Evidence map›Paper›PMID 31578522›Full record

ArticleNature2019

The fungal mycobiome promotes pancreatic oncogenesis via activation of MBL.

Berk Aykut, Smruti Pushalkar, Ruonan Chen, Qianhao Li, Raquel Abengozar, Jacqueline I Kim, Sorin A Shadaloey, Dongling Wu, Pamela Preiss, Narendra Verma and 13 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 571 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
571citing papers in PubMed, 5 pooled it
33.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

571 citing papers in PubMed, 5 syntheses or guidelines pooled it, 845 citations in OpenAlex.

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511 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

23 authors at 2 institutions in 1 country.

Berk Aykut *S. Arthur Localio Laboratory, Department of Surgery, New York University School of Medicine, New York, NY, USA.
Smruti Pushalkar *Department of Basic Science and Craniofacial Biology, New York University College of Dentistry, New York, NY, USA.
Ruonan ChenS. Arthur Localio Laboratory, Department of Surgery, New York University School of Medicine, New York, NY, USA.
Qianhao LiDepartment of Basic Science and Craniofacial Biology, New York University College of Dentistry, New York, NY, USA.
Raquel AbengozarS. Arthur Localio Laboratory, Department of Surgery, New York University School of Medicine, New York, NY, USA.
Jacqueline I KimS. Arthur Localio Laboratory, Department of Surgery, New York University School of Medicine, New York, NY, USA.
Sorin A ShadaloeyS. Arthur Localio Laboratory, Department of Surgery, New York University School of Medicine, New York, NY, USA.
Dongling WuS. Arthur Localio Laboratory, Department of Surgery, New York University School of Medicine, New York, NY, USA.
Pamela PreissS. Arthur Localio Laboratory, Department of Surgery, New York University School of Medicine, New York, NY, USA.
Narendra VermaDepartment of Medicine, New York University School of Medicine, New York, NY, USA.
Yuqi GuoDepartment of Basic Science and Craniofacial Biology, New York University College of Dentistry, New York, NY, USA.
Anjana SaxenaBiology Department, Brooklyn College, CUNY, New York, NY, USA.
Mridula VardhanDepartment of Basic Science and Craniofacial Biology, New York University College of Dentistry, New York, NY, USA.
Brian DiskinS. Arthur Localio Laboratory, Department of Surgery, New York University School of Medicine, New York, NY, USA.
Wei WangS. Arthur Localio Laboratory, Department of Surgery, New York University School of Medicine, New York, NY, USA.
Joshua LeinwandS. Arthur Localio Laboratory, Department of Surgery, New York University School of Medicine, New York, NY, USA.
Emma KurzS. Arthur Localio Laboratory, Department of Surgery, New York University School of Medicine, New York, NY, USA.
Juan A Kochen RossiS. Arthur Localio Laboratory, Department of Surgery, New York University School of Medicine, New York, NY, USA.
Mautin HundeyinS. Arthur Localio Laboratory, Department of Surgery, New York University School of Medicine, New York, NY, USA.
Constantinos ZambrinisS. Arthur Localio Laboratory, Department of Surgery, New York University School of Medicine, New York, NY, USA.
Xin LiDepartment of Basic Science and Craniofacial Biology, New York University College of Dentistry, New York, NY, USA.
Deepak SaxenaS. Arthur Localio Laboratory, Department of Surgery, New York University School of Medicine, New York, NY, USA. ds100@nyu.edu.
George MillerS. Arthur Localio Laboratory, Department of Surgery, New York University School of Medicine, New York, NY, USA. george.miller@nyumc.org.
New York University · USThe Graduate Center, CUNY · US

Funding

Project-005UL1TR001445 · NCATS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI BREDELLA, MIRIAM ANTOINETTE, HOCHMAN, JUDITH S · 2015 to 2025
$103.5M
Vaccine FacilityP30CA016087 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ANIRBAN MAITRA · 1985 to 2026
$83.1M
Research Training for Physician-Scientists in Gastrointestinal OncologyT32CA193111 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI BAR-SAGI, DAFNA, WOLFGANG, CHRISTOPHER L. · 2015 to 2024
$2.7M
Targeting Succinate Signaling Impedes Periodontitis ProgressionR01DE027074 · NIDCR · NEW YORK UNIVERSITY · PI GRAVES, DANA T, LI, XIN · 2018 to 2022
$2.6M
Dectin-1 signaling drives pancreatic oncogenesis by inducing macrophage-mediated adaptive immune suppressionR01CA215471 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI BAR-SAGI, DAFNA, WONG, KWOK KIN · 2018 to 2022
$2.3M
Toll-like Receptor Regulation of Pancreatic TumorigenesisR01CA168611 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI COHEN, DEIRDRE, MILLER, GEORGE · 2013 to 2019
$2.1M
Regulation of Pancreatic Oncogenesis by the Gut MicrobiomeR01CA206105 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI SAXENA, DEEPAK, SIMEONE, DIANE M · 2017 to 2021
$1.9M
Modulation of oral microenvironment by E-cigarette aerosol mixturesR01DE025992 · NIDCR · NEW YORK UNIVERSITY · PI LI, XIN, SAXENA, DEEPAK · 2016 to 2019
$1.6M
Dectin-1 Regulates Chronic Liver Fibro-inflammatory DiseaseR01DK106025 · NIDDK · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI MILLER, GEORGE · 2016 to 2018
$1.3M
NCATS NIH HHS UL1 TR001445NCI NIH HHS P30 CA016087NCI NIH HHS R01 CA168611NCI NIH HHS R01 CA206105NCI NIH HHS R01 CA215471NCI NIH HHS T32 CA193111NIDCR NIH HHS R01 DE025992NIDCR NIH HHS R01 DE027074NIDDK NIH HHS R01 DK106025
6 · The paper itself

Abstract

Bacterial dysbiosis accompanies carcinogenesis in malignancies such as colon and liver cancer, and has recently been implicated in the pathogenesis of pancreatic ductal adenocarcinoma (PDA)

Indexed as

CarcinogenesisAdenocarcinomaAnimalsCarcinoma, Pancreatic DuctalCase-Control StudiesComplement ActivationComplement C3Disease ProgressionFemaleGastrointestinal MicrobiomeHumansMaleMannose-Binding LectinMiceMice, Inbred C57BLMycobiomeComplement C3Mannose-Binding Lectin

Identifiers

PMID31578522
PMCPMC6858566
OpenAlexW2979146632

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.