Evidence map›Paper›PMID 31580042›Full record

SynthesisJournal of psychiatry & neuroscience : JPN2020

Abnormalities of intrinsic regional brain activity in first-episode and chronic schizophrenia: a meta-analysis of resting-state functional MRI

Jiaying Gong, Junjing Wang, Xiaomei Luo, Guanmao Chen, Huiyuan Huang, Ruiwang Huang, Li Huang, Ying Wang

Open access · bronzeAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Journal of psychiatry & neuroscience : JPN, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 82 papers, 13 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
82citing papers in PubMed, 13 pooled it
5.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

82 citing papers in PubMed, 13 syntheses or guidelines pooled it, 125 citations in OpenAlex.

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  8. Distinct functional brain abnormalities in insomnia disorder and obstructive sleep apnea.European archives of psychiatry and clinical neuroscience · 2023
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22 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Jiaying GongFrom the Medical Imaging Center, First Affiliated Hospital of Jinan University, Guangzhou China (Gong, Luo, Chen, Huang, Wang); the Department of Radiology, Six Affiliated Hospital of Sun Yat-sen University, Guangzhou, China (Gong); the Department of Applied Psychology, Guangdong University of Foreign Studies, Guangzhou, China (Wang); the School of Psychology, Institute of Brain Research and Rehabilitation (IBRR), Center for the Study of Applied Psychology & MRI Center, Key Laboratory of Mental Health and Cognitive Science of Guangdong Province, South China Normal University, Guangzhou China (Huang, Huang).
Junjing WangFrom the Medical Imaging Center, First Affiliated Hospital of Jinan University, Guangzhou China (Gong, Luo, Chen, Huang, Wang); the Department of Radiology, Six Affiliated Hospital of Sun Yat-sen University, Guangzhou, China (Gong); the Department of Applied Psychology, Guangdong University of Foreign Studies, Guangzhou, China (Wang); the School of Psychology, Institute of Brain Research and Rehabilitation (IBRR), Center for the Study of Applied Psychology & MRI Center, Key Laboratory of Mental Health and Cognitive Science of Guangdong Province, South China Normal University, Guangzhou China (Huang, Huang).
Xiaomei LuoFrom the Medical Imaging Center, First Affiliated Hospital of Jinan University, Guangzhou China (Gong, Luo, Chen, Huang, Wang); the Department of Radiology, Six Affiliated Hospital of Sun Yat-sen University, Guangzhou, China (Gong); the Department of Applied Psychology, Guangdong University of Foreign Studies, Guangzhou, China (Wang); the School of Psychology, Institute of Brain Research and Rehabilitation (IBRR), Center for the Study of Applied Psychology & MRI Center, Key Laboratory of Mental Health and Cognitive Science of Guangdong Province, South China Normal University, Guangzhou China (Huang, Huang).
Guanmao ChenFrom the Medical Imaging Center, First Affiliated Hospital of Jinan University, Guangzhou China (Gong, Luo, Chen, Huang, Wang); the Department of Radiology, Six Affiliated Hospital of Sun Yat-sen University, Guangzhou, China (Gong); the Department of Applied Psychology, Guangdong University of Foreign Studies, Guangzhou, China (Wang); the School of Psychology, Institute of Brain Research and Rehabilitation (IBRR), Center for the Study of Applied Psychology & MRI Center, Key Laboratory of Mental Health and Cognitive Science of Guangdong Province, South China Normal University, Guangzhou China (Huang, Huang).
Huiyuan HuangFrom the Medical Imaging Center, First Affiliated Hospital of Jinan University, Guangzhou China (Gong, Luo, Chen, Huang, Wang); the Department of Radiology, Six Affiliated Hospital of Sun Yat-sen University, Guangzhou, China (Gong); the Department of Applied Psychology, Guangdong University of Foreign Studies, Guangzhou, China (Wang); the School of Psychology, Institute of Brain Research and Rehabilitation (IBRR), Center for the Study of Applied Psychology & MRI Center, Key Laboratory of Mental Health and Cognitive Science of Guangdong Province, South China Normal University, Guangzhou China (Huang, Huang).
