ReviewPain reports
Neuroimaging-based pain biomarkers: definitions, clinical and research applications, and evaluation frameworks to achieve personalized pain medicine.
Review in Pain reports. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
44 citing papers in PubMed, 70 citations in OpenAlex.
- Impact of psycho-educational interventions on patients undergoing Coronary Artery Bypass Grafting Surgery.Journal of cardiothoracic surgery · 2025Trial
- Task-evoked network connectivity and pain regulation success in chronic low back pain.Neuroimage. Reports · 2026Article
- Knowledge Graph and Large Language Model-Based Analysis of fMRI Brain Functional Neuroimaging Research.Bioengineering (Basel, Switzerland) · 2026Article
- Intensity-dependent topographical expansion of sensory representations.bioRxiv : the preprint server for biology · 2026Article
- Targeting protein kinase C signaling cascades in alzheimer's disease: emerging neuroprotective roles of aurothioglucose.Inflammopharmacology · 2026Review
- Structural and Functional Brain Alterations in Postherpetic Neuralgia: A Systematic Review and Voxel-Wise Coordinate-Based Meta-Analysis via the SDM-PSI Method.Journal of pain research · 2026Review
- Rethinking Pain Assessment: Subjective Scales, Biomarkers, and Multimodal Integration.Journal of pain research · 2026Review
- Objective Measurement of Musculoskeletal Pain: A Comprehensive Review.Diagnostics (Basel, Switzerland) · 2025Review
- Sex differences in the transition to chronic pain.The Journal of clinical investigation · 2025Review
- Innovations in acute and chronic pain biomarkers: enhancing diagnosis and personalized therapy.Regional anesthesia and pain medicine · 2025Review
- Review
- Advances and challenges in neuroimaging-based pain biomarkers.Cell reports. Medicine · 2024Review
- Interindividual differences in pain can be explained by fMRI, sociodemographic, and psychological factors.Nature communications · 2024Article
- Article
- Pain mechanisms in the transgender individual: a review.Frontiers in pain research (Lausanne, Switzerland) · 2024Review
- Pain and the Non-Pharmacological Management of Pain in People with Parkinson's Disease.Journal of Parkinson's disease · 2024Review
- Recent developments and future avenues for human corticospinal neuroimaging.Frontiers in human neuroscience · 2024Review
- Artificial Intelligence and Pain Medicine: An Introduction.Journal of pain research · 2024Review
- Microstructural Changes in the Spinothalamic Tract of CPSS Patients: Preliminary Results from a Single-Center Diffusion-Weighted Magnetic Resonance Imaging Study.Brain sciences · 2023Article
- Translation and validation of urdu version short form-mcgill pain questionnaire-2.BMC sports science, medicine & rehabilitation · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 1 country.
Funding
Abstract
One of the key ambitions of neuroimaging-based pain biomarker research is to augment patient and clinician reporting of clinically relevant phenomena with neural measures for prediction, prognosis, and detection of pain. Despite years of productive research on the neuroimaging of pain, such applications have seen little advancement. However, recent developments in identifying brain-based biomarkers of pain through advances in technology and multivariate pattern analysis provide some optimism. Here, we (1) define and review the different types of potential neuroimaging-based biomarkers, their clinical and research applications, and their limitations and (2) describe frameworks for evaluation of pain biomarkers used in other fields (eg, genetics, cancer, cardiovascular disease, immune system disorders, and rare diseases) to achieve broad clinical and research utility and minimize the risks of misapplication of this emerging technology. To conclude, we discuss future directions for neuroimaging-based biomarker research to achieve the goal of personalized pain medicine.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.