ArticlePain reports
Neuroimaging of pain in animal models: a review of recent literature.
Article in Pain reports. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed.
- Post-traumatic osteoarthritis in aged rodents is associated with brain changes that correlate with joint remodeling.The journal of pain · 2026Article
- The causal role of brain circuits in osteoarthritis pain.Nature reviews. Rheumatology · 2025Review
- At the Intersection of Pain and Sleep: a Roadmap for Preclinical Pain Research.Frontiers in pain research (Lausanne, Switzerland) · 2025Review
- Advancing Pain Understanding and Drug Discovery: Insights from Preclinical Models and Recent Research Findings.Pharmaceuticals (Basel, Switzerland) · 2024Review
- Advances and challenges in neuroimaging-based pain biomarkers.Cell reports. Medicine · 2024Review
- Enkephalins and Pain Modulation: Mechanisms of Action and Therapeutic Perspectives.Biomolecules · 2024Review
- Centralizing the Knowledge and Interpretation of Pain in Chemotherapy-Induced Peripheral Neuropathy: A Paradigm Shift towards Brain-Centric Approaches.Brain sciences · 2024Review
- Review
- Machines, mathematics, and modules: the potential to provide real-time metrics for pain under anesthesia.Neurophotonics · 2024Article
- Comparison of Trihalomethane exposure assessment metrics in epidemiologic analyses of reproductive and developmental outcomes.Journal of exposure science & environmental epidemiology · 2024Article
- Potential sex differences in activation of pain-related brain regions in nonhuman primates with a unilateral spinal nerve ligation.Neural regeneration research · 2023Article
- Longitudinal Change in Brain Functional Connectivity with Herpes Zoster Patients: Neuroimaging Case Series.Medicina (Kaunas, Lithuania) · 2023Article
- Changes in brain structure and related functional connectivity during menstruation in women with primary dysmenorrhea.Quantitative imaging in medicine and surgery · 2023Article
- Altered brain activities in mesocorticolimbic pathway in primary dysmenorrhea patients of long-term menstrual pain.Frontiers in neuroscience · 2023Article
- Development of a PET radioligand for α2δ-1 subunit of calcium channels for imaging neuropathic pain.European journal of medicinal chemistry · 2022Article
- The Roles of Imaging Biomarkers in the Management of Chronic Neuropathic Pain.International journal of molecular sciences · 2022Review
- Kinds of Harm: Animal Law Language from a Scientific Perspective.Animals : an open access journal from MDPI · 2022Article
- Preventing pediatric chronic postsurgical pain: Time for increased rigor.Canadian journal of pain = Revue canadienne de la douleur · 2022Review
- Mouse Anesthesia: The Art and Science.ILAR journal · 2021Review
- Nociceptive pain and anxiety in equines: Physiological and behavioral alterations.Veterinary world · 2021Review
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neuroimaging of pain in animals allows us to better understand mechanisms of pain processing and modulation. In this review, we discuss recently published brain imaging studies in rats, mice, and monkeys, including functional magnetic resonance imaging (MRI), manganese-enhanced MRI, positron emission tomography, and electroencephalography. We provide an overview of innovations and limitations in neuroimaging techniques, as well as results of functional brain imaging studies of pain from January 1, 2016, to October 10, 2018. We then discuss how future investigations can address some bias and gaps in the field. Despite the limitations of neuroimaging techniques, the 28 studies reinforced that transition from acute to chronic pain entails considerable changes in brain function. Brain activations in acute pain were in areas more related to the sensory aspect of noxious stimulation, including primary somatosensory cortex, insula, cingulate cortex, thalamus, retrosplenial cortex, and periaqueductal gray. Pharmacological and nonpharmacological treatments modulated these brain regions in several pain models. On the other hand, in chronic pain models, brain activity was observed in regions commonly associated with emotion and motivation, including prefrontal cortex, anterior cingulate cortex, hippocampus, amygdala, basal ganglia, and nucleus accumbens. Neuroimaging of pain in animals holds great promise for advancing our knowledge of brain function and allowing us to expand human subject research. Additional research is needed to address effects of anesthesia, analysis approaches, sex bias and omission, and potential effects of development and aging.
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