Trial reportBrain, behavior, and immunity2020
Effects of stress-induced inflammation on reward processing in healthy young women.
Trial report in Brain, behavior, and immunity, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03828604 (Stress-Induced Inflammation and Reward Processing), which is not on this map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Stress-Induced Inflammation and Reward Processing
Who cites it
19 citing papers in PubMed.
- Inflammation-induced depressed mood and reward responsivity as a function of age in female adults: a randomized controlled trial of endotoxin.Translational psychiatry · 2025Trial
- Effects of a mild inflammatory challenge on cytokines and sickness behavior: A randomized controlled trial using the influenza vaccine.Brain, behavior, and immunity · 2025Trial
- Probing biomarkers and clinical utility of reward learning across species using the Probabilistic Reward Task: 20 years of findings.Nature. Mental health · 2026Article
- Socioeconomic Status Is Associated With Reward Processing, Interleukin 1β, Striatal Connectivity, and Antidepressant Outcomes in Individuals With Major Depressive Disorder: A CAN-BIND-1 Report.Biological psychiatry global open science · 2026Article
- Estrous cycle stage gates the effect of stress on reward learning.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Greater fatigue is more strongly associated with reduced reward sensitivity in the long-term phase of coronavirus disease (COVID-19) than in the early phase.Brain, behavior, & immunity - health · 2025Article
- Association between sleep disorder and anhedonia in adolescence with major depressive disorder: the mediating effect of stress.BMC psychiatry · 2024Article
- Effects of acute stress on reward processing: A comprehensive meta-analysis of rodent and human studies.Neurobiology of stress · 2024Review
- Immunosenescence and Inflamm-Aging: Clinical Interventions and the Potential for Reversal of Aging.Cureus · 2024Review
- Stress to inflammation and anhedonia: Mechanistic insights from preclinical and clinical models.Neuroscience and biobehavioral reviews · 2023Review
- The role of inflammation in acute psychosocial stress-induced modulation of reward processing in healthy female adults.Brain, behavior, & immunity - health · 2023Article
- The role of early life adversity and inflammation in stress-induced change in reward and risk processes among adolescents.Brain, behavior, and immunity · 2023Article
- Psychological measures of stress and biomarkers of inflammation, aging, and endothelial dysfunction in breast cancer survivors on aromatase inhibitors.Scientific reports · 2023Article
- Role of amygdala in stress-induced upregulation of airway IL-1 signaling in asthma.Biological psychology · 2022Article
- The Stressed Brain: Neural Underpinnings of Social Stress Processing in Humans.Current topics in behavioral neurosciences · 2022Review
- Beyond social withdrawal: New perspectives on the effects of inflammation on social behavior.Brain, behavior, & immunity - health · 2021Article
- Effects of Appetitive and Aversive Motivational States on Wanting and Liking of Interpersonal Touch.Neuroscience · 2021Article
- Goal-striving tendencies moderate the relationship between reward-related brain function and peripheral inflammation.Brain, behavior, and immunity · 2021Article
- Aging as a Context for the Role of Inflammation in Depressive Symptoms.Frontiers in psychiatry · 2020Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
backgroundAnhedonia, or loss of interest or pleasure, is a feature of depression and transdiagnostic construct in psychopathology. Theory and compelling evidence from preclinical models implicates stress-induced inflammation as a psychobiological pathway to anhedonic behavior; however, this pathway has not been tested in human models. Further, although anhedonia may reflect dysregulation in multiple dimensions of reward, the extent to which stress-induced inflammation alters these dimensions is unclear. Thus, the current experimental study used a standardized laboratory stressor task to elicit an inflammatory response and evaluate effects of stress-induced inflammation on multiple behavioral indices of reward processing.
methodsHealthy young women (age 18-25) completed behavioral reward tasks assessing reward learning, motivation, and sensitivity and were randomized to undergo an acute psychosocial stressor (n = 37) or a no-stress active control (n = 17). Tasks were re-administered 90-120 min post-stress to coincide with the peak of the stress-induced inflammatory response. Blood samples were collected for assessment of the pro-inflammatory cytokine interleukin-6 (IL-6) at baseline and 90 and 120 min post stressor.
resultsStress-induced IL-6 was associated with increased response bias during reward learning and increased motivation when probability of receiving a reward was low. Sensitivity to reward in the context of a motivation task was not altered in association with stress-induced IL-6.
conclusionsContrary to hypotheses, mild increases in IL-6 following acute stress were associated with increased reward responsiveness during reward learning and selective increases in motivation. Results contribute to an emerging and nuanced literature linking inflammation to reward processing, and demonstrate that behavioral effects of stress-induced inflammation may be detected in the laboratory setting. CLINICAL
trial registrationNCT03828604.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.