ArticleAnnals of clinical and translational neurology2019
Naming fMRI predicts the effect of temporal lobe resection on language decline.
Article in Annals of clinical and translational neurology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
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The trial behind it
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Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 43 citations in OpenAlex.
- Pooled it
- Roles of fMRI and Wada tests in the presurgical evaluation of language functions in temporal lobe epilepsy.Frontiers in neurology · 2022Pooled it
- A systematic review of the impact of stimulus presentation modality on fMRI studies for presurgical mapping.Neuroimage. Reports · 2026Review
- Determining hemispheric language dominance from MEG beta-power modulations: Concordance with fMRI.NeuroImage · 2026Article
- A Rapid fMRI Paradigm for Localisation of the Language Network.The European journal of neuroscience · 2026Article
- A left-lateralized dorsolateral prefrontal network for naming.Cell reports · 2025Article
- Long-term neuroplasticity in language networks after anterior temporal lobe resection.Epilepsia · 2025Article
- Dissociation of reading and naming in ventral occipitotemporal cortex.Brain : a journal of neurology · 2024Article
- Naming fMRI-guided white matter language tract volumes influence naming decline after temporal lobe resection.Journal of neurology · 2024Article
- Age of epilepsy onset as modulating factor for naming deficit after epilepsy surgery: a voxel-based lesion-symptom mapping study.Scientific reports · 2023Article
- Contribution of White Matter Fiber Bundle Damage to Language Change After Surgery for Temporal Lobe Epilepsy.Neurology · 2023Article
- The impact of temporal lobe epilepsy surgery on picture naming and its relationship to network metric change.NeuroImage. Clinical · 2023Article
- Review
- The importance of basal-temporal white matter to pre- and post-surgical naming ability in temporal lobe epilepsy.NeuroImage. Clinical · 2022Article
- Resection of dominant fusiform gyrus is associated with decline of naming function when temporal lobe epilepsy manifests after the age of five: A voxel-based lesion-symptom mapping study.NeuroImage. Clinical · 2022Article
- Decoupling of functional and structural language networks in temporal lobe epilepsy.Epilepsia · 2021Article
- Mapping of Language-and-Memory Networks in Patients With Temporal Lobe Epilepsy by Using the GE2REC Protocol.Frontiers in human neuroscience · 2021Article
- Impaired naming performance in temporal lobe epilepsy: language fMRI responses are modulated by disease characteristics.Journal of neurology · 2021Article
- Combining Gamma With Alpha and Beta Power Modulation for Enhanced Cortical Mapping in Patients With Focal Epilepsy.Frontiers in human neuroscience · 2020Article
- Language Dominance in Patients With Malformations of Cortical Development and Epilepsy.Frontiers in neurology · 2019Article
Corrections and comments
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Authors and funding
11 authors at 1 institution in 2 countries.
Funding
Abstract
objectiveTo develop language functional MRI (fMRI) methods that accurately predict postsurgical naming decline in temporal lobe epilepsy (TLE).
methodsForty-six patients with TLE (25 left) and 19 controls underwent two overt fMRI paradigms (auditory naming and picture naming, both with active baseline conditions) and one covert task (verbal fluency). Clinical naming performance was assessed preoperatively and 4 months following anterior temporal lobe resection. Preoperative fMRI activations were correlated with postoperative naming decline. Individual laterality indices (LI) were calculated for temporal (auditory and picture naming) and frontal regions (verbal fluency) and were considered as predictors of naming decline in multiple regression models, along with other clinical variables (age at onset of seizures, preoperative naming scores, hippocampal volume, age).
resultsIn left TLE patients, activation of the left posterior inferior temporal gyrus during auditory naming and activation of left fusiform gyrus during picture naming were related to greater postoperative naming decline. Activation LI were the best individual predictors of naming decline in a multivariate regression model. For picture naming, an LI of higher than 0.34 gave 100% sensitivity and 92% specificity (positive predictive value (PPV) 91.6%). For auditory naming, a temporal lobe LI higher than 0.18 identified all patients with a clinically significant naming decline with 100% sensitivity and 58% specificity (PPV: 58.3%). No effect was seen for verbal fluency.
interpretationAuditory and picture naming fMRI are clinically applicable to predict postoperative naming decline after left temporal lobe resection in individual patients, with picture naming being more specific.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.