ArticleScience advances2019
IgM in human immunity to
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Article in Science advances, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 89 papers.
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89citing papers in PubMed
20.9field-weighted citation impact, top 1% of its field
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
89 citing papers in PubMed, 142 citations in OpenAlex.
- R21/Matrix-M malaria vaccine drives diverse immune responses in pre-exposed adults: insights from a phase IIb controlled human malaria infection trial.Frontiers in immunology · 2025Trial
- Antibodies Produced in Response to a Live-Attenuated Dengue Vaccine Are Functional in Activating the Complement System.The Journal of infectious diseases · 2023Trial
- Safety, infectivity and immunogenicity of a genetically attenuated blood-stage malaria vaccine.BMC medicine · 2021Trial
- Multifunctional Antibodies Are Induced by the RTS,S Malaria Vaccine and Associated With Protection in a Phase 1/2a Trial.The Journal of infectious diseases · 2021Trial
- Antiphosphatidylserine Immunoglobulin M and Immunoglobulin G Antibodies Are Higher in Vivax Than Falciparum Malaria, and Associated With Early Anemia in Both Species.The Journal of infectious diseases · 2019Trial
- An mRNA-lipid nanoparticle vaccine targeting theMolecular therapy. Nucleic acids · 2026Article
- Development of an Experimental Human Blood-Stage Model for Studying Plasmodium knowlesi.The Journal of infectious diseases · 2026Article
- Elevated Plasmodium falciparum sexual conversion in HbAC and HbAS red blood cells in naturally infected malaria patients.PLoS pathogens · 2026Article
- Malaria serology for surveillance, insights into immunity, and vaccine development.Infection and immunity · 2026Review
- Antibody Responses to the ConservedPathogens (Basel, Switzerland) · 2026Article
- Vaccine-induced mouse antibodies targeting Plasmodium falciparum PfVFT antigen inhibit blood stages through multiple mechanisms.NPJ vaccines · 2026Article
- Module-level recombination drives DBLMSP polymorphism and functional conservation in Plasmodium falciparum.Parasite (Paris, France) · 2026Article
- Targeting a malaria merozoite surface protein with mRNA vaccine generates multifunctional antibodies.Frontiers in immunology · 2026Article
- IgG and IgM responses to PfEMP1 domains associated with semi-immunity to clinical malaria in Burkinabe children under five.Frontiers in immunology · 2026Article
- Naturally acquired antibodies toFrontiers in immunology · 2026Article
- VAR2CSA-specific IgG and IgM antibodies are markers of exposure and protection against adverse malaria pregnancy outcomes.Malaria journal · 2025Article
- Immunoinformatics-Based Multi-Epitope Vaccine Design AgainstHealth science reports · 2025Article
- Circulating Immune Complexes and Glucose-6-Phosphate Dehydrogenase Deficiency Predict Recurrent Blackwater Fever in Ugandan Children With Severe Malaria.The Journal of infectious diseases · 2025Article
- Deposition of complement regulators on the surface of Plasmodium falciparum merozoites depends on the immune status of the host.PLoS pathogens · 2025Article
- Antibody correlates of risk of clinical malaria in an area of low and unstable malaria transmission in western Kenya.Malaria journal · 2025Article
29 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
28 authors at 9 institutions in 6 countries.
M J BoyleBurnet Institute for Medical Research and Public Health, Melbourne, Victoria, Australia.ORCID 0000-0002-0268-232X
J A ChanBurnet Institute for Medical Research and Public Health, Melbourne, Victoria, Australia.ORCID 0000-0003-0708-8263
I HandayuniGlobal and Tropical Health Division, Menzies School of Health Research, Darwin, Northern Territory, Australia.
L ReilingBurnet Institute for Medical Research and Public Health, Melbourne, Victoria, Australia.
G FengBurnet Institute for Medical Research and Public Health, Melbourne, Victoria, Australia.
