ArticleNature metabolism2019
Oncogenic Rag GTPase signaling enhances B cell activation and drives follicular lymphoma sensitive to pharmacological inhibition of mTOR.
Open access · greenAbstract read
In one paragraph
Article in Nature metabolism, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
2.8field-weighted citation impact, top 8% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 66 citations in OpenAlex.
- A guide to B cell metabolism.Nature reviews. Immunology · 2026Review
- Integrated multiomic profiling reveals 2 distinct splenic marginal zone lymphoma subgroups with prognostic relevance.Blood advances · 2026Article
- USF1-induced RPS6KB2 activation influences aggressive phenotype in B-cell non-Hodgkin lymphoma.Human cell · 2025Article
- Cross-talk between mitophagy pathways in pre-eclampsia and gestational diabetes mellitus: a systematic analysis of shared molecular mechanisms.European journal of medical research · 2025Article
- Transcriptional reprogramming in oral squamous cell carcinoma.Scientific reports · 2025Article
- Follicular lymphoma: contemporary clinical management with a focus on recent therapeutic advances.The Korean journal of internal medicine · 2025Review
- The nutrient-sensing Rag-GTPase complex in B cells controls humoral immunity via TFEB/TFE3-dependent mitochondrial fitness.Nature communications · 2024Article
- mTOR links nutrients, inflammaging and lifespan.Nature aging · 2024Article
- A mild increase in nutrient signaling to mTORC1 in mice leads to parenchymal damage, myeloid inflammation and shortened lifespan.Nature aging · 2024Article
- Ragopathies and the rising influence of RagGTPases on human diseases.Nature communications · 2024Review
- Micropeptides: potential treatment strategies for cancer.Cancer cell international · 2024Review
- Rag-GTPase-TFEB/TFE3 axis controls B cell mitochondrial fitness and humoral immunity independent of mTORC1.Research square · 2024Article
- The nutrient-sensing Rag-GTPase complex in B cells controls humoral immunity via TFEB/TFE3-dependent mitochondrial fitness.bioRxiv : the preprint server for biology · 2024Article
- The pathobiology of follicular lymphoma.Journal of clinical and experimental hematopathology : JCEH · 2023Article
- Raptor mediates the selective inhibitory effect of cardamonin on RRAGC-mutant B cell lymphoma.BMC complementary medicine and therapies · 2023Article
- Advances in the multi-omics landscape of follicular lymphoma.International journal of biological sciences · 2023Review
- Modeling the crosstalk between malignant B cells and their microenvironment in B-cell lymphomas: challenges and opportunities.Frontiers in immunology · 2023Review
- Biology of follicular lymphoma: insights and windows of clinical opportunity.Hematology. American Society of Hematology. Education Program · 2022Article
- GABA signaling enforces intestinal germinal center B cell differentiation.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Towards precision medicine in lymphoid malignancies.Journal of internal medicine · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
22 authors at 5 institutions in 4 countries.
Ana Ortega-MolinaMetabolism and Cell Signaling Laboratory. Spanish National Cancer Research Center (CNIO). Madrid, Spain.
Nerea Deleyto-SeldasMetabolism and Cell Signaling Laboratory. Spanish National Cancer Research Center (CNIO). Madrid, Spain.
Joaquim CarrerasTokai University, School of Medicine, Department of Pathology. Isehara, Kanagawa, Japan.
Alba SanzMetabolism and Cell Signaling Laboratory. Spanish National Cancer Research Center (CNIO). Madrid, Spain.
Cristina Lebrero-FernándezMetabolism and Cell Signaling Laboratory. Spanish National Cancer Research Center (CNIO). Madrid, Spain.
Camino MenéndezMetabolism and Cell Signaling Laboratory. Spanish National Cancer Research Center (CNIO). Madrid, Spain.
Andrew VandenbergMetabolism and Cell Signaling Laboratory. Spanish National Cancer Research Center (CNIO). Madrid, Spain.
Beatriz Fernández-RuizMetabolism and Cell Signaling Laboratory. Spanish National Cancer Research Center (CNIO). Madrid, Spain.
Leyre Marín-ArraizaMetabolism and Cell Signaling Laboratory. Spanish National Cancer Research Center (CNIO). Madrid, Spain.
Celia de la Calle ArreguiMetabolism and Cell Signaling Laboratory. Spanish National Cancer Research Center (CNIO). Madrid, Spain.
Ana Belén Plata-GómezMetabolism and Cell Signaling Laboratory. Spanish National Cancer Research Center (CNIO). Madrid, Spain.
Eduardo CaleirasHistopathology Unit. Spanish National Cancer Research Center (CNIO). Madrid, Spain.
Alba de MartinoHistopathology Unit. Spanish National Cancer Research Center (CNIO). Madrid, Spain.
Nuria Martínez-MartínCentro de Biología Molecular Severo Ochoa, Madrid, Spain.
Kevin TrouléBioinformatics Unit. Spanish National Cancer Research Center (CNIO). Madrid, Spain.
Elena Piñeiro-YáñezBioinformatics Unit. Spanish National Cancer Research Center (CNIO). Madrid, Spain.
Naoya NakamuraTokai University, School of Medicine, Department of Pathology. Isehara, Kanagawa, Japan.
Shamzah ArafCentre for Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London, London, UK.
Gabriel D VictoraLaboratory of Lymphocyte Dynamics, The Rockefeller University, New York, NY.
Jessica OkosunCentre for Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London, London, UK.
Jude FitzgibbonCentre for Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London, London, UK.
Alejo EfeyanMetabolism and Cell Signaling Laboratory. Spanish National Cancer Research Center (CNIO). Madrid, Spain.
Spanish National Cancer Research Centre · ESQueen Mary University of London · GBTokai University · JPCentro de Biología Molecular Severo Ochoa · ESRockefeller University · US
Funding
Regulation of the mTOR Pathway By NutrientsR01CA103866 · NCI · WHITEHEAD INSTITUTE FOR BIOMEDICAL RES · PI WEISSMAN, JONATHAN S. · 2004 to 2021
$7.0MCell Growth Signaling in Cancer DevelopmentR01CA129105 · NCI · WHITEHEAD INSTITUTE FOR BIOMEDICAL RES · PI WEISSMAN, JONATHAN S. · 2008 to 2021
$5.9MNovel Components of the mTORC1 and mTORC2 PathwaysR37AI047389 · NIAID · WHITEHEAD INSTITUTE FOR BIOMEDICAL RES · PI SABATINI, DAVID M. · 2010 to 2019
$4.8MCancer Research UK 15968Cancer Research UK A15968Cancer Research UK A22742European Research Council 638891NCI NIH HHS R01 CA103866NCI NIH HHS R01 CA129105NIAID NIH HHS R37 AI047389
Abstract
The humoral immune response demands that B cells undergo a sudden anabolic shift and high cellular nutrient levels which are required to sustain the subsequent proliferative burst. Follicular lymphoma (FL) originates from B cells that have participated in the humoral response, and 15% of FL samples harbor point, activating mutations in
Indexed as
Lymphocyte ActivationSignal TransductionAnimalsGTP PhosphohydrolasesHumansLymphoma, FollicularMiceMice, TransgenicTOR Serine-Threonine KinasesGTP PhosphohydrolasesMTOR protein, humanTOR Serine-Threonine KinasesapoptosisB cell lymphomaB lymphocytescell growthgerminal centermTORnutrient signalingrapamycinRRAGCT follicular helper
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.