Observational studyJournal of neuro-oncology2019
WHO grade of intracranial meningiomas differs with respect to patient's age, location, tumor size and peritumoral edema.
Observational study in Journal of neuro-oncology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed.
- Preoperative prediction of meningioma grade based on synthetic MRI quantitative T1 and T2 mapping.Japanese journal of radiology · 2026Article
- FOXC1 as a molecular predictor of postoperative peritumoral edema resolution in meningiomas.Journal of neuro-oncology · 2026Article
- A Novel Nomogram for Predicting Meningioma Grade Based on Radiomics Features and Clinical Characteristics.Current medical science · 2026Article
- A unified FLAIR hyperintensity segmentation model for various CNS tumor types and acquisition time points.Scientific reports · 2026Article
- FOXC1 expression and radiological predictors of peritumoral brain edema in meningiomas.Journal of neuro-oncology · 2026Article
- Diagnostic Value of Routine MRI Parameters in Identifying High-Grade Intracranial Meningiomas.Neuroradiology · 2026Article
- Risk factors associated with higher WHO grade in meningiomas: a multicentric study of 552 skull base meningiomas.Scientific reports · 2025Article
- Radiographic predictors of peritumoral brain edema in intracranial meningiomas: a review of current controversies and illustrative cases.Chinese neurosurgical journal · 2024Review
- Multiparameter MRI-based radiomics nomogram for preoperative prediction of brain invasion in atypical meningioma:a multicentre study.BMC medical imaging · 2024Article
- A comprehensive correlation of the KI-67 proliferation index to patient´s, imaging and tumor features and its value in predicting long-term course of patients with newly diagnosed intracranial meningiomas.Neurosurgical review · 2024Article
- Multi-parametric MRI-based machine learning model for prediction of WHO grading in patients with meningiomas.European radiology · 2024Article
- Meningioma recurrence: Time for an online prediction tool?Surgical neurology international · 2024Review
- Lateral ventricle meningiomas in children: clinicopathological and neuroradiological features.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2023Article
- Comparison of Short-Term Surgery Outcomes and Clinical Characteristics Between Elderly and Non-Elderly Patients with Middle Third Parasagittal and Parafalcine Meningiomas.Neuropsychiatric disease and treatment · 2023Article
- Clinical and pathological impact of an optimal assessment of brain invasion for grade 2 meningioma diagnosis: lessons from a series of 291 cases.Neurosurgical review · 2022Article
- Consensus core clinical data elements for meningiomas (v2021.1).Neuro-oncology · 2022Article
- Are there predilection sites for intracranial meningioma? A population-based atlas.Neurosurgical review · 2022Article
- Differentiation between various types and subtypes of intracranial meningiomas with advanced MRI.SA journal of radiology · 2022Article
- Article
- Retrospective Analysis and Comparison of 48 Intracranial Meningioma Cases As Two Groups According to Their Size.Cureus · 2021Article
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Abstract
purposeTo analyse whether the WHO grade of intracranial meningiomas differs itself depending on patients and meningioma characteristics at diagnosis.
methodsSingle center retrospective study of a series of consecutive patients with primary intracranial meningiomas who underwent surgery between January 2007 and March 2014. Patients (age, sex, outcome) and meningioma characteristics (histological diagnosis, tumor location, WHO grading, size, extend of peritumoral edema and tumor recurrence rate) were analysed.
resultsOf 240 included patients, 184 (76.7%) were female and 56 (23.3%) were male. 17 patients (7.1%) were in age group 20-40 years, 112 (46.7%) in group 41-60 years and 111 (46.3%) were in age group > 60 years. 189 patients (78.8%) were diagnosed with WHO grade I, 49 (20.4%) WHO grade II and 2 (0.8%) had a WHO grade III meningioma. WHO grade II meningiomas were significantly more frequent in the age group 20-40 years compared to age group 41-60 years (chi-square p < 0.05). Convexity meningiomas were significantly more frequent classified as WHO grade II meningiomas compared to all other locations (chi-square, p < 0.01). Mean calculated tumor volume and the tumor volume determined by volumetric measurement was significantly larger in grade II meningioma patients compared to grade I (46.3 ± 40.5 cc grade II versus 21.8 ± 27.8 cc grade I and 45.3 ± 38.2 cc versus 23.1 ± 30.0 cc respectively; t test < 0.01). Extend of the peritumoral edema was significantly larger in patients with grade II meningiomas (Wilcoxon test, p < 0.05). Short term outcome did not differ between different age groups nor was it associated with tumor size. During a mean follow up of 49 months (min 3, max 144 months) recurrence rate was significantly higher in WHO grade II (4 out of 49 [8.2]%) compared to WHO grade I patients (3 out if 186, [1.6%]; Chi-square, p < 0.05).
conclusionIn this series atypical meningioma was associated with younger age, location on the convexity, larger tumor size and more peritumoral edema.
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