Evidence map›Paper›PMID 31579758›Full record

ArticleInnovative surgical sciences2017

Neoadjuvant peptide receptor radionuclide therapy and modified multivisceral transplantation for an advanced small intestinal neuroendocrine neoplasm: an updated case report.

Ashley K Clift, Henk Giele, Srikanth Reddy, Rubens Macedo, Adil Al-Nahhas, Harpreet S Wasan, Gabriel E Gondolesi, Rodrigo M Vianna, Peter Friend, Anil Vaidya and 1 more

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Innovative surgical sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 2 countries.

Ashley K CliftDepartment of Surgery and Cancer, Imperial College London, London, UK.
Henk GieleDepartment of Plastic and Reconstructive Surgery, Oxford University NHS Trust, Oxford, UK.
Srikanth ReddyOxford Transplant Centre, Oxford University NHS Trust, Oxford, UK.
Rubens MacedoOxford Transplant Centre, Oxford University NHS Trust, Oxford, UK.
Adil Al-NahhasDepartment of Nuclear Medicine, Imperial College London, London, UK.
Harpreet S WasanDepartment of Surgery and Cancer, Imperial College London, London, UK.
Gabriel E GondolesiInstituto de Trasplante Multiorgano, Fundacion Favaloro, Buenos Aires, Argentina.
Rodrigo M ViannaMiami Transplant Institute, University of Miami/Jackson Memorial Hospital, Miami, FL, USA.
Peter FriendOxford Transplant Centre, Oxford University NHS Trust, Oxford, UK.
Anil VaidyaDepartment of Plastic and Reconstructive Surgery, Oxford University NHS Trust, Oxford, UK.
Andrea FrillingDepartment of Surgery and Cancer, Imperial College London, Hammersmith Hospital, Du Cane Road, London, W12 0HS, UK,.
Imperial College London · GBUniversity of Oxford · GBOxford University Hospitals NHS Trust · GBHammersmith Hospital · GBMiami Transplant Institute · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Small intestinal neuroendocrine neoplasms (SI-NEN) frequently metastasise to regional lymph nodes, and surgery is the mainstay of therapy for such patients. However, despite the possible use of advanced surgical techniques, the resection of both primary and locoregional diseases is not always attainable. Intestinal and multivisceral transplantation has been performed in a small number of patients with conventionally nonresectable, slow-growing tumours threatening the mesenteric root but has remained controversial. The use of donor skin in "sentinel flaps" in transplantation theoretically offers advantages in tailoring immunosuppression and monitoring for rejection. We represent (with extended follow-up) the first case of a patient with inoperable extensive mesenteric metastases from SI-NEN, who underwent neoadjuvant peptide receptor radionuclide therapy before a modified multivisceral transplant with a concomitant vascularised sentinel forearm flap. At 48 months after transplantation, our patient remained at full physical activity with no evidence of disease recurrence on either tumour biochemistry or radiological imaging.

Indexed as

multivisceralneoplasmneuroendocrinesentinel flaptransplantation

Identifiers

PMID31579758
PMCPMC6754026
OpenAlexW2748506911

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.