A HiltonBurnet Institute for Medical Research and Public Health, Melbourne, Victoria, Australia.ORCID 0000-0001-8739-1830
L KurtovicBurnet Institute for Medical Research and Public Health, Melbourne, Victoria, Australia.ORCID 0000-0001-8594-0031
D OyongGlobal and Tropical Health Division, Menzies School of Health Research, Darwin, Northern Territory, Australia.
K A PieraGlobal and Tropical Health Division, Menzies School of Health Research, Darwin, Northern Territory, Australia.ORCID 0000-0002-7414-9604
B E BarberGlobal and Tropical Health Division, Menzies School of Health Research, Darwin, Northern Territory, Australia.ORCID 0000-0003-1066-7960
T WilliamInfectious Diseases Society Sabah-Menzies School of Health Research Clinical Research Unit, Queen Elizabeth Hospital, Kota Kinabalu, Sabah, Malaysia.ORCID 0000-0002-2195-6736
D P EisenAustralian Institute of Tropical Health and Medicine, James Cook University, Cairns, Queensland, Australia.
G MinigoGlobal and Tropical Health Division, Menzies School of Health Research, Darwin, Northern Territory, Australia.ORCID 0000-0001-5158-7700
C LangerBurnet Institute for Medical Research and Public Health, Melbourne, Victoria, Australia.
D R DrewBurnet Institute for Medical Research and Public Health, Melbourne, Victoria, Australia.
F de Labastida RiveraQIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.ORCID 0000-0001-5241-2339
F H AmanteQIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
T N WilliamsKenya Medical Research Institute (KEMRI), Centre for Geographic Medicine, Coast, KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya.
S KinyanjuiKenya Medical Research Institute (KEMRI), Centre for Geographic Medicine, Coast, KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya.ORCID 0000-0002-3910-0450
K MarshKenya Medical Research Institute (KEMRI), Centre for Geographic Medicine, Coast, KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya.ORCID 0000-0001-8377-5466
D L DoolanAustralian Institute of Tropical Health and Medicine, James Cook University, Cairns, Queensland, Australia.
C EngwerdaQIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.ORCID 0000-0003-2813-4804
F J I FowkesBurnet Institute for Medical Research and Public Health, Melbourne, Victoria, Australia.
M J GriggGlobal and Tropical Health Division, Menzies School of Health Research, Darwin, Northern Territory, Australia.ORCID 0000-0001-9914-8352
I MuellerWalter and Eliza Hall Institute, Melbourne, Victoria, Australia.
J S McCarthyQIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.ORCID 0000-0001-6596-9718
N M AnsteyGlobal and Tropical Health Division, Menzies School of Health Research, Darwin, Northern Territory, Australia.
J G BeesonBurnet Institute for Medical Research and Public Health, Melbourne, Victoria, Australia.ORCID 0000-0002-1018-7898
Burnet Institute · AUQIMR Berghofer Medical Research Institute · AUCharles Darwin University · AUKenya Medical Research Institute · KEMenzies School of Health Research · AUAustralian Institute of Tropical Health and Medicine · AUGleneagles Hospital · SGInstitut Pasteur · FRThe University of Queensland · AU
Funding
Wellcome Trust 202800/Z/16/Z
Abstract
Most studies on human immunity to malaria have focused on the roles of immunoglobulin G (IgG), whereas the roles of IgM remain undefined. Analyzing multiple human cohorts to assess the dynamics of malaria-specific IgM during experimentally induced and naturally acquired malaria, we identified IgM activity against blood-stage parasites. We found that merozoite-specific IgM appears rapidly in
Indexed as
ImmunityAdolescentAdultAntibodies, ProtozoanAntibody FormationAntibody SpecificityAntigens, ProtozoanFemaleHost-Parasite InteractionsHumansImmunoglobulin GImmunoglobulin MMalaria, FalciparumMaleMiddle AgedPlasmodium falciparumAntibodies, ProtozoanAntigens, ProtozoanImmunoglobulin GImmunoglobulin M
Identifiers
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.