ArticleNeuro-oncology practice2016
The era of stereotactic body radiotherapy for spinal metastases and the multidisciplinary management of complex cases.
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Article in Neuro-oncology practice, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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9citing papers in PubMed
3.0field-weighted citation impact, top 9% of its field
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 28 citations in OpenAlex.
- The tumor core boost study: A feasibility study of radical dose escalation to the central part of large tumors with an integrated boost in the palliative treatment setting.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2023Trial
- [Expert Consensus on the Diagnosis and Treatment of Bone Metastasis in Lung Cancer (2019 Version)].Zhongguo fei ai za zhi = Chinese journal of lung cancer · 2019Article
- Clinical outcomes of multileaf collimator-based CyberKnife for spine stereotactic body radiation therapy.The British journal of radiology · 2017Article
- Modern approaches to the management of metastatic epidural spinal cord compression.CNS oncology · 2017Article
- Spinal Cord Delineation Based on Computed Tomography Myelogram Versus T2 Magnetic Resonance Imaging in Spinal Stereotactic Body Radiation Therapy.Advances in radiation oncologyArticle
- The role of multidisciplinary team meetings in the management of spinal tumors.Journal of craniovertebral junction & spineReview
- Characteristics and Predictors of Radiographic Local Failure in Patients With Spinal Metastases Treated With Palliative Conventional Radiation Therapy.Advances in radiation oncologyArticle
- Time Dependence of Intra-fractional Motion in Spinal Stereotactic Body Radiotherapy.In vivo (Athens, Greece)Article
- Repetitive Painting (REPEAT) Irradiation in Stereotactic Radiotherapy Using Helical Tomotherapy.In vivo (Athens, Greece)Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 9 institutions in 2 countries.
Rachit KumarDivision of Radiation Oncology, Banner MD Anderson Cancer Center, Gilbert, AZ (R.K.); Division of Neurosurgery, Department of Surgery, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada (A.N., M.G.F.); Department of Radiation Oncology, Sunnybrook Odette Health Sciences Centre, University of Toronto, Toronto, ON, Canada (A.H., S.M., Y.L., A.S.); Department of Radiation Oncology, University of California San Francisco, San Francisco, CA (L.M.); Department of Radiation Oncology, Johns Hopkins University School of Medicine, Baltimore, MD (K.R.); Department of Radiation Oncology, University Hospitals Seidman Cancer Center, Case Western Reserve University, Cleveland, OH (S.S.L.); Department of Radiation Oncology, University of Southern California, Los Angeles, CA (E.L.C.); Division of Orthopedic Surgery, Sunnybrook Odette Health Sciences Centre, University of Toronto, Toronto, ON, Canada (A.Y.); Division of Orthopedic Surgery, Vancouver General Hospital, University of British Columbia, Vancouver, BC, Canada (C.G.F.).
Anick NaterDivision of Radiation Oncology, Banner MD Anderson Cancer Center, Gilbert, AZ (R.K.); Division of Neurosurgery, Department of Surgery, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada (A.N., M.G.F.); Department of Radiation Oncology, Sunnybrook Odette Health Sciences Centre, University of Toronto, Toronto, ON, Canada (A.H., S.M., Y.L., A.S.); Department of Radiation Oncology, University of California San Francisco, San Francisco, CA (L.M.); Department of Radiation Oncology, Johns Hopkins University School of Medicine, Baltimore, MD (K.R.); Department of Radiation Oncology, University Hospitals Seidman Cancer Center, Case Western Reserve University, Cleveland, OH (S.S.L.); Department of Radiation Oncology, University of Southern California, Los Angeles, CA (E.L.C.); Division of Orthopedic Surgery, Sunnybrook Odette Health Sciences Centre, University of Toronto, Toronto, ON, Canada (A.Y.); Division of Orthopedic Surgery, Vancouver General Hospital, University of British Columbia, Vancouver, BC, Canada (C.G.F.).
