ReviewInnovative surgical sciences2017
The changing paradigm of resection margins in sarcoma resection.
Review in Innovative surgical sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04752137 (Evaluation of Intraoperative Tumor Margin Identification With Fluorescent Dye Imaging), which is not on this map. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Evaluation of Intraoperative Tumor Margin Identification With Fluorescent Dye Imaging
Who cites it
11 citing papers in PubMed.
- Indications and Outcomes of Nerve Reconstructions After Resection of Extremity Tumors: A Systematic Review.Plastic surgery (Oakville, Ont.) · 2026Review
- Effect of Surgical Margins on Local Recurrence Patterns of Myxofibrosarcomas: A Retrospective Cohort Study From the Stockholm Sarcoma Centre.Journal of surgical oncology · 2025Article
- Clinical and Surgical Outcome After Oncovascular Surgery of Soft Tissue and Osteogenic Sarcomas of the Limbs.Cancer reports (Hoboken, N.J.) · 2025Article
- Radiation-associated angiosarcoma of the breast: radical resection technique of the entire radiation field.Therapeutic advances in medical oncology · 2025Article
- Article
- Risk Stratification with Sarculator and MSKCC in Patients with Primary and Secondary Angiosarcoma.Life (Basel, Switzerland) · 2024Article
- Current understanding of angiosarcoma: disease biology and evolving treatment.Archives of craniofacial surgery · 2023Article
- Postoperative complications and oncologic outcomes after multimodal therapy of localized high risk soft tissue sarcoma.Radiation oncology (London, England) · 2022Article
- Evaluation of the efficacy of CT-guided 3D template-assistedScientific reports · 2022Article
- [Soft tissue sarcomas: limb salvage using reconstructive plastic surgery techniques].Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen · 2019Review
- Effect of Favorable Pathologic Response After Neoadjuvant Radiation Therapy Alone in Soft-tissue Sarcoma.Advances in radiation oncologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Soft tissue sarcomas (STS) are a heterogeneous group of rare mesenchymal tumors that account for approximately 1% of all adult malignancies. They can arise throughout the body due to their mesenchymal origin, although 60% of all STS occur in the extremities. Locally advanced STS can lead to significant functional morbidity and tend to local recurrences despite surgical resection. About 30% of all STS patients develop distant metastases with a median overall survival of less than 15 months. The treatment of choice in patients with localized disease is still surgical resection with negative margins. However, there has been a paradigm shift in the last few decades. Large retrospective analyses could not establish a strong association between radical resections and improved local control or survival. Previous radical concepts in STS surgery have been gradually replaced by more moderate approaches with function- and limb-sparing resections combined with radiotherapy. Here, the margin status appears to be of prognostic significance. However, several large retrospective analyses have presented inconsistent results, questioning the independent prognostic impact of surgical margins. This article reviews the literature critically, focusing on the changing role of surgical margins in STS surgery.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.