Ruiwang HuangFrom the Medical Imaging Center, First Affiliated Hospital of Jinan University, Guangzhou China (Gong, Luo, Chen, Huang, Wang); the Department of Radiology, Six Affiliated Hospital of Sun Yat-sen University, Guangzhou, China (Gong); the Department of Applied Psychology, Guangdong University of Foreign Studies, Guangzhou, China (Wang); the School of Psychology, Institute of Brain Research and Rehabilitation (IBRR), Center for the Study of Applied Psychology & MRI Center, Key Laboratory of Mental Health and Cognitive Science of Guangdong Province, South China Normal University, Guangzhou China (Huang, Huang).
Li HuangFrom the Medical Imaging Center, First Affiliated Hospital of Jinan University, Guangzhou China (Gong, Luo, Chen, Huang, Wang); the Department of Radiology, Six Affiliated Hospital of Sun Yat-sen University, Guangzhou, China (Gong); the Department of Applied Psychology, Guangdong University of Foreign Studies, Guangzhou, China (Wang); the School of Psychology, Institute of Brain Research and Rehabilitation (IBRR), Center for the Study of Applied Psychology & MRI Center, Key Laboratory of Mental Health and Cognitive Science of Guangdong Province, South China Normal University, Guangzhou China (Huang, Huang).
Ying WangFrom the Medical Imaging Center, First Affiliated Hospital of Jinan University, Guangzhou China (Gong, Luo, Chen, Huang, Wang); the Department of Radiology, Six Affiliated Hospital of Sun Yat-sen University, Guangzhou, China (Gong); the Department of Applied Psychology, Guangdong University of Foreign Studies, Guangzhou, China (Wang); the School of Psychology, Institute of Brain Research and Rehabilitation (IBRR), Center for the Study of Applied Psychology & MRI Center, Key Laboratory of Mental Health and Cognitive Science of Guangdong Province, South China Normal University, Guangzhou China (Huang, Huang).
South China Normal University · CNFirst Affiliated Hospital of Jinan University · CNSixth Affiliated Hospital of Sun Yat-sen University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Resting-state functional MRI (fMRI) studies have provided much evidence for abnormal intrinsic brain activity in schizophrenia, but results have been inconsistent. Methods: We conducted a meta-analysis of whole-brain, resting-state fMRI studies that explored differences in amplitude of low-frequency fluctuation (ALFF) between people with schizophrenia (including first episode and chronic) and healthy controls. Results: A systematic literature search identified 24 studies comparing a total of 1249 people with schizophrenia and 1179 healthy controls. Overall, patients with schizophrenia displayed decreased ALFF in the bilateral postcentral gyrus, bilateral precuneus, left inferior parietal gyri and right occipital lobe, and increased ALFF in the right putamen, right inferior frontal gyrus, left inferior temporal gyrus and right anterior cingulate cortex. In the subgroup analysis, patients with first-episode schizophrenia demonstrated decreased ALFF in the bilateral inferior parietal gyri, right precuneus and left medial prefrontal cortex, and increased ALFF in the bilateral putamen and bilateral occipital gyrus. Patients with chronic schizophrenia showed decreased ALFF in the bilateral postcentral gyrus, left precuneus and right occipital gyrus, and increased ALFF in the bilateral inferior frontal gyri, bilateral superior frontal gyrus, left amygdala, left inferior temporal gyrus, right anterior cingulate cortex and left insula. Limitations: The small sample size of our subgroup analysis, predominantly Asian samples, processing steps and publication bias could have limited the accuracy of the results. Conclusion: Our comprehensive meta-analysis suggests that findings of aberrant regional intrinsic brain activity during the initial stages of schizophrenia, and much more widespread damage with the progression of disease, may contribute to our understanding of the progressive pathophysiology of schizophrenia.

Indexed as

Functional NeuroimagingMagnetic Resonance ImagingAdultCerebral CortexHumansMiddle AgedSchizophreniaYoung Adult

Identifiers

PMID31580042
PMCPMC6919918
OpenAlexW2982954585

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.