Evidence map›Paper›PMID 31580436›Full record

ArticleThe Journal of infectious diseases2020

Long-term Immunogenicity of Measles Vaccine: An Italian Retrospective Cohort Study.

Francesco Paolo Bianchi, Pasquale Stefanizzi, Sara De Nitto, Angela Maria Vittoria Larocca, Cinzia Germinario, Silvio Tafuri

Open access · hybridAbstract read
In one paragraph

Article in The Journal of infectious diseases, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
4.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 52 citations in OpenAlex.

  1. Article
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  5. A Case Series of Adult Measles from a Tertiary Care Hospital in North India.The American journal of tropical medicine and hygiene · 2025
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  13. Association between a low response to rubella vaccination and reduced anti-severe acute respiratory syndrome coronavirus 2 immune response after vaccination with BNT162b2: a cross-sectional study.Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases · 2023
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Francesco Paolo BianchiDepartment of Biomedical Science and Human Oncology, Aldo Moro University of Bari, Bari, Italy.
Pasquale StefanizziDepartment of Biomedical Science and Human Oncology, Aldo Moro University of Bari, Bari, Italy.
Sara De NittoDepartment of Biomedical Science and Human Oncology, Aldo Moro University of Bari, Bari, Italy.
Angela Maria Vittoria LaroccaHygiene Department, Bari Policlinico General Hospital, Bari, Italy.
Cinzia GerminarioDepartment of Biomedical Science and Human Oncology, Aldo Moro University of Bari, Bari, Italy.
Silvio TafuriDepartment of Biomedical Science and Human Oncology, Aldo Moro University of Bari, Bari, Italy.
University of Bari Aldo Moro · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLevels of antibodies induced by the measles virus-containing vaccine have been shown to decline over time, but there is no formal recommendation about testing immunized subjects (in particular, healthcare workers [HCWs]) to investigate the persistence of measles immunoglobulin G (IgG).

methodsThis study aims to evaluate the long-term immunogenicity of measles vaccine in a sample of medical students and residents of the University of Bari who attended the Hygiene Department for a biological risk assessment (April 2014-June 2018).

resultsTwo thousand immunized (2 doses of measles-mumps-rubella [MMR] vaccine) students and residents were tested; 305 of these (15%) did not show protective anti-measles IgG. This proportion was higher among subjects who received vaccination at ≤15 months (20%) than in those who received vaccination at 16-23 months (17%) and at ≥24 months (10%) (P < .0001). After an MMR vaccine booster dose, we noted a seroconversion of 74% of seronegative HCWs. The overall seroconversion rate after a second dose (booster) was 93%. No serious adverse events were noted after the booster doses.

conclusionsAn important proportion of subjects immunized for measles do not show a protective IgG titer in the 10 years after vaccination. Our management strategy seems consistent with the purpose of evidencing immunological memory.

Indexed as

Immunogenicity, VaccineVaccinationAdolescentAdultAntibodies, ViralFemaleHumansImmunization ScheduleImmunoglobulin GItalyMaleMeaslesMeasles-Mumps-Rubella VaccineMorbillivirusMumpsMumps virusAntibodies, ViralImmunoglobulin GMeasles-Mumps-Rubella Vaccinebooster doseduration of immunizationhealthcare workers

Identifiers

PMID31580436
PMCPMC7026886
OpenAlexW2977646350

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.