ReviewPediatric research2020
Review of bilirubin neurotoxicity II: preventing and treating acute bilirubin encephalopathy and kernicterus spectrum disorders.
Review in Pediatric research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 43 citations in OpenAlex.
- Parenteral Lipid Dose and Bilirubin Neurotoxicity in Extremely Preterm Infants: A Factorial Randomized Trial.The Journal of pediatrics · 2026Trial
- Point-of-care serum bilirubin as an efficient and comparable alternative to hospital based testing.Pediatric research · 2026Article
- The impact of prematurity and neonatal complications on hearing function in children born to HIV-Positive mothers: A secondary data analysis in the South African context.BMC pediatrics · 2025Article
- In situ growth of luminescent d-f MOF nanostructures on bacterial cellulose as an accessible kit for early jaundice diagnosis.Scientific reports · 2025Article
- Risk factors associated with hearing loss in neonates: A retrospective cross-sectional study from Qatar.Qatar medical journal · 2025Article
- Changes in the Gut Microbiota of Neonates with Hyperbilirubinemia Reaching Phototherapy Thresholds.International journal of general medicine · 2025Article
- Automatic deep learning method for analysis and prediction of neonatal hyperbilirubinemia in magnetic resonance imaging.Quantitative imaging in medicine and surgery · 2024Article
- Neonatal phototherapy and risk of epilepsy-A Danish population based study.European journal of pediatrics · 2024Article
- Exchange Transfusion Trends and Risk Factors for Extreme Neonatal Hyperbilirubinemia over 10 Years in Shiraz, Iran.Iranian journal of medical sciences · 2024Article
- Experiences with neonatal jaundice management in hospitals and the community: interviews with Australian health professionals.BMJ open · 2024Article
- Developmental outcome of neonates underwent exchange transfusion due to hyperbilirubinemia: A single-center experience.Journal of education and health promotion · 2024Article
- Effects of Repetitive Transcranial Magnetic Stimulation on Pallidum GABAergic Neurons and Motor Function in Rat Models of Kernicterus.Brain sciences · 2023Article
- Models of bilirubin neurological damage: lessons learned and new challenges.Pediatric research · 2023Review
- Neonatal Phototherapy and Clinical Characteristics: The Danish National Patient Registry 2000-2016.Clinical epidemiology · 2023Article
- Kernicterus Spectrum Disorders Diagnostic Toolkit: validation using retrospective chart review.Pediatric research · 2022Article
- Effect of Massage Therapy for the Treatment of Neonatal Jaundice: A Systematic Review and Dose-Response Meta-analysis.International journal of pediatrics · 2022Review
- Complex dystonias: an update on diagnosis and care.Journal of neural transmission (Vienna, Austria : 1996) · 2021Review
- Curcumin Prevents Cerebellar Hypoplasia and Restores the Behavior in Hyperbilirubinemic Gunn Rat by a Pleiotropic Effect on the Molecular Effectors of Brain Damage.International journal of molecular sciences · 2020Article
- Bilirubin Induced Encephalopathy.Iranian journal of child neurology · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Previously in Part I of this two-part review, we discussed the current and recent advances in the understanding of the molecular biology and neuropathology of bilirubin neurotoxicity (BNTx). Here in Part II, we summarize current treatment options available to treat the severely jaundiced infants to prevent significant brain damage and improve clinical outcomes. In addition, we review potential novel therapies that are in various stages of research and development. We will emphasize treatments for both prevention and treatment of both acute bilirubin encephalopathy (ABE) and kernicterus spectrum disorders (KSDs), highlighting the treatment of the most disabling neurological sequelae of children with mild-to-severe KSDs whose "rare disease" status often means they are overlooked by the clinical research community at large. As with other secondary dystonias, treatment of the dystonic motor symptoms in kernicterus is the greatest clinical challenge.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.