Evidence map›Paper›PMID 31579820›Full record

ArticleScience advances2019

Delivery of RIPK4 small interfering RNA for bladder cancer therapy using natural halloysite nanotubes.

Jianye Liu, Yi Zhang, Qinghai Zeng, Hongliang Zeng, Xiaoming Liu, Pei Wu, Hongyi Xie, Leye He, Zhi Long, Xiaoyong Lu and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 64 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 1 country.

Jianye LiuDepartment of Urology, The Third Xiangya Hospital of Central South University, Changsha 410013, China.ORCID 0000-0002-7953-3672
Yi ZhangSchool of Minerals Processing and Bioengineering, Central South University, Changsha 410083, China.ORCID 0000-0003-0391-7159
Qinghai ZengDepartment of Dermatology, The Third Xiangya Hospital of Central South University, Changsha 410013, China.ORCID 0000-0002-3489-2057
Hongliang ZengHunan Key Laboratory of Pharmacodynamics and Safety Evaluation of New Drugs, Changsha 410331, China.
Xiaoming LiuDepartment of Digestive, The Third Xiangya Hospital of Central South University, Changsha 410013, China.
Pei WuDepartment of Operation Center, The Second Xiangya Hospital of Central South University, Changsha 410011, China.
Hongyi XieSchool of Minerals Processing and Bioengineering, Central South University, Changsha 410083, China.
Leye HeDepartment of Urology, The Third Xiangya Hospital of Central South University, Changsha 410013, China.
Zhi LongDepartment of Urology, The Third Xiangya Hospital of Central South University, Changsha 410013, China.
Xiaoyong LuDepartment of Urology, Hunan Aerospace Hospital, Changsha 410205, China.
Mengqing XiaoDepartment of Onology, The Third Xiangya Hospital of Central South University, Changsha 410013, China.
Yuxing ZhuDepartment of Onology, The Third Xiangya Hospital of Central South University, Changsha 410013, China.
Hao BoInstitute of Reproductive and Stem Cell Engineering, Central South University, Changsha 410008, China.
Ke CaoDepartment of Onology, The Third Xiangya Hospital of Central South University, Changsha 410013, China.ORCID 0000-0001-5392-2306
Central South University · CNHunan Mawangdui Hospital · CNHunan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

RNA interference (RNAi) technology can specifically silence the expression of a target gene and has emerged as a promising therapeutic method to treat cancer. In the present study, we showed that natural halloysite nanotube (HNT)-assisted delivery of an active small interfering RNA (siRNA) targeting receptor-interacting protein kinase 4 (

Indexed as

Drug CarriersGene Transfer TechniquesNanotubesAnimalsApoptosisCell Line, TumorCell ProliferationChemistry Techniques, SyntheticDisease Models, AnimalGenetic TherapyHumansLysosomesMiceModels, BiologicalNF-kappaB-Inducing KinaseProtein Serine-Threonine KinasesDrug CarriersNF-kappaB-Inducing KinaseProtein Serine-Threonine KinasesRIPK4 protein, humanRNA, Small Interfering

Identifiers

PMID31579820
PMCPMC6760933
OpenAlexW2975329111

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.