Ahmed HashmiDivision of Radiation Oncology, Banner MD Anderson Cancer Center, Gilbert, AZ (R.K.); Division of Neurosurgery, Department of Surgery, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada (A.N., M.G.F.); Department of Radiation Oncology, Sunnybrook Odette Health Sciences Centre, University of Toronto, Toronto, ON, Canada (A.H., S.M., Y.L., A.S.); Department of Radiation Oncology, University of California San Francisco, San Francisco, CA (L.M.); Department of Radiation Oncology, Johns Hopkins University School of Medicine, Baltimore, MD (K.R.); Department of Radiation Oncology, University Hospitals Seidman Cancer Center, Case Western Reserve University, Cleveland, OH (S.S.L.); Department of Radiation Oncology, University of Southern California, Los Angeles, CA (E.L.C.); Division of Orthopedic Surgery, Sunnybrook Odette Health Sciences Centre, University of Toronto, Toronto, ON, Canada (A.Y.); Division of Orthopedic Surgery, Vancouver General Hospital, University of British Columbia, Vancouver, BC, Canada (C.G.F.).
Sten MyrehaugDivision of Radiation Oncology, Banner MD Anderson Cancer Center, Gilbert, AZ (R.K.); Division of Neurosurgery, Department of Surgery, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada (A.N., M.G.F.); Department of Radiation Oncology, Sunnybrook Odette Health Sciences Centre, University of Toronto, Toronto, ON, Canada (A.H., S.M., Y.L., A.S.); Department of Radiation Oncology, University of California San Francisco, San Francisco, CA (L.M.); Department of Radiation Oncology, Johns Hopkins University School of Medicine, Baltimore, MD (K.R.); Department of Radiation Oncology, University Hospitals Seidman Cancer Center, Case Western Reserve University, Cleveland, OH (S.S.L.); Department of Radiation Oncology, University of Southern California, Los Angeles, CA (E.L.C.); Division of Orthopedic Surgery, Sunnybrook Odette Health Sciences Centre, University of Toronto, Toronto, ON, Canada (A.Y.); Division of Orthopedic Surgery, Vancouver General Hospital, University of British Columbia, Vancouver, BC, Canada (C.G.F.).
Young LeeDivision of Radiation Oncology, Banner MD Anderson Cancer Center, Gilbert, AZ (R.K.); Division of Neurosurgery, Department of Surgery, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada (A.N., M.G.F.); Department of Radiation Oncology, Sunnybrook Odette Health Sciences Centre, University of Toronto, Toronto, ON, Canada (A.H., S.M., Y.L., A.S.); Department of Radiation Oncology, University of California San Francisco, San Francisco, CA (L.M.); Department of Radiation Oncology, Johns Hopkins University School of Medicine, Baltimore, MD (K.R.); Department of Radiation Oncology, University Hospitals Seidman Cancer Center, Case Western Reserve University, Cleveland, OH (S.S.L.); Department of Radiation Oncology, University of Southern California, Los Angeles, CA (E.L.C.); Division of Orthopedic Surgery, Sunnybrook Odette Health Sciences Centre, University of Toronto, Toronto, ON, Canada (A.Y.); Division of Orthopedic Surgery, Vancouver General Hospital, University of British Columbia, Vancouver, BC, Canada (C.G.F.).
Lijun MaDivision of Radiation Oncology, Banner MD Anderson Cancer Center, Gilbert, AZ (R.K.); Division of Neurosurgery, Department of Surgery, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada (A.N., M.G.F.); Department of Radiation Oncology, Sunnybrook Odette Health Sciences Centre, University of Toronto, Toronto, ON, Canada (A.H., S.M., Y.L., A.S.); Department of Radiation Oncology, University of California San Francisco, San Francisco, CA (L.M.); Department of Radiation Oncology, Johns Hopkins University School of Medicine, Baltimore, MD (K.R.); Department of Radiation Oncology, University Hospitals Seidman Cancer Center, Case Western Reserve University, Cleveland, OH (S.S.L.); Department of Radiation Oncology, University of Southern California, Los Angeles, CA (E.L.C.); Division of Orthopedic Surgery, Sunnybrook Odette Health Sciences Centre, University of Toronto, Toronto, ON, Canada (A.Y.); Division of Orthopedic Surgery, Vancouver General Hospital, University of British Columbia, Vancouver, BC, Canada (C.G.F.).
Kristin RedmondDivision of Radiation Oncology, Banner MD Anderson Cancer Center, Gilbert, AZ (R.K.); Division of Neurosurgery, Department of Surgery, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada (A.N., M.G.F.); Department of Radiation Oncology, Sunnybrook Odette Health Sciences Centre, University of Toronto, Toronto, ON, Canada (A.H., S.M., Y.L., A.S.); Department of Radiation Oncology, University of California San Francisco, San Francisco, CA (L.M.); Department of Radiation Oncology, Johns Hopkins University School of Medicine, Baltimore, MD (K.R.); Department of Radiation Oncology, University Hospitals Seidman Cancer Center, Case Western Reserve University, Cleveland, OH (S.S.L.); Department of Radiation Oncology, University of Southern California, Los Angeles, CA (E.L.C.); Division of Orthopedic Surgery, Sunnybrook Odette Health Sciences Centre, University of Toronto, Toronto, ON, Canada (A.Y.); Division of Orthopedic Surgery, Vancouver General Hospital, University of British Columbia, Vancouver, BC, Canada (C.G.F.).
