ArticleClinical neuroradiology2020
Functional Connectivity Alterations in Neuromyelitis Optica Spectrum Disorder : Correlation with Disease Duration and Cognitive Impairment.
Article in Clinical neuroradiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Functional and effective connectivity alterations relate to cognitive performance in aquaporin-4 antibody-positive neuromyelitis optica spectrum disorder.Brain communications · 2026Article
- Changes in brain functional connectivity and clinical correlations in neuromyelitis optica spectrum disorder: a longitudinal resting-state fMRI study.European journal of medical research · 2025Article
- Differentiation between multiple sclerosis and neuromyelitis optic spectrum disorders with multilevel fMRI features: A machine learning analysis.Scientific reports · 2025Article
- Cerebellar microstructural and functional connectivity changes in patients with neuromyelitis optica spectrum disorders and their correlation with cognitive function: a female-dominated multimodal MRI study.Frontiers in neurology · 2025Article
- Spinal cord and brain atrophy patterns in neuromyelitis optica spectrum disorder and multiple sclerosis.Journal of neurology · 2024Article
- Macrophage Migration Inhibitory Factor as a Potential Plasma Biomarker of Cognitive Impairment in Cerebral Small Vessel Disease.ACS omega · 2024Article
- Temporal and topological properties of dynamic networks reflect disability in patients with neuromyelitis optica spectrum disorders.Scientific reports · 2024Article
- Abnormal brain spontaneous neural activity in neuromyelitis optica spectrum disorder with neuropathic pain.Frontiers in neurology · 2024Article
- Specific static and dynamic functional network connectivity changes in thyroid-associated ophthalmopathy and it predictive values using machine learning.Frontiers in neuroscience · 2024Article
- In patients with mild disability NMOSD: is the alteration in the cortical morphological or functional network topological properties more significant.Frontiers in immunology · 2024Article
- Correlation between cerebral cortex changes and clinical features in patients with neuromyelitis optica spectrum disorder with normal-appearing brain tissue: a case-control study.Neural regeneration research · 2023Article
- Cerebellar connectome alterations and associated genetic signatures in multiple sclerosis and neuromyelitis optica spectrum disorder.Journal of translational medicine · 2023Article
- Paths to hippocampal damage in neuromyelitis optica spectrum disorders.Neuropathology and applied neurobiology · 2023Article
- The Characteristics of Cognitive Proficiency in Patients with Acute Neuromyelitis Optica Spectrum Disease and its Correlation with Serum Aquaporin-4 Antibody Titer.Brain sciences · 2023Article
- Time-varying connectivity of the precuneus and its association with cognition and depressive symptoms in neuromyelitis optica: A pilot MRI study.Multiple sclerosis (Houndmills, Basingstoke, England) · 2022Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
purposeThe aim of this study was to investigate resting state functional connectivity alterations within the main brain networks in neuromyelitis optica spectrum disorder (NMOSD) and their associations with disease duration, disability and cognitive dysfunction progression.
methodsResting state functional magnetic resonance imaging (rs-fMRI), clinical and neuropsychological evaluations were obtained from 41 NMOSD patients and 41 healthy controls. Seed-voxel functional connectivity was analyzed in seven major hubs, including the default mode network, dorsal attention network, visual network, sensorimotor network, cerebellar network, thalamic network and reward-emotion network. Abnormalities of functional connectivity and correlations with disease duration, scores of the expanded disability status scale (EDSS), mini-mental state examination (MMSE) and Montreal cognitive assessment (MoCA) were further explored.
resultsCompared with healthy controls, NMOSD patients showed increased functional connectivity in the default mode network, dorsal attention network and thalamic network, while decreased in the visual network and cerebellum networks. At the regional level, increased functional connectivity involved the right superior temporal gyrus, left fusiform gyrus, left inferior parietal lobule, bilateral middle frontal gyrus and right precuneus, whereas functional connectivity was decreased in the right parahippocampal gyrus and left precuneus. Functional connectivity reduction in the right parahippocampal gyrus positively correlated with disease duration (r = 0.488, p = 0.001) and negatively correlated with MoCA scores (r = -0.330, p = 0.035).
conclusionThe study demonstrated functional alterations in the rs-fMRI of NMOSD, which provide a novel insight into the large-scale selective functional reorganization and could be useful to reveal the characteristics of the physiological mechanism.
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