ArticleBirth defects research2019
National population-based estimates for major birth defects, 2010-2014.
Article in Birth defects research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05711355 (A Randomized Trial of the Effects of Platelet-Rich Plasma on Postoperative Complications After Meningomyelocele Sac Repair), which is not on this map. Cited by 442 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Randomized Trial of the Effects of Platelet-Rich Plasma on Postoperative Complications After Meningomyelocele Sac Repair
Who cites it
442 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Communicating neurological prognosis in the prenatal period: a narrative review and practice guidelines.Pediatric research · 2025Guideline
- Maternal and perinatal outcomes of live births after uterus transplantation: A systematic review.Acta obstetricia et gynecologica Scandinavica · 2025Pooled it
- Opioid and benzodiazepine requirements in critically ill post-surgical children with down syndrome: a systematic review and meta-analysis.BMC pediatrics · 2024Pooled it
- Perinatal prevalence of birth defects in the Mainland of China, 2000-2021: a systematic review and meta-analysis.World journal of pediatrics : WJP · 2024Pooled it
- Nasal airway obstruction in patients with cleft lip nasal deformity: A systematic review.Journal of plastic, reconstructive & aesthetic surgery : JPRAS · 2024Pooled it
- The Association between Prenatal Nicotine Exposure and Offspring's Hearing Impairment.American journal of perinatology · 2024Trial
- Tablet Assessment of Cognition in Down Syndrome: Comparison of Researcher and Caregiver Administration.Journal of intellectual disability research : JIDR · 2026Article
- Growth in Children with a Cleft Lip and/or Palate in 8 US Hospitals: A Retrospective Cohort Study.JDR clinical and translational research · 2026Article
- Associations of Down Syndrome with Autism Spectrum Disorder and Attention Deficit/ Hyperactivity Disorder Among Children and Adolescents.Journal of autism and developmental disorders · 2026Article
- Parental anxiety in differences of sex development and hypospadias: a psychosocial characterization.Journal of the Endocrine Society · 2026Article
- The Implementation and Clinical Validation of a Whole-Genome Sequencing Non-Invasive Prenatal Test in a High-Complexity Clinical Laboratory: A Retrospective Analysis of 11,235 Pregnancies.Diagnostics (Basel, Switzerland) · 2026Article
- Association of Prior Balloon Atrial Septostomy with Mortality and Perioperative Outcomes in Neonates with D-Transposition of the Great Arteries Undergoing Arterial Switch Operation: A Systematic Review and Meta-analysis.Pediatric cardiology · 2026Article
- Congenital Anomaly Prevalence: A 10-Year Retrospective Study in a Tertiary Hospital in Turkey.Birth defects research · 2026Article
- Prevalence of spina bifida across the lifespan in the USA.Developmental medicine and child neurology · 2026Observational
- Primary Language Spoken at Home and Speech Outcomes Among Children With Cleft Palate.The Laryngoscope · 2026Article
- Preliminary evaluation of an adapted snack delay task for measuring inhibition in young children with Down syndrome.Research in developmental disabilities · 2026Article
- Effects of Smoothened Agonist Exposure on Murine Craniofacial Development.International dental journal · 2026Article
- The Relationship between Social Vulnerability Index, Area Deprivation Index, and Child Opportunity Index, and Treatment Course Characteristics in Infants with Surgically Intervenable Congenital Anomalies.American journal of perinatology · 2026Article
- Hyperactivation of the cGAS-STING pathway promotes liver inflammation in Down syndrome.Genes and immunity · 2026Article
- Congenital heart diseases involving congenitally diseased pulmonary valve phenotypes: Novel insights into the health care burden across the life course.JTCVS open · 2026Article
382 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
backgroundUsing the National Birth Defects Prevention Network (NBDPN) annual data report, U.S. national prevalence estimates for major birth defects are developed based on birth cohort 2010-2014.
methodsData from 39 U.S. population-based birth defects surveillance programs (16 active case-finding, 10 passive case-finding with case confirmation, and 13 passive without case confirmation) were used to calculate pooled prevalence estimates for major defects by case-finding approach. Fourteen active case-finding programs including at least live birth and stillbirth pregnancy outcomes monitoring approximately one million births annually were used to develop national prevalence estimates, adjusted for maternal race/ethnicity (for all conditions examined) and maternal age (trisomies and gastroschisis). These calculations used a similar methodology to the previous estimates to examine changes over time.
resultsThe adjusted national birth prevalence estimates per 10,000 live births ranged from 0.62 for interrupted aortic arch to 16.87 for clubfoot, and 19.93 for the 12 critical congenital heart defects combined. While the birth prevalence of most birth defects studied remained relatively stable over 15 years, an increasing prevalence was observed for gastroschisis and Down syndrome. Additionally, the prevalence for atrioventricular septal defect, tetralogy of Fallot, omphalocele, and trisomy 18 increased in this period compared to the previous periods. Active case-finding programs generally had higher prevalence rates for most defects examined, most notably for anencephaly, anophthalmia/microphthalmia, trisomy 13, and trisomy 18.
conclusionNational estimates of birth defects prevalence provide data for monitoring trends and understanding the impact of these conditions. Increasing prevalence rates observed for selected conditions warrant further examination.
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