Simon S LoDivision of Radiation Oncology, Banner MD Anderson Cancer Center, Gilbert, AZ (R.K.); Division of Neurosurgery, Department of Surgery, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada (A.N., M.G.F.); Department of Radiation Oncology, Sunnybrook Odette Health Sciences Centre, University of Toronto, Toronto, ON, Canada (A.H., S.M., Y.L., A.S.); Department of Radiation Oncology, University of California San Francisco, San Francisco, CA (L.M.); Department of Radiation Oncology, Johns Hopkins University School of Medicine, Baltimore, MD (K.R.); Department of Radiation Oncology, University Hospitals Seidman Cancer Center, Case Western Reserve University, Cleveland, OH (S.S.L.); Department of Radiation Oncology, University of Southern California, Los Angeles, CA (E.L.C.); Division of Orthopedic Surgery, Sunnybrook Odette Health Sciences Centre, University of Toronto, Toronto, ON, Canada (A.Y.); Division of Orthopedic Surgery, Vancouver General Hospital, University of British Columbia, Vancouver, BC, Canada (C.G.F.).
Eric L ChangDivision of Radiation Oncology, Banner MD Anderson Cancer Center, Gilbert, AZ (R.K.); Division of Neurosurgery, Department of Surgery, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada (A.N., M.G.F.); Department of Radiation Oncology, Sunnybrook Odette Health Sciences Centre, University of Toronto, Toronto, ON, Canada (A.H., S.M., Y.L., A.S.); Department of Radiation Oncology, University of California San Francisco, San Francisco, CA (L.M.); Department of Radiation Oncology, Johns Hopkins University School of Medicine, Baltimore, MD (K.R.); Department of Radiation Oncology, University Hospitals Seidman Cancer Center, Case Western Reserve University, Cleveland, OH (S.S.L.); Department of Radiation Oncology, University of Southern California, Los Angeles, CA (E.L.C.); Division of Orthopedic Surgery, Sunnybrook Odette Health Sciences Centre, University of Toronto, Toronto, ON, Canada (A.Y.); Division of Orthopedic Surgery, Vancouver General Hospital, University of British Columbia, Vancouver, BC, Canada (C.G.F.).
Albert YeeDivision of Radiation Oncology, Banner MD Anderson Cancer Center, Gilbert, AZ (R.K.); Division of Neurosurgery, Department of Surgery, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada (A.N., M.G.F.); Department of Radiation Oncology, Sunnybrook Odette Health Sciences Centre, University of Toronto, Toronto, ON, Canada (A.H., S.M., Y.L., A.S.); Department of Radiation Oncology, University of California San Francisco, San Francisco, CA (L.M.); Department of Radiation Oncology, Johns Hopkins University School of Medicine, Baltimore, MD (K.R.); Department of Radiation Oncology, University Hospitals Seidman Cancer Center, Case Western Reserve University, Cleveland, OH (S.S.L.); Department of Radiation Oncology, University of Southern California, Los Angeles, CA (E.L.C.); Division of Orthopedic Surgery, Sunnybrook Odette Health Sciences Centre, University of Toronto, Toronto, ON, Canada (A.Y.); Division of Orthopedic Surgery, Vancouver General Hospital, University of British Columbia, Vancouver, BC, Canada (C.G.F.).
Charles G FisherDivision of Radiation Oncology, Banner MD Anderson Cancer Center, Gilbert, AZ (R.K.); Division of Neurosurgery, Department of Surgery, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada (A.N., M.G.F.); Department of Radiation Oncology, Sunnybrook Odette Health Sciences Centre, University of Toronto, Toronto, ON, Canada (A.H., S.M., Y.L., A.S.); Department of Radiation Oncology, University of California San Francisco, San Francisco, CA (L.M.); Department of Radiation Oncology, Johns Hopkins University School of Medicine, Baltimore, MD (K.R.); Department of Radiation Oncology, University Hospitals Seidman Cancer Center, Case Western Reserve University, Cleveland, OH (S.S.L.); Department of Radiation Oncology, University of Southern California, Los Angeles, CA (E.L.C.); Division of Orthopedic Surgery, Sunnybrook Odette Health Sciences Centre, University of Toronto, Toronto, ON, Canada (A.Y.); Division of Orthopedic Surgery, Vancouver General Hospital, University of British Columbia, Vancouver, BC, Canada (C.G.F.).
