Evidence map›Paper›PMID 31579656›Full record

ArticlePublic health action2019

Tuberculosis treatment unmasking leprosy: management of drug-resistant tuberculosis and leprosy co-infection.

G Kama, G K L Huang, M Taune, R Arura, L Morris, B Kombuk, A Marome, D P O'Brien

Abstract read
In one paragraph

Article in Public health action, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

G KamaDaru General Hospital, Daru, Western Province, Papua New Guinea (PNG).
G K L HuangBurnet Institute, Melbourne, Victoria, Australia.
M TauneDaru General Hospital, Daru, Western Province, Papua New Guinea (PNG).
R AruraDaru General Hospital, Daru, Western Province, Papua New Guinea (PNG).
L MorrisWestern Province Health Department, Daru, PNG.
B KombukDaru General Hospital, Daru, Western Province, Papua New Guinea (PNG).
A MaromeNational Department of Health, Public Health Division, Port Moresby, PNG.
D P O'BrienBurnet Institute, Melbourne, Victoria, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Co-infection with tuberculosis (TB) and leprosy is thought to occur infrequently, but has been reported in settings highly endemic for both infectious diseases. We report for the first time a case where treatment for multidrug-resistant TB (MDR-TB) led to the 'unmasking' of clinically silent leprosy through the precipitation of a type-1 immunological reaction. Current treatment regimens for MDR-TB may contain a number of drugs, such as levo-floxacin and clofazimine, which also have activity against M. leprae. A treatment regimen containing drugs active against both mycobacterial species may be used to achieve cure. Individual considerations on drug-drug interactions, potential additive toxicities and other comorbidities should be taken into account.

Indexed as

co-infectionimmunologicalleprosyparadoxicalTB

Identifiers

PMID31579656
PMCPMC6735462

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.