: A cross-sectional cohort validation study.Journal of diabetes investigation · 2022Article
- A nationwide survey on participation in cardiac rehabilitation among patients with coronary heart disease using health claims data in Japan.Scientific reports · 2021Article
- Association between influenza and the incidence rate of new-onset type 1 diabetes in Japan.Journal of diabetes investigation · 2021Article
- Incidence of lower limb amputation in people with and without diabetes: a nationwide 5-year cohort study in Japan.BMJ open · 2021Article
- Long-term prognosis of enteral feeding and parenteral nutrition in a population aged 75 years and older: a population-based cohort study.BMC geriatrics · 2021Article
- Inpatient Hypoglycemia: The Challenge Remains.Journal of diabetes science and technology · 2020Review
- Absolute risk of acute coronary syndrome after severe hypoglycemia: A population-based 2-year cohort study using the National Database in Japan.Journal of diabetes investigation · 2020Article
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
AIMS/
introductionAlthough the epidemiological relationship between hypoglycemia and increased risk of acute coronary syndrome (ACS) has been well established, the time period for increased risk of ACS after a severe hypoglycemic episode remains unknown. The present study aimed to determine the ACS risk after a severe hypoglycemic episode. MATERIALS AND
methodsWe carried out a retrospective population-based cohort study based on national claims data in Japan. We retrieved data of diabetes patients aged ≥35 years collected from April 2014 to March 2016. The absolute risk of ACS was defined as the occurrence of an emergency percutaneous coronary intervention after a severe hypoglycemic episode.
resultsIn total, data of 7,909,626 patients were included in the analysis. The absolute risk of ACS was 2.9 out of 1,000 person-years in all patients. ACS risk in patients with severe hypoglycemic episodes was 3.0 out of 1,000 person-years. Severe hypoglycemic episodes increased the absolute risk of ACS in patients aged ≥70 years, but not in patients aged <70 years. The absolute risk of ACS was 10.6 out of 1,000 person-years within 10 days of a severe hypoglycemic episode. There was a significant trend between shorter duration after an episode and higher ACS risk.
conclusionsSevere hypoglycemia was associated with an increased risk of ACS in elderly diabetes patients. ACS risk increased with a shorter period after a severe hypoglycemic episode, suggesting that severe hypoglycemia leads to an increased risk of ACS in diabetes patients. These findings show that it is important to avoid severe hypoglycemia while treating diabetes, particularly in elderly patients.
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