Michael G FehlingsDivision of Radiation Oncology, Banner MD Anderson Cancer Center, Gilbert, AZ (R.K.); Division of Neurosurgery, Department of Surgery, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada (A.N., M.G.F.); Department of Radiation Oncology, Sunnybrook Odette Health Sciences Centre, University of Toronto, Toronto, ON, Canada (A.H., S.M., Y.L., A.S.); Department of Radiation Oncology, University of California San Francisco, San Francisco, CA (L.M.); Department of Radiation Oncology, Johns Hopkins University School of Medicine, Baltimore, MD (K.R.); Department of Radiation Oncology, University Hospitals Seidman Cancer Center, Case Western Reserve University, Cleveland, OH (S.S.L.); Department of Radiation Oncology, University of Southern California, Los Angeles, CA (E.L.C.); Division of Orthopedic Surgery, Sunnybrook Odette Health Sciences Centre, University of Toronto, Toronto, ON, Canada (A.Y.); Division of Orthopedic Surgery, Vancouver General Hospital, University of British Columbia, Vancouver, BC, Canada (C.G.F.).
Arjun SahgalDivision of Radiation Oncology, Banner MD Anderson Cancer Center, Gilbert, AZ (R.K.); Division of Neurosurgery, Department of Surgery, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada (A.N., M.G.F.); Department of Radiation Oncology, Sunnybrook Odette Health Sciences Centre, University of Toronto, Toronto, ON, Canada (A.H., S.M., Y.L., A.S.); Department of Radiation Oncology, University of California San Francisco, San Francisco, CA (L.M.); Department of Radiation Oncology, Johns Hopkins University School of Medicine, Baltimore, MD (K.R.); Department of Radiation Oncology, University Hospitals Seidman Cancer Center, Case Western Reserve University, Cleveland, OH (S.S.L.); Department of Radiation Oncology, University of Southern California, Los Angeles, CA (E.L.C.); Division of Orthopedic Surgery, Sunnybrook Odette Health Sciences Centre, University of Toronto, Toronto, ON, Canada (A.Y.); Division of Orthopedic Surgery, Vancouver General Hospital, University of British Columbia, Vancouver, BC, Canada (C.G.F.).
Johns Hopkins University · USUniversity Hospitals Seidman Cancer Center · USUniversity of California, San Francisco · USUniversity of Toronto · CABanner MD Anderson Cancer CenterJohns Hopkins Medicine · USThe University of Texas MD Anderson Cancer Center · USUniversity of British Columbia · CAVancouver General Hospital · CA
Funding
No grant is acknowledged in the PubMed record.
Abstract
Spinal metastases are increasingly becoming a focus of attention with respect to treating with locally "ablative" intent, as opposed to locally "palliative" intent. This is due to increasing survival rates among patients with metastatic disease, early detection as a result of increasing availability of spinal MRI, the recognition of the oligometastatic state as a distinct sub-group of favorable metastatic patients and the advent of stereotactic body radiotherapy (SBRT). Although conventionally fractionated radiation therapy has been utilized for decades, the rates of complete pain relief and local control for complex tumors are sub-optimal. SBRT has the advantage of delivering high total doses in few fractions (typically, 24 Gy in 1 or 2 fractions to 30-45 Gy in 5 fractions) that can be considered "ablative". With mature clinical experience emerging among early adopters, we are realizing beyond efficacy the limitations of spine SBRT. In particular, toxicities such as vertebral compression fracture, and epidural disease progression as the most common pattern of local tumor progression. As a result, the multidisciplinary evaluation of cases prior to SBRT is emphasized with the intent to identify patients who could benefit from surgical stabilization or down-staging of epidural disease. The purpose of this review is to provide an overview of the current literature with respect to outcomes, technical details for safe delivery, patient selection criteria, common and uncommon side effects of therapy, and the increasing use of minimally invasive surgical techniques that can improve both safety and local control.
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metastasisSABRSBRTspinestereotactic
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