Evidence map›Paper›PMID 31579840›Full record

ArticleJournal of clinical and translational research2019

Circulating extracellular RNAs, myocardial remodeling, and heart failure in patients with acute coronary syndrome.

Khanh-Van Tran, Kahraman Tanriverdi, Gerard P Aurigemma, Darleen Lessard, Mayank Sardana, Matthew Parker, Amir Shaikh, Matthew Gottbrecht, Zachary Milstone, Selim Tanriverdi and 5 more

Open access · diamondAbstract read
PubMed Full text at PMC
In one paragraph

Article in Journal of clinical and translational research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.

  1. Pooled it
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  7. Review
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  10. MicroRNAs: Midfielders of Cardiac Health, Disease and Treatment.International journal of molecular sciences · 2023
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Khanh-Van TranDepartment of Medicine, Health Sciences University of Massachusetts Medical School, Worcester, MA, USA.
Kahraman TanriverdiDepartment of Medicine, Health Sciences University of Massachusetts Medical School, Worcester, MA, USA.
Gerard P AurigemmaDepartment of Medicine, Health Sciences University of Massachusetts Medical School, Worcester, MA, USA.
Darleen LessardPopulation and Quantitative Health Sciences University of Massachusetts Medical School, Worcester, MA, USA.
Mayank SardanaDepartment of Medicine, Health Sciences University of Massachusetts Medical School, Worcester, MA, USA.
Matthew ParkerDepartment of Medicine, Health Sciences University of Massachusetts Medical School, Worcester, MA, USA.
Amir ShaikhDepartment of Medicine, Health Sciences University of Massachusetts Medical School, Worcester, MA, USA.
Matthew GottbrechtDepartment of Medicine, Health Sciences University of Massachusetts Medical School, Worcester, MA, USA.
Zachary MilstoneDepartment of Medicine, Health Sciences University of Massachusetts Medical School, Worcester, MA, USA.
Selim TanriverdiDepartment of Medicine, Health Sciences University of Massachusetts Medical School, Worcester, MA, USA.
Olga VitsevaDepartment of Medicine, Health Sciences University of Massachusetts Medical School, Worcester, MA, USA.
John F KeaneyDepartment of Medicine, Health Sciences University of Massachusetts Medical School, Worcester, MA, USA.
Catarina I KiefePopulation and Quantitative Health Sciences University of Massachusetts Medical School, Worcester, MA, USA.
David D McManusDepartment of Medicine, Health Sciences University of Massachusetts Medical School, Worcester, MA, USA.
Jane E FreedmanDepartment of Medicine, Health Sciences University of Massachusetts Medical School, Worcester, MA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundGiven high on-treatment mortality in heart failure (HF), identifying molecular pathways that underlie adverse cardiac remodeling may offer novel biomarkers and therapeutic avenues. Circulating extracellular RNAs (ex-RNAs) regulate important biological processes and are emerging as biomarkers of disease, but less is known about their role in the acute setting, particularly in the setting of HF.

methodsWe examined the ex-RNA profiles of 296 acute coronary syndrome (ACS) survivors enrolled in the Transitions, Risks, and Actions in Coronary Events Center for Outcomes Research and Education Cohort. We measured 374 ex-RNAs selected

resultsWe identified 44 ex-RNAs associated with at least one echocardiographic phenotype associated with HF. Of these 44 exRNAs, miR-29-3p, miR-584-5p, and miR-1247-5p were also associated with prevalent HF. The three microRNAs were implicated in the regulation p53 and transforming growth factor-β signaling pathways and predicted to be involved in cardiac fibrosis and cell death; miRNA predicted targets were enriched in gene ontology categories including several involving the extracellular matrix and cellular differentiation.

conclusionsAmong ACS survivors, we observed that miR-29-3p, miR-584-5p, and miR-1247-5p were associated with both echocardiographic markers of cardiac remodeling and prevalent HF. RELEVANCE FOR PATIENTS: miR-29c-3p, miR-584-5p, and miR-1247-5p were associated with echocardiographic phenotypes and prevalent HF and are potential biomarkers for adverse cardiac remodeling in HF.

Indexed as

BiomarkersCardiac remodellingEchocardiographic phenotypesExtracellular RNAsHeart failure

Identifiers

PMID31579840
PMCPMC6765153
OpenAlexW2962418816

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.