Evidence map›Paper›PMID 31578670›Full record

ArticleActa parasitologica2020

Comparison Between Immuno-Clinicopathological Features of Experimental and Human Visceral Leishmaniasis by Leishmania donovani.

Sheetal Saini, Anuradha Dube, Amogh Anant Sahasrabuddhe, Chandreshwar Prasad Thakur, Sumit Joshi, Keerti Rawat, Ambak Kumar Rai

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in Acta parasitologica, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Linoleic Acid Inhibits the Release ofFrontiers in cellular and infection microbiology · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Sheetal SainiDepartment of Biotechnology, Motilal Nehru National Institute of Technology (MNNIT), Prayagraj, UP, 211004, India.
Anuradha DubeDivision of Parasitology, CSIR-Central Drug Research Institute (CSIR-CDRI), Lucknow, 226031, India.
Amogh Anant SahasrabuddheMolecular and Structural Biology Division, CSIR-Central Drug Research Institute (CSIR-CDRI), Lucknow, 226031, India.
Chandreshwar Prasad ThakurBalaji Utthan Sansthan, Patna, 800001, India.
Sumit JoshiDivision of Parasitology, CSIR-Central Drug Research Institute (CSIR-CDRI), Lucknow, 226031, India.
Keerti RawatMolecular and Structural Biology Division, CSIR-Central Drug Research Institute (CSIR-CDRI), Lucknow, 226031, India.
Ambak Kumar RaiDepartment of Biotechnology, Motilal Nehru National Institute of Technology (MNNIT), Prayagraj, UP, 211004, India. ambakrai@mnnit.ac.in.

Funding

Council of Scientific and Industrial Research, India 09/1032(0006)/2015-EMR-1Department of Biotechnology , Ministry of Science and Technology BT/PR14154/MED/29/965/2015Science and Engineering Research Board SB/YS/LS-234/2013
6 · The paper itself

Abstract

backgroundCurrent understanding of visceral leishmaniasis (VL) depends upon the experimental model. Different species of mouse and hamster have been used as model for VL. It is already evident that the mouse model of VL is not a true reflection of the pathology of human visceral leishmaniasis (HuVL). On the other hand, hamster is reported to be a better model of VL to study the progressive as well as chronic pathology of the disease.

objectiveTo compare immuno-clinicopathological features of experimental VL (ExVL) and HuVL by Leishmania donovani.

methodsHamsters were infected (15 and 60 days) and their immunological, clinical and biochemical parameters were compared with the cases of HuVL.

resultsSplenomegaly and hepatomegaly were observed in infected hamster post-infection, which are hallmarks of symptomatic HuVL cases. Clinical, biochemical and pathological manifestations of infected hamsters were consistent with that of HuVL cases, except parameters such as body weight, uric acid, alkaline phosphatase and random glucose. The absence of clear dichotomy between pro- and anti-inflammatory cytokines was also observed after infection at different sites of infection.

conclusionOur results suggest that the golden hamster (Mesocricetus auratus), infected via the intracardiac route, constitutes a very good model for the study of experimental Leishmania donovani infections. However, certain differences in clinical presentations of infected hamsters (via intracardiac route) with HuVL suggest further optimization of this animal model like route of infection such as intradermal, which is more close to natural infection.

Indexed as

Disease Models, AnimalAdolescentAdultAnimalsCricetinaeCytokinesDNA PrimersDNA, ProtozoanFemaleHepatomegalyHumansLeishmania donovaniLeishmaniasis, VisceralMaleMesocricetusSplenomegalyCytokinesDNA PrimersDNA, ProtozoanExperimental modelHuman visceral leishmaniasisImmuno-clinicopathological featuresLeishmania donovaniMesocricetus auratusVisceral leishmaniasis

Identifiers

PMID31578670

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