Evidence map›Paper›PMID 31579108›Full record

ReviewTherapeutic advances in medical oncology2019

The mechanisms of acute interstitial nephritis in the era of immune checkpoint inhibitors in melanoma.

Tucci Marco, Passarelli Anna, Todisco Annalisa, Mannavola Francesco, Stucci Luigia Stefania, D'Oronzo Stella, Rossini Michele, Taurisano Marco, Gesualdo Loreto, Silvestris Franco

Erratum issuedOpen access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Therapeutic advances in medical oncology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 23 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 2 pooled it
1.6field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 31 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Review
  10. Review
  11. Article
  12. Review
  13. Review
  14. Acute Kidney Injury Induced by Immune Checkpoint Inhibitors.Kidney diseases (Basel, Switzerland) · 2022
    Review
  15. Observational
  16. Review
  17. Review
  18. Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Tucci MarcoDIMO, Department of Biomedical Sciences and Clinical Oncology, University of Bari 'Aldo Moro', Section of Internal Medicine and Oncology, P.za Giulio Cesare, 11 - 70124 BARI, Italy.ORCID https://orcid.org/0000-0003-4008-4897
Passarelli AnnaDIMO, Department of Biomedical Sciences and Clinical Oncology, University of Bari, 'Aldo Moro' Italy.
Todisco AnnalisaDIMO, Department of Biomedical Sciences and Clinical Oncology, University of Bari, 'Aldo Moro' Italy.
Mannavola FrancescoDIMO, Department of Biomedical Sciences and Clinical Oncology, University of Bari, 'Aldo Moro' Italy.
Stucci Luigia StefaniaDIMO, Department of Biomedical Sciences and Clinical Oncology, University of Bari, 'Aldo Moro' Italy.
D'Oronzo StellaDIMO, Department of Biomedical Sciences and Clinical Oncology, University of Bari, 'Aldo Moro' Italy.
Rossini MicheleDETO, Department of Emergency and Organ Transplantation, University of Bari, 'Aldo Moro' Italy.
Taurisano MarcoDETO, Department of Emergency and Organ Transplantation, University of Bari, 'Aldo Moro' Italy.
Gesualdo LoretoDETO, Department of Emergency and Organ Transplantation, University of Bari, 'Aldo Moro' Italy.
Silvestris FrancoDIMO, Department of Biomedical Sciences and Clinical Oncology, University of Bari, 'Aldo Moro' Italy.
University of Bari Aldo Moro · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Treatment with immune checkpoint inhibitors (ICIs) has improved the prognosis of patients with a number of types of cancer, but the frequent development of immune-related adverse effects (irAEs) can worsen the outcome. The most common irAEs involve the gastrointestinal, cutaneous, and endocrine systems, but nephrotoxicity, resulting from damage to the tubule-interstitial compartment, may occur in some patients. The early phases of acute interstitial nephritis (AIN) are characterized by systemic symptoms that indicate a poor clinical state as well as a mild deterioration of renal function. Tubular injury is due to a direct effect mediated by cytotoxic CD8

Indexed as

acute interstitial nephritisimmunotherapymelanomanephrotoxicity

Identifiers

PMID31579108
PMCPMC6759704
OpenAlexW2976964237

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.