Evidence map›Paper›PMID 31580477›Full record

ArticleEuropean journal of immunology2020

Opposing peripheral fates of tissue-restricted self antigen-specific conventional and regulatory CD4

Zimeng Zhang, Francois P Legoux, Spencer W Vaughan, James J Moon

Abstract read
In one paragraph

Article in European journal of immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Zimeng ZhangCenter for Immunology and Inflammatory Diseases, and Division of Pulmonary and Critical Care Medicine, Massachusetts General Hospital, and Harvard Medical School, Charlestown, MA, USA.
Francois P LegouxCenter for Immunology and Inflammatory Diseases, and Division of Pulmonary and Critical Care Medicine, Massachusetts General Hospital, and Harvard Medical School, Charlestown, MA, USA.
Spencer W VaughanCenter for Immunology and Inflammatory Diseases, and Division of Pulmonary and Critical Care Medicine, Massachusetts General Hospital, and Harvard Medical School, Charlestown, MA, USA.
James J MoonCenter for Immunology and Inflammatory Diseases, and Division of Pulmonary and Critical Care Medicine, Massachusetts General Hospital, and Harvard Medical School, Charlestown, MA, USA.ORCID 0000-0001-8246-931X

Funding

Pilot & Feasibility ProgramP30DK043351 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI RAYMOND T CHUNG · 1991 to 2026
$35.3M
Tetramer CoreU19AI095261 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI XAVIER, RAMNIK J · 2011 to 2015
$10.8M
Self Antigen Specific CD4 Positive T cellsR01AI107020 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI MOON, JAMES J · 2014 to 2018
$2.1M
CD4+ T cell Tolerance to Enteric Commensal BacteriaR21AI124143 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI MOON, JAMES J · 2017 to 2018
$448k
National Institute of Allergy and Infectious Diseases U19-AI095261NIAID NIH HHS R01 AI107020NIAID NIH HHS R21 AI124143NIAID NIH HHS U19 AI095261NIDDK NIH HHS P30 DK043351The Phillippe FoundationWilliam F. Milton Fund
6 · The paper itself

Abstract

The development of self antigen-specific T cells is influenced by how the self antigen is expressed. Here, we created a mouse in which a model self antigen is conditionally expressed in different tissue environments. Using peptide:MHCII tetramer-based cell enrichment methods, we examined the development of corresponding endogenous self antigen-specific CD4

Indexed as

AnimalsAutoantigensClonal AnergyMiceMice, Inbred C57BLMice, TransgenicSelf ToleranceT-Lymphocytes, RegulatoryAutoantigensClonal deletionImmune tolerancePeptide:MHC tetramerT cell selectionTCR

Identifiers

PMID31580477
PMCPMC8176781

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.