ArticleJournal of laboratory physicians
Predictive values of neutrophil-lymphocyte ratio as an early indicator for severe acute pancreatitis in the emergency department patients.
Article in Journal of laboratory physicians. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 3 of them syntheses that pooled it.
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Who cites it
17 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Neutrophil-to-lymphocyte ratio for primary risk stratification in acute pancreatitis: a systematic review and meta-analysis.Frontiers in medicine · 2025Pooled it
- Chronic liver disease is an important risk factor for worse outcomes in acute pancreatitis: a systematic review and meta-analysis.Scientific reports · 2024Pooled it
- Neutrophil to lymphocyte ratio and albumin bilirubin grade in hepatocellular carcinoma: A systematic review.World journal of gastroenterology · 2020Pooled it
- Construction and validation of machine learning models for sepsis prediction in patients with acute pancreatitis.BMC surgery · 2023Trial
- Article
- Article
- Analysis of the association between the neutrophil-to-lymphocyte ratio (NLR) and liver injury complicating acute pancreatitis: a retrospective study.Frontiers in medicine · 2026Article
- Evaluation of Acute Pancreatitis Severity and Prognosis Using the Aggregate Systemic Inflammation Index (AISI) as a New Marker: A Comparison with Other Inflammatory Indices.Journal of clinical medicine · 2025Article
- Review
- The value of NLR, PLR, PCT, and D-D levels in assessing the severity of hyperlipidemic acute pancreatitis.Frontiers in medicine · 2025Article
- Article
- Development and internal validation of a practical model to predict 30 days mortality of severe acute pancreatitis patients.Annals of medicine · 2023Article
- High Triglyceride-Glucose Index Is Associated with Poor Prognosis in Patients with Acute Pancreatitis.Digestive diseases and sciences · 2023Article
- Hypertriglyceridaemia-Induced Acute Pancreatitis: A Different Disease Phenotype.Diagnostics (Basel, Switzerland) · 2022Article
- Monitoring Approach of Fatality Risk Factors for Patients with Severe Acute Pancreatitis Admitted to the Intensive Care Unit. A Retrospective, Monocentric Study.Diagnostics (Basel, Switzerland) · 2021Article
- Evaluation of Prognostic Factors of Severity in Acute Biliary Pancreatitis.International journal of molecular sciences · 2020Observational
- New markers in predicting the severity of acute pancreatitis in the emergency department: Immature granulocyte count and percentage.Journal of postgraduate medicineArticle
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
contextAcute pancreatitis is an acute inflammatory disease presenting with a wide range of severity.
aimsWe investigated the predictive values of the neutrophil-lymphocyte ratio (NLR) as an indicator for severe acute pancreatitis in the emergency department patients. SETTINGS AND
designThis retrospective study was conducted on patients with acute pancreatitis who were diagnosed in the emergency department, from January 2008 to December 2017. SUBJECTS AND
methodsPatients were classified into either mild-to-moderate severe group or severe group according to the Revised Atlanta Classification for Acute Pancreatitis. Clinical features and laboratory blood test parameters were considered as independent variables. STATISTICAL ANALYSIS USED: Independent variables were analyzed using the Chi-square test and Mann-Whitney U-test to determine statistically significant differences between the two groups. Logistic regression analysis and receiver operating characteristic analysis were performed to evaluate the predictive values of significantly different variables.
resultsOf the 672 patients, 52 (7.7%) were classified into the severe group. Tachycardia, fever, prevalence of liver cirrhosis and chronic alcoholism, white blood cell count, NLR, C-reactive protein (CRP), blood urea nitrogen (BUN), creatinine, aspartate transaminase, and total bilirubin were significantly higher in the severe group. Among them, NLR (adjusted odds ratio [aOR]: 1.13; 95% confidence interval [CI]: 1.081-1.181), CRP (aOR: 1.011; 95% CI: 1.004-1.017), BUN (aOR: 1.036; 95% CI: 1.004-1.069), and creatinine (aOR: 1.703; 95% CI: 1.008-2.877) were significant in the logistic regression analysis. NLR showed relatively high sensitivity (82.7%) and specificity (70%) and showed the highest area under the curve (0.821).
conclusionsThe increase in NLR was associated with severe acute pancreatitis. NLR is expected to be useful as a prognostic factor in patients with acute pancreatitis who are visiting the emergency department.
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