Evidence map›Paper›PMID 31580658›Full record

ArticleJournal of medicinal chemistry2019

Theranostic Gallium Siderophore Ciprofloxacin Conjugate with Broad Spectrum Antibiotic Potency.

Apurva Pandey, Chloé Savino, Shin Hye Ahn, Zhaoyong Yang, Steven G Van Lanen, Eszter Boros

Abstract read
In one paragraph

Article in Journal of medicinal chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
2.9field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 79 citations in OpenAlex.

  1. Review
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  3. Article
  4. Article
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  6. Article
  7. Review
  8. Review
  9. Article
  10. Review
  11. Gallium Resistance inApplied microbiology (Basel, Switzerland) · 2025
    Article
  12. Review
  13. Review
  14. Review
  15. Article
  16. Review
  17. Siderophores as tools and treatments.npj antimicrobials and resistance · 2024
    Review
  18. Article
  19. Article
  20. Metals to combat antimicrobial resistance.Nature reviews. Chemistry · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Apurva PandeyDepartment of Chemistry , Stony Brook University , 100 Nicolls Road , Stony Brook 11790 , New York , United States.
Chloé SavinoDepartment of Chemistry , Stony Brook University , 100 Nicolls Road , Stony Brook 11790 , New York , United States.
Shin Hye AhnDepartment of Chemistry , Stony Brook University , 100 Nicolls Road , Stony Brook 11790 , New York , United States.ORCID 0000-0003-4700-4861
Zhaoyong YangInstitute of Medicinal Biotechnology , Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing 100050 , People's Republic of China.
Steven G Van LanenDepartment of Pharmaceutical Sciences, College of Pharmacy , University of Kentucky , Lexington 40536 , Kentucky , United States.ORCID 0000-0003-1539-2732
Eszter BorosDepartment of Chemistry , Stony Brook University , 100 Nicolls Road , Stony Brook 11790 , New York , United States.ORCID 0000-0002-4186-6586
Stony Brook University · USChinese Academy of Medical Sciences & Peking Union Medical College · CNUniversity of Kentucky · US

Funding

Biosynthesis of nucleoside antibiotics targeting bacterial translocase IR01AI087849 · NIAID · UNIVERSITY OF KENTUCKY · PI VAN LANEN, STEVEN GARY · 2011 to 2020
$3.3M
Development of Zr-89 based immunoPET agents for idiopathic pulmonary fibrosisR00HL125728 · NHLBI · STATE UNIVERSITY NEW YORK STONY BROOK · PI BOROS, ESZTER · 2018 to 2020
$744k
NHLBI NIH HHS R00 HL125728NIAID NIH HHS R01 AI087849
6 · The paper itself

Abstract

Pathogenic bacteria scavenge ferric iron from the host for survival and proliferation using small-molecular chelators, siderophores. Here, we introduce and assess the gallium(III) complex of ciprofloxacin-functionalized desferrichrome (

Indexed as

Anti-Bacterial AgentsCiprofloxacinEscherichia coliGalliumGallium RadioisotopesIronRadiochemistrySiderophoresAnti-Bacterial AgentsCiprofloxacinGalliumGallium-67Gallium RadioisotopesIronSiderophores

Identifiers

PMID31580658
PMCPMC6943944
OpenAlexW2979236140

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.