Evidence map›Paper›PMID 31580981›Full record

ArticleForensic science international2019

What's in the bag? Analysis of exterior drug packaging by TD-DART-MS to predict the contents.

Edward Sisco, Elizabeth L Robinson, Amber Burns, Rebecca Mead

Open access · greenAbstract read
In one paragraph

Article in Forensic science international, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
5.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 38 citations in OpenAlex.

  1. Article
  2. Applications of DESI and DART Mass Spectrometry in Forensic Science.Journal of the American Society for Mass Spectrometry · 2025
    Review
  3. Article
  4. Article
  5. Clinical Chemistry for Developing Countries: Mass Spectrometry.Annual review of analytical chemistry (Palo Alto, Calif.) · 2021
    Review
  6. Creation and Release of an Updated NIST DART-MS Forensics Database.Journal of the American Society for Mass Spectrometry · 2021
    Article
  7. Forensic applications of DART-MS: A review of recent literature.Forensic chemistry (Amsterdam, Netherlands) · 2021
    Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Edward SiscoNational Institute of Standards and Technology, 100 Bureau Drive, Gaithersburg, MD 20899, USA. Electronic address: edward.sisco@nist.gov.
Elizabeth L RobinsonNational Institute of Standards and Technology, 100 Bureau Drive, Gaithersburg, MD 20899, USA. Electronic address: elizabeth.l.robinson@nist.gov.
Amber BurnsMaryland State Police Forensic Sciences Division, 221 Milford Mill Road, Pikesville, MD 21208, USA. Electronic address: amber.burns@maryland.gov.
Rebecca MeadVermont Forensic Laboratory, 45 State Drive, Waterbury, VT 05676, USA. Electronic address: rebecca.mead@vermont.gov.
National Institute of Standards and Technology · USMichigan State Police · USVermont State Hospital · US

Funding

Intramural NIST DOC 9999-NIST
6 · The paper itself

Abstract

The need for a safe and reliable presumptive test for law enforcement, first responders, and laboratory personnel is critical in the era of dangerous synthetic opioids and other novel psychoactive substances. Obtaining drug identification information without handling bulk powder is one way of accomplishing this task. This work evaluates whether trace residue on the exterior of drug packaging presents a potential source for presumptive testing. Utilizing a wipe-based approach, the outside of the packaging of nearly 200 case exhibits were sampled and analyzed by thermal desorption direct analysis in real time mass spectrometry (TD-DART-MS). While residue on the law enforcement (outer) packaging was a poor indicator of the contents (less than 50% accurate), the exterior of the drug (inner) packaging was shown to be an excellent indicator of its contents (92% accurate). Quantitative analysis of the wipes, using liquid chromatography mass spectrometry (LC-MS/MS) showed that typical masses of residue on the exterior of packaging ranged from single to tens of micrograms - enough for detection by a number of trace detection tools. These initial results demonstrate that wipe-based trace sampling approaches present a promising, reliable, and safe method for presumptive testing by law enforcement, first responders, or laboratory personnel.

Indexed as

DART-MSDrug evidenceOpioidsPresumptive testingTrace detection

Identifiers

PMID31580981
PMCPMC6988774
OpenAlexW2972698947

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.